103-86-6

Usage

Uses

Used in Ophthalmic Medicine:
4-(2-aminopropyl)phenol is used as a diagnostic agent in ophthalmology for the detection and evaluation of specific eye conditions. When administered as eye drops, it helps in identifying abnormalities in the eye's structure and function, enabling accurate diagnosis and appropriate treatment.
The specific application reason for using 4-(2-aminopropyl)phenol in ophthalmic medicine is its ability to stimulate the production of tears and dilate the pupils. This allows for a more thorough examination of the eye, facilitating the detection of various conditions such as dry eye syndrome, corneal abrasions, and retinal disorders.

InChI:InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3

Upstream product

• 64-13-1 2-amino-1-(4-methyoxyphenyl)propane 
• 57736-33-1 (+/-)-4-(2-amino-propyl)-aniline 
• 658-48-0 2-amino-3-(4-hydroxy-phenyl)-2-methyl-propionic acid 
• 60-15-1 2-amino-1-phenylpropane 
• 3240-42-4 p-Hydroxy-norephedrin-HCl 
• 27566-05-8 4-(2-(benzylamino)propyl)phenol 
• 770-39-8 4-methoxyphenylacetone 
• 123-11-5 4-methoxy-benzaldehyde 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 7176-38-7 1-(4-Benzyloxyphenyl)-2-nitro-1-propen 
• 7176-39-8 2-(4-benzyloxy-phenyl)-1-methyl-ethylamine 
• 17354-63-1 4-(2-nitro-propenyl)-anisole 
• 37629-51-9 1-methoxy-4-((E)-2-nitroprop-1-enyl)benzene 
• 39755-38-9 3-(4'-methoxyphenyl)-2-methyl-propanamide 

Downstream Products

• 370-14-9 pholedrine 
• 103153-58-8 4-[2-(1-methyl-2-phenyl-ethylamino)-propyl]-phenol 
• 3673-98-1 rac. 2-(4-Hydroxy-phenyl)-1-methyl-2'-phenoxy-diaethylamin 
• 27566-05-8 4-(2-(benzylamino)propyl)phenol 
• 99-96-7 4-hydroxy-benzoic acid 
• 59481-71-9 tert-butyl N-[2-(4-hydroxyphenyl)-1-methyl-ethyl]carbamate 
• 1351781-81-1 C₁₂H₁₇NO₃ 
• 1518-89-4 (-)-Hydroxyamphetamine 
• 1693-66-9 (+)-Hydroxyamphetamine 
• 1241224-85-0 C₁₉H₂₅N₃O₂ 
• 1241565-96-7 C₁₈H₃₀N₂O₂ 
• 1281135-71-4 1-[2-(4-hydroxy-phenyl)-1-methyl-ethyl]-3-(2-thiophen-2-yl-ethyl)-urea 
• 7176-39-8 2-(4-benzyloxy-phenyl)-1-methyl-ethylamine 
• 27675-95-2 N-Acetyl-p-hydroxyamfetamin 

Relevant academic research and scientific papers

A Bioinspired Synthesis of Polyfunctional Indoles

Polyfunctional indoles bearing substituents at C5 and C6 are prevalent in natural products, pharmaceuticals, agrochemicals, and materials. Owing to the remoteness of the C5 and C6 positions, indoles of this family can be difficult to prepare, and often require multistep syntheses. Herein, we describe a concise process that converts simple derivatives of tyrosine into 5,6-difunctionalized indoles by direct oxidation of C?H, N?H, and O?H bonds. Our work draws inspiration from the biosynthetic polymerization of tyrosine to make melanin pigments, but makes an important departure to provide well-defined indole heterocycles.

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS

The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

AZETIDINE DERIVATIVES

Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used. The Royal Society of Chemistry 2011.

DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE BETA2 ADRENERGIC RECEPTOR

The present invention provides a compound of formula (I): wherein: ? R1 is a group selected from -CH2OH,-NH(CO)H and ? R2 is a hydrogen atom; or ? R1together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1and the carbon atom is bound to the carbon atom in the phenyl ring holding R2 ? R3a and R3bare independently selected from the group consisting of hydrogen atoms and C1-4alkyl groups, ? n represents an integer from 1 to 3; ? Ad represents 1-adamantyl or 2-adamantyl group, or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.

Magnesium-Catalyzed Proficient Reduction of Oximes to Amines Using Ammonium Formate

Various aldoximes and ketoximes were selectively reduced to the corresponding amines by catalytic transfer hydrogenation employing low cost magnesium powder and ammonium formate at room temperature. Many other functionalities such as halogens, -OH, -OCH3, -COOH and -CH 3 remained unaffected. The hydrogenation is fast, mild, clean, cost effective and high yielding.

Zinc/ammonium formate: A new facile system for the rapid and selective reduction of oximes to amines

Various oximes, both aldoximes and ketoximes, are selectively reduced to corresponding amines employing low cost zinc dust and ammonium formate despite presence of other functional groups such as halogens, -OH, -OCH3, -COOH, -CN, > C = C 3.

Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylethylamino)- 1-hydroxyethyl)-benzene-1,3-diol ([18F]FEFE) for the in vivo visualisation and quantification of the β2-adrenergic receptor status in lung

The 18F-labeled β2-adrenergic receptor ligand (R,R)(S,S) 5-(2-(2-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylethylamino)- 1-hydroxyethyl)-benzene-1,3-diol, a derivative of the original highly selective racemic fenoterol, was synthesized in an overall radiochemical yield of 20% after 65 min with a radiochemical purity higher than 98%. The specific activity was in the range of 50-60 GBq/μmol. In vitro testing of the non-radioactive fluorinated fenoterol derivative with isolated guinea pig trachea was conducted to obtain an IC50 value of 60 nM. Preliminary ex vivo organ distribution and in vivo experiments with positron emission tomography (PET) on guinea pigs were performed to study the biodistribution as well as the displacement of the radiotracer to prove specific binding to the β2-receptor.