1008119-09-2

Basic information

• Product Name: 4-Acetyl-N,N-dimethylbenzamide
• Synonyms: 4-Acetyl-N,N-dimethylbenzamide
• CAS NO: 1008119-09-2
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Mol File: 1008119-09-2.mol

Chemical Properties

• Boiling Point: 357.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.084±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.76±0.70(Predicted)
• CAS DataBase Reference: 4-Acetyl-N,N-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetyl-N,N-dimethylbenzamide(1008119-09-2)
• EPA Substance Registry System: 4-Acetyl-N,N-dimethylbenzamide(1008119-09-2)

Safety Data

• Hazardous Substances Data: 1008119-09-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Acetyl-N,N-dimethylbenzamide is utilized as a building block for the synthesis of a variety of pharmaceutical drugs. Its chemical structure makes it a valuable component in the creation of new medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 4-Acetyl-N,N-dimethylbenzamide serves as an intermediate in the production process, contributing to the development of various agrochemicals that are essential for agricultural applications.
Used in Dye Manufacturing:
4-Acetyl-N,N-dimethylbenzamide is also employed as an intermediate in the manufacturing of dyes, highlighting its versatility in the chemical industry for colorant production.
Used in Biological and Pharmacological Research:
4-Acetyl-N,N-dimethylbenzamide has been investigated for its potential biological and pharmacological activities, such as its analgesic properties and its possible role as an anticancer agent. However, further research is necessary to fully explore and understand its capabilities and effects in these areas.

Upstream product

• 31076-84-3 4-acetylbenzoyl chloride 
• 124-40-3 dimethyl amine 
• 33322-66-6 N,n-dimethyl-p-ethyl-benzamide 
• 13329-40-3 4-Iodoacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 99-90-1 para-bromoacetophenone 
• 127-19-5 N,N-dimethyl acetamide 
• 586-89-0 4-acetyl-benzoic acid 
• 38430-55-6 ethyl-4-acetylbenzoate 
• 506-59-2 N,N-dimethylammonium chloride 
• 18503-89-4 N,N-dimethylformamide diisopropyl acetal 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1446279-76-0 (E)-4-acetyl-N,N-dimethyl-2-(prop-1-en-1-yl)benzamide 
• 91245-82-8 1-[4-(dimethylaminomethyl)phenyl]ethanone 
• 1177423-43-6 C₂₁H₁₇N₃O₃ 
• 1177423-44-7 C₂₁H₁₉N₃O₃ 
• 1177423-65-2 C₂₀H₁₄ClN₃O₃ 
• 1177423-66-3 C₂₀H₁₆ClN₃O₃ 
• 1177423-45-8 C₂₆H₂₇N₃O₄ 
• 1177423-46-9 C₂₅H₂₅N₃O₄ 
• 1177423-67-4 C₂₅H₂₄ClN₃O₄ 
• 1177423-48-1 C₂₅H₂₅N₃O₄ 
• 1177423-47-0 C₂₅H₂₅N₃O₄ 
• 1177423-68-5 C₂₄H₂₂ClN₃O₄ 
• 1177423-76-5 C₂₅H₂₂N₄O₄ 
• 1177423-75-4 C₂₆H₂₅N₃O₄ 

Relevant articles and documents

Highly Active Cooperative Lewis Acid—Ammonium Salt Catalyst for the Enantioselective Hydroboration of Ketones

Enantiopure secondary alcohols are fundamental high-value synthetic building blocks. One of the most attractive ways to get access to this compound class is the catalytic hydroboration. We describe a new concept for this reaction type that allowed for exceptional catalytic turnover numbers (up to 15 400), which were increased by around 1.5–3 orders of magnitude compared to the most active catalysts previously reported. In our concept an aprotic ammonium halide moiety cooperates with an oxophilic Lewis acid within the same catalyst molecule. Control experiments reveal that both catalytic centers are essential for the observed activity. Kinetic, spectroscopic and computational studies show that the hydride transfer is rate limiting and proceeds via a concerted mechanism, in which hydride at Boron is continuously displaced by iodide, reminiscent to an SN2 reaction. The catalyst, which is accessible in high yields in few steps, was found to be stable during catalysis, readily recyclable and could be reused 10 times still efficiently working.

Palladium-catalyzed carbon-monoxide-free aminocarbonylation of aryl halides using N-substituted formamides as an amide source

A carbon-monoxide-free aminocarbonylation of various N-substituted formamides with aryl iodides and aryl bromides using palladium acetate and Xantphos is described. The developed methodology is applicable for a wide range of formamides and aryl halides containing different functional groups furnishing good to excellent yield of the corresponding products. N-substituted formamides are used as an amide source wherein a Vilsmeier-type intermediate plays a major role, thus eliminating the need of toxic carbon monoxide gas.

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals

We developed a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90–140 °C without any activating agents or bases in up to quantitative chemical yield. This protocol was applied to aryl bromides, aryl iodides, and trifluoromethanesulfonic acid, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates were tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate.

NOVEL GPR119 AGONIST COMPOUNDS

The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.

Copper-catalyzed amide bond formation from formamides and carboxylic acids

A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv. formamides.

A novel method for the conversion of carboxylic acids to N,N-dimethylamides using N,N-dimethylacetamide as a dimethylamine source

A simple, cost effective and environmentally benign method is reported for the preparation of N,N-dimethylamides from carboxylic acids. The versatility of the method is determined by synthesising a large number of N,N-dimethylamide derivatives. Carboxylic acids are heated at 160-165°C in N,N-dimethylacetamide solvent in the presence of1,1'-carbonyldiimidazole to afford the corresponding N,N-dimethylamides in good to excellent yields.

Sulfonylamidation of alkylbenzenes at benzylic position with p-toluenesulfonamide and 1,3-diiodo-5,5-dimethylhydantoin

Treatment of alkylbenzenes with p-toluenesulfonamide and 1,3-diiodo-5,5-dimethylhydantoin (DIH) in a small amount of carbon tetrachloride at 60 °C gave the corresponding α-p-toluenesulfonylamido)alkylbenzenes in good to moderate yields. The present reaction is a simple method for the α-sulfonylamidation of the benzylic position in alkylbenzenes.

FUSED HETEROARYL MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF

Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, ha

Therapeutic Compounds

The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.