5857-45-4

Basic information

• Product Name: 3-METHYL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 3-METHYL-IMIDAZO[1,2-A]PYRIDINE;IMIDAZO[1,2-A]PYRIDINE, 3-METHYL-
• CAS NO: 5857-45-4
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.17
• Mol File: 5857-45-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHYL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-IMIDAZO[1,2-A]PYRIDINE(5857-45-4)
• EPA Substance Registry System: 3-METHYL-IMIDAZO[1,2-A]PYRIDINE(5857-45-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 5857-45-4(Hazardous Substances Data)

Usage

General Description

3-Methyl-imidazo[1,2-a]pyridine, also known as 6-Methylimidazo[1,2-a]pyridine or 6-MeIP, is a heterocyclic aromatic amine compound that is commonly found in cooked meat and fish. It is formed during the high-temperature cooking process, such as grilling or frying, and is considered a carcinogenic substance. 3-Methyl-imidazo[1,2-a]pyridine has been identified as a potent carcinogen in animal studies, particularly in relation to the development of various types of cancer, including lung, colon, and prostate cancer. It is important to limit the consumption of food containing high levels of 3-Methyl-imidazo[1,2-a]pyridine and to practice healthy cooking methods to reduce exposure to this harmful chemical.

Upstream product

• 108245-63-2 [2]pyridylamino-acetone 
• 108-24-7 acetic anhydride 
• 117459-94-6 2-(N-formyl-N-prop-2'-inyl)aminopyridin 
• 504-29-0 2-aminopyridine 
• 123-38-6 propionaldehyde 
• 117459-95-7 N-(prop-2-yn-1-yl)pyridin-2-amine 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 1284210-80-5 C₁₀H₁₀N₂O 
• 1284210-49-6 tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate 
• 34813-97-3 2-(formylamino)pyridine 
• 86602-43-9 1-(2-pyridinylamino)-2-nitroprene 
• 111961-50-3 (2-methyl-[1,3]dioxolan-2-ylmethyl)-[2]pyridyl-amine 

Downstream Products

• 6188-43-8 imidazo[1,2-a]pyridine-3-carbaldehyde 
• 30489-43-1 3-hydroxymethylimidazo[1,2-a]pyridine 
• 30493-06-2 2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 30489-48-6 (2-(4-chlorophenyl)imidazo [1,2-a] pyridin-3-yl)methanol 
• 103845-12-1 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl)methyl)butyramide 
• 103844-86-6 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N-methylbutyramide 

Relevant articles and documents

Metal- and base-free synthesis of imidazo[1,2-: A] pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2-a]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in a highly atom-economical fashion through oxidative annulation under metal- and base-free conditions. Besides arylacetaldehydes, aliphatic aldehydes were also compatible with this system to deliver the alkyl-substituted imidazo[1,2-a]pyridines in excellent yields with the capability of gram-scale synthesis.

Synthesis of imidazo[1,2-a]pyridines: "Water-mediated" hydroamination and silver-catalyzed aminooxygenation

Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag

A base promoted cyclization of N-propargylaminopyridines. Synthesis of imidazo[1,2-a]pyridine derivatives

Chemical equations presented. A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a]pyridine derivatives. The reactions were carried out with a small excess of base,