10175-31-2

Basic information

• Product Name: BenzeneMethanaMine, 2-chloro-N,N-diMethyl-
• Synonyms: BenzeneMethanaMine, 2-chloro-N,N-diMethyl-;2-Chloro-N,N-dimethyl-benzenemethanamine
• CAS NO: 10175-31-2
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.65128
• Mol File: 10175-31-2.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 215-219℃ at 101.33kPa
• Appearance: /
• Density: 1.06 at 20℃
• Vapor Pressure: 22-160Pa at 20-50℃
• CAS DataBase Reference: BenzeneMethanaMine, 2-chloro-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanaMine, 2-chloro-N,N-diMethyl-(10175-31-2)
• EPA Substance Registry System: BenzeneMethanaMine, 2-chloro-N,N-diMethyl-(10175-31-2)

Safety Data

• Hazardous Substances Data: 10175-31-2(Hazardous Substances Data)

Usage

General Description

"BenzeneMethanamine, 2-chloro-N,N-diMethyl-" is a chemical compound that falls under the categories of amines, aromatic amines, organochlorines, and benzenoids. Most commonly known for its use in the chemical and manufacturing industry, this compound is recognized for its several key characteristics. It has an aromatic, amine odor and is known for its potentially harmful effects if improperly handled, particularly its irritant properties that can affect various bodily systems. It is typically stored under controlled room temperature in a dry, well-ventilated area. Safety precautions include wearing appropriate protective clothing and eyewear, and ensuring good ventilation in the area where handling is being performed.

Upstream product

• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 89-98-5 2-chloro-benzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 67-56-1 methanol 
• 100-97-0 hexamethylenetetramine 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-38-9 carbon dioxide 
• 94-64-4 N-methyl-N-(2-chlorobenzyl)amine 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 64-18-6 formic acid 

Downstream Products

• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 1467-79-4 NCNMe₂ 
• 10169-24-1 (3-Chloro-2-dimethylaminomethyl-phenyl)-diphenyl-methanol 
• 952720-77-3 C₁₈H₁₈Cl₂NO⁽¹⁺⁾*Cl^(1-) 
• 1192229-96-1 2-chlorobenzyldimethylamine borane 
• 89-98-5 2-chloro-benzaldehyde 
• 57239-59-5 bis(2-chlorobenzyl) diselenide 
• 91110-67-7 1-chloro-2-(phenylsulfonylmethyl)benzene 

Relevant articles and documents

A high throughput synthesis of N,N-dimethyl tertiary amines

N,N-dimethyl tertiary amines are obtained in high yields by titanium(IV) isopropoxide mediated reductive amination of carbonyl compounds with a commercially available methanol solution of dimethylamine.

Lewis Acid-Catalyzed Reductive Amination of Aldehydes and Ketones with N,N-Dimethylformamide as Dimethylamino Source, Reductant and Solvent

A practical zinc acetate dihydrate-catalyzed reductive amination of various carbonyl compounds with N,N-dimethylformamide (DMF) as dimethylamino (Me2N) source, reductant and solvent has been developed. This reaction shows broad substrate scope,

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Simplified preparation of a graphene-co-shelled Ni/NiO@C nano-catalyst and its application in theN-dimethylation synthesis of amines under mild conditions

The development of Earth-abundant, reusable and non-toxic heterogeneous catalysts to be applied in the pharmaceutical industry for bio-active relevant compound synthesis remains an important goal of general chemical research.N-methylated compounds, as one of the most essential bioactive compounds, have been widely used in the fine and bulk chemical industries for the production of high-value chemicals. Herein, an environmentally friendly and simplified method for the preparation of graphene encapsulated Ni/NiO nanoalloy catalysts (Ni/NiO@C) was developed for the first time, for the highly selective synthesis ofN-methylated compounds using various functional amines and aldehydes under easy to handle, and industrially applicable conditions. A large number of primary and secondary amines (more than 70 examples) could be converted to the correspondingN,N-dimethylamines with the participation of different functional aldehydes, with an average yield of over 95%. A gram-scale synthesis also demonstrated a similar yield when compared with the benchmark test. In addition, it was further proved that the catalyst could easily be recycled because of its intrinsic magnetism and reused up to 10 times without losing its activity and selectivity. Also, for the first time, the tandem synthesis ofN,N-dimethylamine products in a one-pot process, using only a single earth-abundant metal catalyst, whose activity and selectivity were more than 99% and 94%, respectively, for all tested substrates, was developed. Overall, the advantages of this newly developed method include operational simplicity, high stability, easy recyclability, cost-effectiveness of the catalyst, and good functional group compatibility for the synthesis ofN-methylation products as well as the industrially applicable tandem synthesis process.

Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).