104505-71-7

Upstream product

• 102-92-1 cinnamoyl chloride 
• 137-07-5 2-amino-benzenethiol 
• 621-82-9 Cinnamic acid 
• 29476-15-1 2,3-dihydro-4-methylthio-2-phenyl-1,5-benzothiazepine 
• 29476-22-0 2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one 
• 131188-18-6 (E)-N-[2-(1-Methoxy-ethylsulfanyl)-phenyl]-3-phenyl-acrylamide 
• 100-42-5 styrene 
• 104-55-2 3-phenyl-propenal 
• 104-94-9 4-methoxy-aniline 
• 95-16-9 1,3-Benzothiazole 
• 98518-01-5 thiocinnamic acid 
• 77116-72-4 (2-iodophenylimino)triphenylphosphorane 
• 104-54-1 3-Phenylpropenol 
• 136-95-8 2-amino-benzthiazole 

Downstream Products

• 6305-31-3 2-(2-phenylethyl)-1,3-benzothiazole 
• 1485-79-6 3-methyl-2-styryl-benzothiazolium; methyl sulfate 
• 1485-77-4 2-(1,2-dibromo-2-phenyl-ethyl)-benzothiazole 
• 137-07-5 2-amino-benzenethiol 
• 65-85-0 benzoic acid 
• 1557-21-7 2-(3-methyl-3H-benzothiazol-2-ylidene)-1-phenyl-ethanol 
• 1557-22-8 2-(1-bromo-2-ethoxy-2-phenyl-vinyl)-benzothiazole 
• 1788-58-5 2-(2-ethoxy-2-phenyl-ethylidene)-3-methyl-2,3-dihydro-benzothiazole 
• 1788-56-3 3,3′-dimethyl-9-phenylthiacarbocyanine iodide 
• 1788-57-4 2-(3-carboxy-2-phenyl-propyl)-3-methyl-benzothiazolium; chloride 
• 1557-01-3 2-(1,1,2-tribromo-2-phenyl-ethyl)-benzothiazole 
• 47619-85-2 [2-(3-methyl-3H-benzothiazol-2-ylidene)-1-phenyl-ethyl]-malonic acid diethyl ester 
• 1557-20-6 3-methyl-4'-phenyl-4',5'-dihydro-3H,3'H-spiro[benzothiazole-2,2'-pyran]-6'-one 
• 1483-29-0 2-(1-bromo-2-phenyl-vinyl)-benzothiazole 

Relevant academic research and scientific papers

Synthesis of 2-substituted benzothiazoles by visible light-driven photoredox catalysis

An efficient method for synthesis of the widely applicable 2-substituted benzothiazoles has been developed. The process requires only 0.1 mol% [Ru(bpy)3Cl2], O2, and visible light irradiation with substrates: 2-aminothiophenol and a variety of aldehydes. We established an oxidative quenching of the photoredox catalyst as being the key process in this photoelectrocatalytic cycle. Copyright

Photo-induced intermolecular electron transfer from donating amines to accepting diarylethylenes in different solvents

The fluorescence quenching of newly synthesized diarylethylenes by some aliphatic and aromatic amines has been carried out at room temperature in solvents of various polarities and viscosities including acetonitrile, methanol, ethanol, and cyclohexane usi

Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the synthesis of 2-arylbenzothiazoles

The condensation reaction of 2-aminothiophenol with aldehydes catalyzed by 1 mol % trichloroisocyanuric acid (TCCA) was investigated. As a result, a set of diverse 2-arylbenzothiazoles were obtained in good to excellent yields at room temperature. Copyrig

Lawesson's reagent and microwaves: A new efficient access to benzoxazoles and benzothiazoles from carboxylic acids under solvent-free conditions

Lawesson's reagent acts as an efficient promoter in the solvent-free microwave-assisted synthesis of 2-substituted benzoxazoles from carboxylic acids and 2-aminophenol, and thus, constitutes a general synthetic method for these compounds. This new application of Lawesson's reagent is valid also for benzothiazoles with very high efficiency level. A variety of aromatic, heteroaromatic and aliphatic carboxylic acids react under the conditions developed with good yields in all cases. Thiobenzoic acid is a good alternative for microwave-assisted synthesis of 2-phenylbenzoxazole and 2- phenylbenzothiazole in the absence of solvents. Georg Thieme Verlag Stuttgart.

Catalytic asymmetric addition of Grignard reagents to alkenyl-substituted aromatic N-heterocycles

Catalytic asymmetric conjugate addition reactions represent a powerful strategy to access chiral molecules in contemporary organic synthesis. However, their applicability to conjugated alkenyl-N-heteroaromatic compounds, of particular interest in medicinal chemistry, has lagged behind applications to other substrates.We report a highly enantioselective and chemoselective catalytic transformation of a wide range of b-substituted conjugated alkenyl-N-heteroaromatics to their corresponding chiral alkylated products.This operationally simple methodology can introduce linear, branched, and cyclic alkyl chains, as well as a phenyl group, at the β-carbon position.The key to this success was enhancement of the reactivity of alkenyl-heteroaromatic substrates via Lewis acid activation, in combination with the use of readily available and highly reactive Grignard reagents and a copper catalyst coordinated by a chiral chelating diphosphine ligand.

Pentafluorophenylammonium Triflate: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2-Arylbenzothiazole and 2-Arylbenzothiazoline Derivatives in a Green Chemical Approach

In this work, one pot, simple and environmentally benign effective synthesis of 2-substituted benzothiazole and benzothiazoline derivatives are described in presence of PFPAT (pentafluorophenylammonium triflate) catalyst in water successfully. A series of benzothiazole derivative were synthesized by the reaction between 2-aminothiophenol and various aldehydes in good yields. Recyclability of the catalyst is observed for four times without loss of its activity in aqueous medium.

Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions

The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.

Synthesis of some benzothiazoles by developing a new protocol using urea nitrate as a catalyst and their antimicrobial activities

The present communication demonstrates the development of urea nitrate as an effective and efficient catalyst for the synthesis of some 2-substituted benzothiazoles. Instant progress of reaction at room temperature under solvent-free condition, very high catalytic activity, inexpensive, clean reaction profile, operational simplicity, large-scale synthesis and appreciable yields are the main advantages of this protocol. These synthesized benzothiazoles have been evaluated for their antibacterial and antifungal activities against Gram-positive bacterium (Bacillus subtilis MTCC 121); two Gram-negative bacteria (Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741) and two fungi (Candida albicans MTCC 3017 and Saccharomyces cerevisiae MTCC 170). Compound 3n was found the most active against all the tested microbes.

Role of graphene oxide as a heterogeneous acid catalyst and benign oxidant for synthesis of benzimidazoles and benzothiazoles

We report the synthesis of benzothiazoles and benzimidazoles using graphene oxide as an effective catalyst with good yields and easy recyclability. Graphene oxide plays the dual role of a metal-free acid catalyst and an oxidizing agent. The mechanism of a

METHOD FOR PREPARING BENZOTHIAZOLE AND DERIVATIVES

The present invention relates to a method for preparing benzothiazole and derivatives of the same and, more specifically, to a method for preparing benzothiazole derivatives using aminothiophenol derivatives, aldehyde, oxygen, and photocatalyst under the condition in which visible rays are radiated to react in a simple condition while synthesizing benzothiazole derivatives having various forms in high yield.COPYRIGHT KIPO 2015