1011-24-1

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-methoxy-
• Synonyms: 4(3H)-Quinazolinone, 2-methoxy-;2-Methoxy-3,4-dihydro-4-oxoquinazoline;2-Methoxy-4(1H)-quinazolinone
• CAS NO: 1011-24-1
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176
• Mol File: 1011-24-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 230-232℃
• Boiling Point: 303.5°Cat760mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 1.32
• Vapor Pressure: 0.00093mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-methoxy-(1011-24-1)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-methoxy-(1011-24-1)

Safety Data

• Hazardous Substances Data: 1011-24-1(Hazardous Substances Data)

Usage

General Description

4(3H)-Quinazolinone, 2-methoxy- is a chemical compound that belongs to the quinazolinone family. It has a molecular formula of C9H8N2O2 and a molecular weight of 176.17 g/mol. 4(3H)-Quinazolinone, 2-methoxy- is known for its potential biological and pharmaceutical activities, as it has been studied for its anticonvulsant, anti-inflammatory, and anticancer properties. Additionally, 4(3H)-Quinazolinone, 2-methoxy- has been investigated for its potential use as a building block in organic synthesis and medicinal chemistry. Its unique structure and diverse biological activities make it a promising compound for further research and development in the pharmaceutical industry.

InChI:InChI=1/C9H8N2O2/c1-13-9-10-7-5-3-2-4-6(7)8(12)11-9/h2-5H,1H3,(H,10,11,12)

Upstream product

• 67-56-1 methanol 
• 81559-85-5 diethyl <(3,4-dihydro-4-oxo-2-quinazolinyl)thio>bicarbamate 
• 124-41-4 sodium methylate 
• 103748-76-1 2-Benzenesulfonyl-1H-quinazolin-4-one 
• 3201-50-1 3-Methoxy-5-phenyl-1,2,4-oxadiazole 
• 4143-61-7 diethyl diazodicarboxylate 
• 13906-09-7 2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 87-25-2 2-ethoxycarbonylaniline 
• 74-89-5 methylamine 
• 116751-88-3 C₁₀H₁₂N₂O₃ 
• 607-69-2 2-chloro-4(3H)-quinazolinone 
• 13369-03-4 Cyan-imidoameisensaeuremethylester 
• 134-20-3 2-carbomethoxyaniline 
• 2050-42-2 2,4-dimethoxy-quinazoline 

Relevant articles and documents

Mesoionic 1,2,4-triazolo[4,3-c]quinazolines

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Photoinduced molecular rearrangements. The photochemistry of some 1,2,4-oxadiazoles in the presence of nitrogen nucleophiles. Formation of 1,2,4-triazoles, indazoles, and benzimidazoles

The photochemistry of some 3,5-disubstituted 1,2,4-oxadiazoles in the presence of nitrogen nucleophiles [external, such as added amines or hydrazines, or internal, such as an o-aminophenyl moiety at C(3) of the oxadiazole ring] has been investigated. In the irradiation of 5-amino-(or 5-N-substituted amino) 3-phenyl-1,2,4-oxadiazoles in the presence of aliphatic primary amines (or ammonia), photolytic species arising from heterolytic cleavage of the ring O-N bond capture the nucleophilic reagent to give open-chain intermediates, which develop into 1,2,4-triazolin-5-ones. Similarly, irradiations of 3,5-diphenyl-, 3-methoxy-5-phenyl-, and 5-methyl-3-phenyl-1,2,4-oxadiazoles gave 1,2,4-triazoles. In the same context, irradiations of representative substrates in the presence of hydrazines have been also investigated. In the irradiation of 3-(o-aminophenyl)-5-methyl-, 3-[o-(methylamino)phenyl]-5-methyl-, and 3-(o-aminophenyl)-5-phenyl-1,2,4-oxadiazoles, concomitant formation of indazoles and benzimidazoles, presumably arising from a common photolytic species, has been observed. Some mechanistic aspects have been considered, and possible applications in synthesis have been pointed out.

o.FORMYLARYLAZOMETHYLENETRIPHENYLPHOSPHORANES: A FACILE THERMALLY PROMOTED REARRANGEMENT TO 3-OXO-INDAZOLINE AND 4-OXO-DIHYDROQUINAZOLINE DERIVATIVES

The o.formylarylazomethylenetriphenylphosphoranes carrying an electron withdrawing group on the ylidic carbon undergo thermal intramolecular cyclization to 3-oxo-indazolin-2-yl-methylenephosphorane derivatives.The latter compounds, and their 1-alkyl derivatives, in turn, undergo thermal and/or acid catalyzed rearrangement to 4-oxo-1,4-dihydroquinazoline derivatives and PPh3.Some possible reaction mechanisms are discussed, and some synthetic applications of the above reactions are shown.