105900-59-2

Upstream product

• 14898-52-3 methyl 3-amino-3-phenylpropanoate 
• 108-24-7 acetic anhydride 
• 72569-96-1 methyl (Z)-3-acetylamino-3-phenylacrylate 
• 136744-88-2 (E)-methyl 3-acetamido-3-phenyl-2-propenoate 
• 70272-01-4 methyl 3-amino-3-phenylacrylate 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 67-56-1 methanol 
• 1426822-57-2 C₁₃H₁₄F₃NO₃ 
• 100-52-7 benzaldehyde 
• 40638-98-0 (R/S)-3-(acetylamino)-3-phenylpropanoic acid 
• 333380-82-8 N-((S)-1-phenylbut-3-enyl)acetamide 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 136744-94-0 3-ethylamino-3-phenyl-1-propanol 
• 67654-57-3 methyl (R)-3-acetamido-3-phenylpropanoate 
• 67654-57-3 methyl (S)-3-acetylamino-3-phenylpropionate 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 117020-31-2 (R)-N-acetyl-3-amino-3-phenylpropionic acid 

Relevant academic research and scientific papers

Rhodium-catalyzed asymmetric hydrogenation of functionalized olefins using monodentate spiro phosphoramidite ligands

Novel chiral monodentate phosphorus ligands, SIPHOS, were conveniently synthesized from 1,1′-spirobiindane-7,7′-diol. The Rh complexes of SIPHOS can catalyze the hydrogenation of α-dehydroamino esters in mild conditions, providing α-amino acid derivatives

Preparation and asymmetric hydrogenation of β-aryl-substituted β-acylaminoacrylates

The Rh-catalyzed asymmetric hydrogenation of β-aryl-substituted (E)-β-acylaminoacrylates, which were isolated for the first time, with, for example [Rh{(R,R)- (Et-FerroTANE)}(nbd)]+ as catalyst (see picture) proceeds under very mild conditions

Phosphite-thioether/selenoether Ligands from Carbohydrates: An Easily Accessible Ligand Library for the Asymmetric Hydrogenation of Functionalized and Unfunctionalized Olefins

A large family of phosphite-thioether/selenoether ligands has been easily prepared from accessible L-(+)-tartaric acid and D-(+)-mannitol and applied in the M-catalyzed (M=Ir, Rh) asymmetric hydrogenation of a broad number of substrates (46 in total). Its highly modular architecture has been crucial to maximize the catalytic performance. Improving most of the reported approaches, this ligand family presents a broad substrate scope. By selecting the ligand parameters high enantioselectivities (ee's up to 99 %) have therefore been achieved in a broad range of both, functionalized and unfunctionalized substrates. Interestingly, both enantiomers of the hydrogenation products can be usually achieved by changing the ligand parameters.

Are β-acylaminoacrylates hydrogenated in the same way as α-acylaminoacrylates?

Five catalyst-substrate complexes of the type [Rh(chiral ligand)(β-dehydroamino acid derivative)]BF4 were characterized for the first time by X-ray analysis (see example). Low-temperature NMR spectroscopy proved that three of these complexes ar

Nickel-catalyzed enantioselective hydrogenation of β-(acylamino)acrylates: Synthesis of chiral β-amino acid derivatives

The nickel-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates has been developed, affording chiral β-amino acid derivatives with excellent yields (95-99% yield) and enantioselectivities (97-99% ee). With the Ni-Binapine system, high enantioselectivities (98-99% ee) have also been obtained in the hydrogenation of Z/E isomeric mixtures of β-alkyl and β-aryl β-(acylamino)acrylates. The synthesis of chiral β-amino acid derivatives on a gram scale has also been achieved with 0.2 mol % catalyst loading.

Highly efficient synthesis of chiral β-amino acid derivatives via asymmetric hydrogenation

(Formula Presented) The Rh-TangPhos complex is an efficient hydrogenation catalyst for making chiral β-amino acid derivatives. With the Rh-TangPhos system, high enantioselectivities (up to 99.6%) and turnover numbers have been obtained in the hydrogenatio

Lipases in β-dipeptide synthesis in organic solvents

A number of β-dipeptides were prepared by two-step lipase-catalyzed reactions where N-acetylated β-amino esters were first activated as 2,2,2-trifluoroethyl esters with Candida antarctica lipase B (CAL-B). The activated esters were then used to acylate a

Synthesis of monodentate chiral spiro phosphonites and the electronic effect of ligand in asymmetric hydrogenation

New monodentate chiral phosphonites were synthesized from enantiomerically pure 1,1′-spirobiindane-7,7′-diol. The phosphonites 2 were efficient ligands for the Rh-catalyzed asymmetric hydrogenation of α- and β-dehydroamino acid derivatives, providing the

OPTICALLY ACTIVE BISPHOSPHINO METHANE AND PRODUCTION METHOD THEREFOR, AND TRANSITION METAL COMPLEX AND ASYMMETRIC CATALYST

PROBLEM TO BE SOLVED: To provide a novel optically active bisphosphine methane that is useful as a ligand for an asymmetric catalyst, has excellent oxidation resistance in the air, and is easy to handle, and to provide a transition metal complex using, as

Chiral ferrocene-indole diphosphine ligand as well as preparation method and application thereof

The invention relates to a chiral ferrocene-indole diphosphine ligand as well as a preparation method and application thereof. The specific preparation method comprises the following steps: dissolving an indole compound and a chiral ferrocene phosphine ac