10488-25-2

Basic information

• Product Name: Cyclohexanol, 2-(1-methylethyl)-, cis-
• CAS NO: 10488-25-2
• Molecular Formula: C9H18O
• Molecular Weight: 142.241
• Mol File: 10488-25-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 2-(1-methylethyl)-, cis-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 2-(1-methylethyl)-, cis-(10488-25-2)
• EPA Substance Registry System: Cyclohexanol, 2-(1-methylethyl)-, cis-(10488-25-2)

Safety Data

• Hazardous Substances Data: 10488-25-2(Hazardous Substances Data)

Upstream product

• 88-69-7 2-(1-methylethyl)phenol 
• 644-35-9 5-propylphenol 
• 1004-77-9 2-isopropylcyclohexanone 
• 555-31-7 aluminum isopropoxide 
• 96-07-1 (+/-)-trans-2-Isopropyl-cyclohexanol 
• 67-63-0 isopropyl alcohol 
• 67-64-1 acetone 
• 64-19-7 acetic acid 
• 1745-81-9 o-Allylphenol 
• 64-17-5 ethanol 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 94-65-5 2-(n-propyl)cyclohexanone 
• 822-87-7 2-Chlorocyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 96-07-1 (+/-)-trans-2-Isopropyl-cyclohexanol 
• 1004-77-9 2-isopropylcyclohexanone 
• 1975-32-2 (R)-2-isopropylcyclohexanone 
• 98102-91-1 (R)(+)-1r-Isopropyl-cyclohexanol-(2t) 
• 5846-43-5 cis-2-Propyl-cyclohexanol 
• 98102-89-7 (-) Trans 2-isopropyl cyclohexanol 
• 98102-90-0 (-) Cis 2-isopropyl cyclohexanol 
• 94-65-5 2-(n-propyl)cyclohexanone 

Relevant articles and documents

(Poly)cationic λ3-Iodane-Mediated Oxidative Ring Expansion of Secondary Alcohols

Herein, a simplified approach to the synthesis of medium-ring ethers through the electrophilic activation of secondary alcohols with (poly)cationic λ3-iodanes (N-HVIs) is reported. Excellent levels of selectivity are achieved for C–O bond migration over established α-elimination pathways, enabled by the unique reactivity of a novel 2-OMe-pyridine-ligated N-HVI. The resulting hexafluoroisopropanol (HFIP) acetals are readily derivatized with a range of nucleophiles, providing a versatile functional handle for subsequent manipulations. The utility of this methodology for late-stage natural product derivatization was also demonstrated, providing a new tool for diversity-oriented synthesis and complexity-to-diversity (CTD) efforts. Preliminary mechanistic investigations reveal a strong effect of alcohol conformation on the reactive pathway, thus providing a predictive power in the application of this approach to complex molecule synthesis.

Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single C-H activation step

Regio- and stereoselective oxidative hydroxylation of achiral or chiral organic compounds mediated by synthetic reagents, catalysts, or enzymes generally leads to the formation of one new chiral center that appears in the respective enantiomeric or diastereomeric alcohols. By contrast, when subjecting appropriate achiral compounds to this type of C-H activation, the simultaneous creation of two chiral centers with a defined relative and absolute configuration may result, provided that control of the regio-, diastereo-, and enantioselectivity is ensured. The present study demonstrates that such control is possible by using wild type or mutant forms of the monooxygenase cytochrome P450 BM3 as catalysts in the oxidative hydroxylation of methylcyclohexane and seven other monosubstituted cyclohexane derivatives.

Stereoselective hydrogenation of simple ketones catalyzed by ruthenium(II) complexes

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