10038-81-0

Basic information

• Product Name: methyl 2-[(phenylsulfonyl)amino]benzoate
• Synonyms: benzoic acid, 2-[(phenylsulfonyl)amino]-, methyl ester
• CAS NO: 10038-81-0
• Molecular Formula: C₁₄H₁₃NO₄S
• Molecular Weight: 291.3223
• Mol File: 10038-81-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 447.9°C at 760 mmHg
• Flash Point: 224.7°C
• Density: 1.345g/cm³
• Vapor Pressure: 3.24E-08mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: methyl 2-[(phenylsulfonyl)amino]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[(phenylsulfonyl)amino]benzoate(10038-81-0)
• EPA Substance Registry System: methyl 2-[(phenylsulfonyl)amino]benzoate(10038-81-0)

Safety Data

• Hazardous Substances Data: 10038-81-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-[(phenylsulfonyl)amino]benzoate is a chemical compound with the molecular formula C15H13NO4S. It is an organic compound that contains a benzene ring with a sulfonyl group and an amino group attached to it. methyl 2-[(phenylsulfonyl)amino]benzoate is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in organic chemistry, serving as a starting material for the preparation of other more complex compounds. Methyl 2-[(phenylsulfonyl)amino]benzoate is a white or off-white crystalline powder with a molecular weight of 307.33 g/mol and a melting point of around 168-172°C. It is important to handle this compound with care, as it may pose risks to health and safety if mishandled.

Upstream product

• 67-56-1 methanol 
• 94475-22-6 N-benzenesulfonyl-anthraniloyl chloride 
• 98-09-9 benzenesulfonyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 34837-67-7 2-(phenylsulfonamido)benzoic acid 
• 118-92-3 anthranilic acid 

Downstream Products

• 152342-36-4 2-(N-Mesyl-2-methoxycarbonylanilino)-5-methoxy-1,4-benzoquinone 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 312-63-0 N-(4-fluorophenyl)benzenesulfonamide 
• 52910-90-4 N-benzenesulfonyl-anthranilic acid amide 
• 824975-51-1 methyl 4-({2-[(phenylsulfonyl)amino]benzoyl}amino)benzoate 
• 34837-67-7 2-(phenylsulfonamido)benzoic acid 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors

The incidence of obesity and other diseases associated with an increased triacylglycerol mass is growing rapidly, particularly in the United States. Glycerol 3-phosphate acyltransferase (GPAT) catalyzes the ratelimiting step of glycerolipid biosynthesis, the acylation of glycerol 3-phosphate with saturated long-chain acyl-CoAs. In an effort to produce small molecule inhibitors of this enzyme, a series of benzoic and phosphonic acids was designed and synthesized. In vitro testing of this series has led to the identification of several compounds, in particular 2-(nonylsulfonamido)benzoic acid (15g), possessing moderate GPAT inhibitory activity in an intact mitochondrial assay.