104-19-8

Basic information

• Product Name: 1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE
• Synonyms: 1-METHYL-4-DIMETHYLAMINOETHYLPIPERAZINE;1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE;N,N-4-TRIMETHYL-1-PIPERAZINE ETHANAMINE;1-(2-(dimethylamino)ethyl)-4-methyl-piperazin;1-(2-(N,N-Dimethylamino)ethyl)-4-methylpiperazine;1-Piperazineethanamine, N,N,4-trimethyl-;dimethylaminoethylmethylpiperazine;kaolizer8
• CAS NO: 104-19-8
• Molecular Formula: C₉H₂₁N₃
• Molecular Weight: 171.28
• EINECS: 203-183-7
• Product Categories: PIPERIDINE
• Mol File: 104-19-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 96 °C / 12mmHg
• Flash Point: 100°C(lit.)
• Appearance: /
• Density: 0,89 g/cm3
• Vapor Pressure: 0.224mmHg at 25°C
• Refractive Index: 1.4630-1.4660
• PKA: 9.50±0.28(Predicted)
• Water Solubility: Completely miscible in water
• CAS DataBase Reference: 1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE(104-19-8)
• EPA Substance Registry System: 1-(2-DIMETHYLAMINOETHYL)-4-METHYLPIPERAZINE(104-19-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2922
• RTECS: TL6125000
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 104-19-8(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

InChI:InChI=1/C9H21N3/c1-10(2)4-7-12-8-5-11(3)6-9-12/h4-9H2,1-3H3

Upstream product

• 59325-11-0 ethyl 4-methyl-1-piperazinecarboxylate 
• 140-31-8 aminoethylpiperazine 
• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 817-09-4 tris-(2-chloroethyl)amine hydrochloride 
• 124-40-3 dimethyl amine 
• 5450-74-8 1,4-dimethyl-1,4-diazabicyclo[2.2.2]octane-1,4-diium dibromide 
• 555-77-1 tris-(2-chloro-ethyl)-amine 
• 926-64-7 N,N-Dimethylamino acetonitrile 
• 55-86-7 mechlorethamine hydrochloride 
• 109-01-3 1-methyl-piperazine 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 

Relevant articles and documents

METHOD OF PRODUCING TERTIARY AMINE OR TERTIARY AMINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method of producing tertiary amine or tertiary amine derivative with high selectivity. SOLUTION: In the method of producing tertiary amine or tertiary amine derivative, a reaction system including: an organic chemical raw material containing at least one kind of group selected from -NH2, -NH2 HCl, >NH and >NH HCl, a nitrogen atom contained in the group bounding to a carbon atom; aliphatic alcohol having 1 to 20 carbon atoms; and a catalyst where a carrier containing titanium oxide carries a silver component (metal silver or silver compound), is irradiated with light, and the group in the organic compound raw material is converted to -NR02 or >NR0, ( R0 is an aliphatic hydrocarbon group having 1 to 20 carbon atoms derived from the aliphatic alcohol). The percentage content of the silver in the catalyst is 0.5 to 10 mass% with respect to the titanium oxide. COPYRIGHT: (C)2015,JPOandINPIT

Transalkylation Reaction. Homogeneous Catalytic Formation of C-N Bonds

We have performed kinetic and mechanistic studies on homogeneous ruthenium-catalyzed transalkylation of tertiary amines.From these studies we have derived a kinetic expression for transalkylation catalysis based on initial reaction rates.We find that transalkylation proceeds most efficiently in alcoholic solvents (e.g., MeOH or EtOH), under a slight pressure of CO, with a mixed-metal, iron-ruthenium catalyst.The mechanism appears to be in one which a metal cluster of at least two and most probably three atoms binds the amine through insertion into an α C-H bond to give a metallazacyclopropane or metal-iminium complex.Nucleophilic attack by free amine on the complex, or an immediate derivative, follows, and subsequent rearrangement of the intermediate formed gives transalkylation products.The catalyst system has been tested as a synthetic tool for the oligomerization and cyclization of tertiary diamines.These preliminary studies have been quite succesful.Thus, N,N,N',N'-tetramethylethylenediamine can be transformed into Me3N and N,N'-dimethylpiperazine with good conversion and high selectivity.N,N,N',N'-Tetraethylethylenediamine can be transformed into Et3N and the linear, perethyl, ethylenediamine dimer, trimer, tetramer, and pentamer with excellent conversion.