1074-55-1Relevant academic research and scientific papers
Chemoselective Deoxygenation of 2° Benzylic Alcohols through a Sequence of Formylation and B(C6F5)3-Catalyzed Reduction
Oestreich, Martin,Richter, Sven C.
, p. 2103 - 2106 (2021/07/22)
A sequence of formylation and B(C6F5)3-catalyzed reduction of the resulting formate with Et3SiH enables the chemoselective deoxygenation of secondary benzylic alcohols. Primary benzylic and tertiary non-benzylic alcohols are not reduced by this protocol. The formyl group fulfills a double role as activator and self-sacrificing protecting group. The deoxygenation of these formates is fast and can be carried out in the presence of other potentially reducible groups. Neighboring-group participation was found in the deoxygenation of certain diol motifs.
Room temperature iron catalyzed transfer hydrogenation usingn-butanol and poly(methylhydrosiloxane)
Coles, Nathan T.,Linford-Wood, Thomas G.,Webster, Ruth L.
supporting information, p. 2703 - 2709 (2021/04/21)
Reduction of carbon-carbon double bonds is reported using a three-coordinate iron(ii) β-diketiminate pre-catalyst. The reaction is believed to proceedviaa formal transfer hydrogenation using poly(methylhydrosiloxane), PMHS, as the hydride donor and a bio-alcohol as the proton source. The reaction proceeds well usingn-butanol and ethanol, withn-butanol being used for substrate scoping studies. Allyl arene substrates, styrenes and aliphatic substrates all undergo reduction at room temperature. Unfortunately, clean transfer of a deuterium atom usingd-alcohol does not take place, indicating a complex catalytic mechanism. However, changing the deuterium source tod-aniline gives close to complete regioselectivity for mono-deuteration of the terminal position of the double bond. Finally, we demonstrate that efficient dehydrocoupling of alcohol and PMHS can be undertaken using the same pre-catalyst, giving high yields of H2within 30 minutes at room temperature.
Cu3(BTC)2 metal organic framework as heterogeneous solid catalyst for the reduction of styrenes with silane as reducing agent
Anbu, Nagaraj,Dhakshinamoorthy, Amarajothi
, (2019/08/12)
In this work, a well known metal organic framework, Cu3(BTC)2 (BTC: 1,3,5-benzenetricarboxylate) is reported as a heterogeneous solid catalyst for the reduction of styrene and its derivatives with silane as a reducing agent. Under these reaction conditions, a quantitative conversion of styrene is achieved with very high selectivity to ethylbenzene. A control experiment with pyridine as a catalyst poison revealed that Cu2+ located within the framework plays a crucial role in promoting this reduction. Further, hot-filtration test indicated the absence of metal leaching and Cu3(BTC)2 is used four times with no significant decay in its activity. In addition, the four times used Cu3(BTC)2 was compared with the fresh solid by powder X-ray diffraction, FT-IR, UV–Visible diffuse reflectance spectra, scanning electron microscope and electron paramagnetic resonance methods and observing no significant changes in its structural integrity, crystallinity and morphology. This process is extended for other styrene derivatives to their respective reduced products.
Toward an Integrated Conversion of 5-Hydroxymethylfurfural and Ethylene for the Production of Renewable p-Xylene
Tao, Lei,Yan, Tian-Hao,Li, Wenqin,Zhao, Yi,Zhang, Qi,Liu, Yong-Mei,Wright, Mark M.,Li, Zhen-Hua,He, He-Yong,Cao, Yong
supporting information, p. 2212 - 2227 (2018/10/02)
The use of biomass as a solution to satisfy the pressing needs for a fully sustainable biocommodity industry has been explored for a long time. However, limited success has been obtained. In this study, a highly effective two-stage procedure for the direct preparation of para-xylene (PX) from 5-hydroxymethylfurfural (HMF) and formic acid in one pot is described; these chemicals are two of the major bio-based feedstocks that offer the potential to address urgent needs for the green, sustainable production of drop-in chemical entities. The use of a robust, efficient heterogeneous catalyst, namely, bimetallic Pd-decorated Au clusters anchored on tetragonal-phase zirconia, is crucial to the success of this strategy. This multifunctional catalytic system can not only facilitate a low-energy-barrier H2-free pathway for the rapid, nearly exclusive formation of 2,5-dimethylfuran (DMF) from HMF but also enable the subsequent ultraselective production of PX by the dehydrative aromatization of the resultant DMF with ethylene. With increasing pressure around the world to move toward a bio-based economy, it is essential that industrially important commodity chemicals can be readily accessed from biomass resources. Para-xylene (PX) synthesis is one such target that is being actively pursued through the development of several biorefinery schemes based on integrated biomass processing. Significant progress has recently been achieved either in the selective synthesis of biorenewable PX from Diels-Alder-like coupling of ethylene with 2,5-dimethylfuran (DMF) or making DMF from 5-hydroxymethylfurfural (HMF) using hydrogen as the terminal reductant. However, a green and direct conversion of HMF, an essential feedstock source for future biorefinery schemes, into PX has yet to be developed. We have established an integrated process that directly converts HMF to PX in a highly compact and hydrogen-independent manner, thereby providing a new perspective on the potential of advanced biorefinery technologies. Cao and colleagues describe an alternative strategy for producing para-xylene through a more sustainable method than the current bio-based approaches. The strategy relies on an integrated conversion of 5-hydroxymethylfurfural with formic acid and ethylene, made possible by the use of a single multifunctional catalyst based on bimetallic Pd-decorated Au deposited on tetragonal-phase zirconia. The proposed process is particularly appealing because it is fully fossil independent, implying a viable and greener biorefinery scheme.
Excellent Performances of Dealuminated H-Beta Zeolites from Organotemplate-Free Synthesis in Conversion of Biomass-derived 2,5-Dimethylfuran to Renewable p-Xylene
Zhao, Rongrong,Zhao, Zhenchao,Li, Shikun,Parvulescu, Andrei-Nicolae,Müller, Ulrich,Zhang, Weiping
, p. 3803 - 3811 (2018/10/24)
Direct synthesis of renewable p-xylene (PX) by cycloaddition of biomass-derived 2,5-dimethylfuran (2,5-DMF) and ethylene was achieved over Al-rich H-beta zeolites synthesized by an organotemplate-free approach and their dealuminated counterparts with different Si/Al ratios. Among them, H-beta zeolite with an Si/Al ratio of 22, obtained from an Al-rich parent by dealumination, was found to be an excellent catalyst for the synthesis of PX. A PX yield of 97 % and 2,5-DMF conversion of 99 % were obtained under optimized conditions. These results are even better than those of a commercial H-beta zeolite prepared using a organotemplate synthesis with a similar Si/Al ratio of 19. The excellent performance of the H-beta zeolite with Si/Al ratio of 22 is closely related to its acidity and porous structure. A moderate Br?nsted/Lewis acid ratio can improve the conversion of 2,5-DMF to as high as 99 %. Furthermore, dealuminated H-beta zeolite has a secondary pore system that facilitates product diffusion, which increases the selectivity to PX. In addition, this catalyst shows better regeneration. After five successive regeneration cycles, the yield of PX was still as high as 85 % without obvious dealumination. This work provides a deeper understanding of the more general Diels–Alder cycloaddition of furan-based feedstocks and olefins and significantly improves the potential for the synthesis of chemicals from lignocellulosic biomass.
Catalytic Synthesis of “Super” Linear Alkenyl Arenes Using an Easily Prepared Rh(I) Catalyst
Webster-Gardiner, Michael S.,Chen, Junqi,Vaughan, Benjamin A.,McKeown, Bradley A.,Schinski, William,Gunnoe, T. Brent
, p. 5474 - 5480 (2017/04/27)
Linear alkyl benzenes (LAB) are global chemicals that are produced by acid-catalyzed reactions that involve the formation of carbocationic intermediates. One outcome of the acid-based catalysis is that 1-phenylalkanes cannot be produced. Herein, it is reported that [Rh(μ-OAc)(η2-C2H4)2]2 catalyzes production of 1-phenyl substituted alkene products via oxidative arene vinylation. Since C C bonds can be used for many chemical transformations, the formation of unsaturated products provides a potential advantage over current processes that produce saturated alkyl arenes. Conditions that provide up to a 10:1 linear:branched ratio have been achieved, and catalytic turnovers >1470 have been demonstrated. In addition, electron-deficient and electron-rich substituted benzenes are successfully alkylated. The Rh catalysis provides ortho:meta:para selectivity that is opposite to traditional acid-based catalysis.
Iron-catalyzed olefin hydrogenation at 1 bar H2 with a FeCl3-LiAlH4 catalyst
Gieshoff, Tim N.,Villa, Matteo,Welther, Alice,Plois, Markus,Chakraborty, Uttam,Wolf, Robert,Jacobi Von Wangelin, Axel
supporting information, p. 1408 - 1413 (2015/03/18)
The scope and mechanism of a practical protocol for the iron-catalyzed hydrogenation of alkenes and alkynes at 1 bar H2 pressure were studied. The catalyst is formed from cheap chemicals (5 mol% FeCl3-LiAlH4, THF). A homogeneous mechanism operates at early stages of the reaction while active nanoparticles form upon ageing of the catalyst solution. This journal is
Role of sterically demanding chiral dirhodium catalysts in site-selective C-H functionalization of activated primary C-H bonds
Qin, Changming,Davies, Huw M. L.
, p. 9792 - 9796 (2014/07/22)
The influence of sterically demanding dirhodium tetracarboxylate catalysts on the site selectivity of C-H functionalization by means of rhodium carbene-induced C-H insertion is described. The established dirhodium tetraprolinate-catalyzed reactions of aryldiazoacetates cause preferential C-H functionalization of secondary C-H bonds as a result of competing steric and electronic effects. The sterically more demanding dirhodium tetrakis(triarylcyclopropanecarboxylate) catalysts, exemplified by dirhodium tetrakis[(R)-(1-(biphenyl)-2,2-diphenylcyclopropanecarboxylate)] [Rh 2(R-BPCP)4], favor C-H functionalization of activated primary C-H bonds. Highly site-selective and enantioselective C-H functionalization of a variety of simple substrates containing primary benzylic, allylic, and methoxy C-H bonds was achieved with this catalyst. The utility of this approach has been demonstrated by the late-stage primary C-H functionalization of (-)-∝-cedrene and a steroid.
Design and performance of supported Lewis acid catalysts derived from metal contaminated biomass for Friedel-Crafts alkylation and acylation
Losfeld, Guillaume,Escande, Vincent,Vidal De La Blache, Paul,L'Huillier, Laurent,Grison, Claude
experimental part, p. 111 - 116 (2012/09/08)
The main goal of this work was to prove the interest of metal hyperaccumulator plants in supported Lewis acid catalysis. Friedel-Crafts alkylation and acylation reveal the great catalytic activity of different plant extracts. This approach is a green solution with chemical benefits including high yield, excellent regioselectivity, small amounts of catalyst, mild conditions and concrete perspectives towards the depletion of mineral resources. The results also constitute an incentive for the development of phytoextraction programs on metal-bearing soils.
Microwave-assisted silica-supported aluminum chloride-catalyzed Friedel-Crafts alkylation
Zupp, Laurine R.,Campanella, Veronica L.,Rudzinski, Diandra M.,Beland, Franois,Priefer, Ronny
, p. 5343 - 5346 (2012/10/30)
Microwave irradiation is a popular method in organic synthesis to achieve high yields in shorter reaction times. This decreases total 'man-hours' in a synthetic setting. Another technique used in organic chemistry to decrease manual manipulations, is solid support reagents. The benefits of this approach is that upon completion of a reaction, a simple filtration can be performed which expedites the work-up and also produces less organic waste. Friedel-Crafts alkylation has been explored using microwave chemistry as well as with solid-supported reagents. In comparison with traditional heating, as well as with AlCl3, superior yields were observed with silica-gel bound aluminum chloride (Si-AlClx) when microwave irradiated for only 5 min.
