30489-48-6

Upstream product

• 38922-74-6 2-(4-chlorophenyl)imidazolo[1,2-a]pyridine 
• 107-21-1 ethylene glycol 
• 504-29-0 2-aminopyridine 
• 637-87-6 1-Chloro-4-iodobenzene 
• 6188-43-8 imidazo[1,2-a]pyridine-3-carbaldehyde 
• 1284210-49-6 tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate 
• 5857-45-4 3-methylimidazo[1,2-α]pyridine 
• 117459-95-7 N-(prop-2-yn-1-yl)pyridin-2-amine 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 30493-06-2 2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 99-91-2 para-chloroacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 1338469-65-0 methyl 2-(4-chloro-phenyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 22027-53-8 methyl 3-(4-chlorophenyl)-3-oxopropanoate 

Downstream Products

• 1417910-24-7 C₁₄H₁₀ClN₅ 
• 1417910-34-9 2-(4-chlorophenyl)-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-36-1 2-(4-chlorophenyl)-3-((4-p-tolyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-38-3 3-((4-benzyl-1H-1,2,3-triazol-1-yl)methyl)-2-(4-chlorophenyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-39-4 2-(4-chlorophenyl)-3-((4-propyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 103844-86-6 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N-methylbutyramide 
• 103845-12-1 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl)methyl)butyramide 

Relevant academic research and scientific papers

KIO4-mediated Selective Hydroxymethylation/Methylenation of Imidazo-Heteroarenes: A Greener Approach

Herein, we report a KIO4-mediated, sustainable and chemoselective approach for the one-pot C(sp2)?H bond hydroxymethylation or methylenation of imidazo-heteroarenes with formaldehyde, generated in situ via the oxidative cleavage of ethylene glycol or glycerol (renewable reagents) through the Malaprade reaction. In the presence of ethylene glycol, a series of 3-hydroxymethyl-imidazo-heteroarenes was obtained in good to excellent yields. These compounds are important intermediates to access pharmaceutical drugs, e.g., Zolpidem. Furthermore, by using glycerol, bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives were selectively obtained in good to excellent yields.

SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF

The present application relates to novel imidazopyridinyl-or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

Silver-catalyzed cyclization of N-(prop-2-yn-1-yl)pyridin-2-amines

We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl)pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines. The isomerization reactions proce

Exploration of the CuAAC reaction for the synthesis of novel 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines

The archetypical CuAAC click chemistry is explored to assemble diverse 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines. The approach is simple, general, and environmentally benign to generate a library of novel triazolo-imidazo[1,2- a]pyridine derivatives in good yield (30-90%).

Synthesis of imidazo[1,2-a]pyridines by the bis(acetyloxy)(phenyl)- λ3-iodane-Mediated oxidative coupling of 2-aminopyridines with β-keto esters and 1,3-diones

Imidazo[1,2-a]pyridine-3-carboxylates can be prepared directly from 2-aminopyridines and β-keto esters by using bis(acetyloxy)(phenyl)- λ3-iodane as an oxidant and boron trifluoride etherate as a catalyst. The amount of catalyst plays a key rol