10487-92-0

Usage

Uses

Used in Pharmaceutical Synthesis:
[R,(-)]-α-(Acetyloxy)hydratropic acid is used as an intermediate in the synthesis of various pharmaceuticals due to its unique chemical properties and potential therapeutic applications.
Used in Local Anesthetic Applications:
In the medical field, [R,(-)]-α-(Acetyloxy)hydratropic acid is used as a potential local anesthetic, leveraging its anesthetic properties and structural similarity to cocaine for effective pain relief during medical procedures.
Used in Neurological Treatment Research:
[R,(-)]-α-(Acetyloxy)hydratropic acid is used as a research compound for the development of treatments for neurological conditions such as Parkinson's disease. Its ability to affect dopamine levels in the brain makes it a promising candidate for further study and potential therapeutic applications.
Used in Dopamine Reuptake Inhibition Research:
In the field of neuroscience, [R,(-)]-α-(Acetyloxy)hydratropic acid is used as a potent dopamine reuptake inhibitor, which can be valuable in understanding the role of dopamine in various brain functions and disorders, as well as in the development of new medications targeting dopamine pathways.

InChI:InChI=1/C11H12O4/c1-8(12)15-11(2,10(13)14)9-6-4-3-5-7-9/h3-7H,1-2H3,(H,13,14)

Upstream product

• 116064-56-3 1-phenyl-1-(tributylstannyl)ethyl acetate 
• 124-38-9 carbon dioxide 
• 515-30-0 2-phenyllactic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 75-07-0 acetaldehyde 
• 64-19-7 acetic acid 
• 98-86-2 acetophenone 
• 10501-31-2 methyl 2-acetoxy-2-phenylpropionate 
• 23236-70-6 dl-2-Phenyl-2-acetoxypropionylchlorid 
• 88292-44-8 (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate 
• 88292-45-9 (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (R)-2-hydroxy-2-phenylpropanoate 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Synthesis of degradable and chemically recyclable polymers using 4,4-disubstituted five-membered cyclic ketene hemiacetal ester (CKHE) monomers

Novel degradable and chemically recyclable polymers were synthesized using five-membered cyclic ketene hemiacetal ester (CKHE) monomers. The studied monomers were 4,4-dimethyl-2-methylene-1,3-dioxolan-5-one (DMDL) and 5-methyl-2-methylene-5-phenyl-1,3-dioxolan-4-one (PhDL). The two monomers were synthesized in high yields (80-90%), which is an attractive feature. DMDL afforded its homopolymer with a relatively high molecular weight (Mn>100?000, whereMnis the number-average molecular weight). DMDL and PhDL were copolymerized with various families of vinyl monomers,i.e., methacrylates, acrylates, styrene, acrylonitrile, vinyl pyrrolidinone, and acrylamide, and various functional methacrylates and acrylate. Such a wide scope of the accessible polymers is highly useful for material design. The obtained homopolymers and random copolymers of DMDL degraded in basic conditions (in the presence of a hydroxide or an amine) at relatively mild temperatures (room temperature to 65 °C). The degradation of the DMDL homopolymer generated 2-hydroxyisobutyric acid (HIBA). The generated HIBA was recovered and used as an ingredient to re-synthesize DMDL monomer, and this monomer was further used to re-synthesize the DMDL polymer, demonstrating the chemical recycling of the DMDL polymer. Such degradability and chemical recyclability of the DMDL polymer may contribute to the circular materials economy.

Synthesis of arylglycine and mandelic acid derivatives through carboxylations of α-amido and α-acetoxy stannanes with carbon dioxide

Incorporation reactions of carbon dioxide (CO2) with N-Boc-α-amido and α-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected α-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. α-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of α-tertiary and α-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-α- amido stannanes was transferred with up to 90% inversion of configuration at 100 °C.

Phenyl alpha acyloxyalkanoic acids, derivatives and their therapeutic use

Therapeutic as well as preventative measures to improve the cosmetic conditions or to alleviate the symptoms of dermatologic disorders with phenyl alpha acyloxyalkanoic acids and derivatives is disclosed. The cosmetic conditions and dermatologic disorders