10601-73-7

Basic information

• Product Name: N-(3-Hydroxypropyl)acetamide
• Synonyms: N-(3-Hydroxypropyl)acetamide;acetamide, N-(3-hydroxypropyl)-;N-(3-hydroxypropyl)acetamide(SALTDATA: FREE);3-(Acetylamino)propan-1-ol, 1-[(3-Hydroxyprop-1-yl)amino]ethan-1-one;N-(3-Hydroxyprop-1-yl)acetamide;N-(3-hydroxypropyl)ethanamide
• CAS NO: 10601-73-7
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• Mol File: 10601-73-7.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-Hydroxypropyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Hydroxypropyl)acetamide(10601-73-7)
• EPA Substance Registry System: N-(3-Hydroxypropyl)acetamide(10601-73-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 10601-73-7(Hazardous Substances Data)

Usage

General Description

N-(3-Hydroxypropyl)acetamide is a chemical compound that falls under the category of acetamides. It is produced through the reaction between 3-chloro-1,2-propane-diol and acetamide. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. N-(3-Hydroxypropyl)acetamide has a hydroxypropyl group attached to the acetamide functional group, which gives it potential applications in drug delivery and controlled release systems. It also has the potential to be used as a solvent and a reagent in various chemical reactions within the pharmaceutical and agricultural industries. Overall, N-(3-Hydroxypropyl)acetamide is a versatile compound with a wide range of potential applications in the field of chemistry and biotechnology.

Upstream product

• 64-19-7 acetic acid 
• 156-87-6 propan-1-ol-3-amine 
• 110-19-0 2-methylpropyl acetate 
• 79-20-9 acetic acid methyl ester 
• 18312-45-3 propan-2-one O-acetyl oxime 
• 60759-49-1 N-acetyl-1,3-oxazol-2-one 
• 178244-37-6 N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide 
• 108-24-7 acetic anhydride 
• 108-22-5 Isopropenyl acetate 
• 141-78-6 ethyl acetate 
• 67-64-1 acetone 
• 108-05-4 vinyl acetate 

Downstream Products

• 133651-68-0 3-acetamidopropyl methacrylate 
• 118515-27-8 N-acetyl-2-methyltetrahydro-1,3-thiazine 
• 55943-46-9 (S)-2-Amino-3-(3,4-dihydroxy-phenyl)-2-methyl-propionic acid 3-acetylamino-propyl ester 

Relevant articles and documents

Synthesis of amide libraries with immobilized HOBt

Highly reactive N-acylating solid-phase reagents based on macroporous polystyrene-bound 1-hydroxybenzotriazole (P-HOBt) and silica-bound 1-hydroxybenzotriazole (Si-HOBt) were prepared and compared for reactivity by synthesis of small combinatorial libraries of acetamides and benzamides.

METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION

A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a spec

Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.