1003-28-7

Basic information

• Product Name: 2-Ethylpyrrolidine
• Synonyms: 2-ethylpyrrolidine(SALTDATA: FREE);2-Ethylpyrrolidine hydrochloride;alpha-Ethylpyrrolidine;Pyrrolidine, 2-ethyl-
• CAS NO: 1003-28-7
• Molecular Formula: C₆H₁₃N
• Molecular Weight: 99.17
• Product Categories: pharmacetical
• Mol File: 1003-28-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 119-123℃
• Boiling Point: 122.4℃ (744 Torr)
• Flash Point: 15.5°C
• Appearance: /
• Density: 0.81g/cm³
• Vapor Pressure: 14.1mmHg at 25°C
• Refractive Index: 1.4442 (589.3 nm 15℃)
• PKA: 10.93±0.10(Predicted)
• CAS DataBase Reference: 2-Ethylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethylpyrrolidine(1003-28-7)
• EPA Substance Registry System: 2-Ethylpyrrolidine(1003-28-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1003-28-7(Hazardous Substances Data)

Usage

Description

2-Ethylpyrrolidine is an organic compound with the molecular formula C6H13N. It is a colorless liquid with a characteristic amine-like odor. It is used as a building block in the synthesis of various pharmaceuticals and chemical compounds.

Uses

Used in Pharmaceutical Industry:
2-Ethylpyrrolidine is used as a reagent for the synthesis of C-4” position substituted macrolide derivatives. These derivatives serve as antibacterial agents, specifically targeting erythromycin-resistant bacteria. The compound plays a crucial role in developing new drugs to combat antibiotic resistance.
Used in Chemical Synthesis:
2-Ethylpyrrolidine is also utilized as an intermediate in the synthesis of various chemical compounds. Its unique structure allows for the creation of a wide range of products, making it a versatile component in the chemical industry.

InChI:InChI=1/C6H13N/c1-2-6-4-3-5-7-6/h6-7H,2-5H2,1H3

Upstream product

• 1192-29-6 2-ethyl-1-pyrroline 
• 1551-06-0 2-ethyl-1H-pyrrole 
• 6055-52-3 hexane-1,6-diamine dihydrochloride 
• 55108-01-5 1-aminohex-trans-4-ene 
• 7647-01-0 hydrogenchloride 
• 124920-12-3 2-ethyl-1-(toluene-4-sulfonyl)-pyrrolidine 
• 109300-48-3 4-nitrohexanal 
• 64-17-5 ethanol 
• 123-75-1 pyrrolidine 
• 74-85-1 ethene 
• 51323-68-3 N-methanesulfonylhexan-1-amine 
• 111-26-2 hexan-1-amine 
• 371255-26-4 trans-4-azido-hex-2-ene 
• 25143-95-7 (E)-hex-4-en-1-yl 4-methylbenzenesulfonate 

Downstream Products

• 26158-82-7 1-Methyl-2-ethyl-pyrrolidin 
• 124920-12-3 2-ethyl-1-(toluene-4-sulfonyl)-pyrrolidine 
• 1431772-80-3 N-(6-(2-ethylpyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride 
• 1024683-76-8 2-ethylpyrrolidine-1-carbonitrile 

Relevant articles and documents

PALLADIUM-PROMOTED CYCLIZATION REACTIONS OF AMINOALKENES

The trifluoromethanesulphonate salts of the aminoalkenes CH2=CH(CH2)3NH2, its 2-methyl, 2,2-dimethyl and N-iso-propyl-derivatives, and CH2=CH(CH2)4NH2 cyclize in the presence of and a nitrogen base to produce the corresponding C- or N-substituted 2-methylpyrrolidines and 2-methylpiperidine, E-CH3CH=CH(CH2)3NH2 produces 2-ethylpyrrolidine and a small amount of 2-methylpiperidine.The regio-selectivity of these reactions differs from that observed for the cyclization of the same substrates promoted by 2-: (1) the palladium reaction with 2-methylpent-4-enylamine produces ca. a 4 : 6 ratio of cis- and trans-2,4-dimethylpyrrolidine while with platinum the converse is true; (2) there is a more marked tendency for attack of the amine at the more substituted alkene carbon atom in the palladium than in the platinum reactions.

Organolanthanide-catalyzed intramolecular hydroamination/ cyclization of amines tethered to 1,2-disubstituted alkenes

(equation presented) This contribution reports the organolanthanide-catalyzed intramolecular hydroamination/cyclization of amines tethered to 1,2-disubstituted alkenes to afford the corresponding mono-and disubstituted pyrrolidines and piperidines by usin

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AMMONIUM SALT, ELECTROLYTE FOR LITHIUM SECONDARY BATTERY, AND LITHIUM SECONDARY BATTERY USING THEM

PROBLEM TO BE SOLVED: To provide: ammonium salt with low viscosity; an electrolyte for a lithium secondary battery; and the lithium secondary battery. SOLUTION: This invention relates to an ammonium salt expressed by the following chemical formula (1). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

GLYT1 TRANSPORTER INHIBITORS

The invention provides a compound of formula (I): or a salt, solvate or a physiologically functional derivative thereof, wherein R1 to R10 are as defined in the specification and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.