10478-33-8

Basic information

• Product Name: N-(2-Propynyl)succinimide
• Synonyms: N-(2-Propynyl)succinimide;1-(prop-2-ynyl)pyrrolidine-2,5-dione;N-(2-Propynyl)succinimide;2,5-Pyrrolidinedione, 1-(2-propynyl)-;1-(prop-2-yn-1-yl)pyrrolidine-2,5-dione
• CAS NO: 10478-33-8
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.13598
• EINECS: -0
• Mol File: 10478-33-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 51.0 to 55.0 °C
• Boiling Point: 237°C(lit.)
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(2-Propynyl)succinimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Propynyl)succinimide(10478-33-8)
• EPA Substance Registry System: N-(2-Propynyl)succinimide(10478-33-8)

Safety Data

• Hazardous Substances Data: 10478-33-8(Hazardous Substances Data)

Usage

General Description

N-(2-Propynyl)succinimide, also known as PSI, is a chemical compound with the molecular formula C7H7NO2. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. PSI is primarily used as a reactive intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its specific properties, such as its ability to readily undergo nucleophilic substitution reactions, make it a valuable building block in organic synthesis. Additionally, it is known for its potential application in the development of new materials and as a reagent in chemical research. However, due to its reactivity and potentially hazardous nature, proper handling and storage procedures should be followed when working with N-(2-Propynyl)succinimide.

Upstream product

• 123-56-8 Succinimide 
• 107-19-7 propargyl alcohol 
• 106-96-7 propargyl bromide 
• 209395-32-4 N-propargylmaleimide 
• 37912-62-2 sodium succinimide 
• 50433-20-0 potassium succinimide 
• 170697-90-2 5-ethenyl-5-hydroxy-1-propargyl-2-pyrrolidinone 
• 110-15-6 succinic acid 
• 2450-71-7 Propargylamine 

Downstream Products

• 135705-03-2 1-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-but-2-ynyl]-pyrrolidine-2,5-dione 
• 7591-19-7 DKJ 21 
• 3854-03-3 N-(4-Pyrrolidino-2-butinyl)-succinimid 

Relevant articles and documents

Stereocontrolled formation of epoxy peroxide functionality appended to a lactam ring

The action of tert-butyl hydroperoxide and tin(IV) chloride upon allylic alcohols containing a lactam ring leads mainly to epoxy alkyl peroxides with high diastereoselection. Both the stereochemistry and the products formed are in marked contrast to the r

Double transfer of chirality in organocopper-mediated bis(alkylating) cycloisomerization of enediynes

An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo-, regio-, diastereo-, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central-to-axial-to- central) is observed. Double duty: An original synthesis of chiral benzofulvenes was developed through the highly chemo-, regio-, diastereo-, and enantioselective double transfer of alkyl groups to electrophilic enediynes. This organocopper-triggered cycloisomerization proceeds with double transfer of chirality (central-to-axial-to-central).

Synthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors

A new series of N-heteroarylsubstituted triazolosulfonamide compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. Compounds (3 a-k) were prepared by propargylation of N-heteroaryl compounds. Compound 5 was obtained from sulfanilamide and sodium nitrite followed by addition of sodium azide. The products (6 a-k) were synthesized from compounds 3 and 5. The results showed that all the synthesized compounds were inhibited the CA isoenzymes activity. Figure 6a (IC50 = 0.52 μM for hCA I and 0.34 μM for hCA II) has the most inhibitory effect among the synthesized compounds.

Supported copper (I) catalyst from fish bone waste: An efficient, green and reusable catalyst for the click reaction toward N-substituted 1,2,3-TRIAZOLES

An eco-efficient, green, and multi-gram procedure is presented for one-pot multicomponent synthesis of N-substituted 1,2,3-triazoles by using waste fishbone powders supported CuBr (FBPs-CuBr) as catalyst. FBPs-CuBr is found to be an efficient heterogeneous catalyst and a series of 1,2,3-triazoles are obtained in moderate to excellent yields in water under MW irradiation (70–98%). It can be separated conveniently by a simple filtration and reused at least seven consecutive runs with a slight drop in the product yields. Furthermore, the desired product still could be obtained in 80% yield when the scale of the reaction was increased to 40.0 mmol.

Versatile and sustainable synthesis of cyclic imides from dicarboxylic acids and amines by Nb2O5 as a base-tolerant heterogeneous lewis acid catalyst

Catalytic condensation of dicarboxylics acid and amines without excess amount of activating reagents is the most atom-efficient but unprecedented synthetic method of cyclic imides. Here we present the first general catalytic method, proceeding selectively and efficiently in the presence of a commercial Nb2O5 as a reusable and base-tolerant heterogeneous Lewis acid catalyst. The method is effective for the direct synthesis of pharmaceutically or industrially important cyclic imides, such as phensuximide, N-hydroxyphthalimide (NHPI), and unsubstituted cyclic imides from dicarboxylic acid or anhydrides with amines, hydroxylamine, or ammonia.