108644-84-4Relevant academic research and scientific papers
Synthesis of Trifluoromethyl-substituted Methanols: a Barbier Procedure under Pressure
Francese, Catherine,Tordeux, Marc,Wakselman, Claude
, p. 642 - 643 (1987)
Synthesis of trifluoromethyl methanols can be achieved by stirring a mixture of carbonyl compound, zinc powder, and pyridine under a slight pressure of trifluoromethyl bromide.
Trifluoromethylation and pentafluoroethylation of terpenoid carbonyl compounds used in perfumery
Watanabe, Shoji,Fujita, Tsutomu,Sakamoto, Masami,Mino, Yasuhiro,Kitazume, Tomoya
, p. 21 - 26 (1995)
The reaction of trifluoromethylsilane with a variety of terpenoid carbonyl compounds and other carbonyl compounds used in perfumery gave the corresponding trifluoromethylated derivatives.Pentafluoroethylated compounds were similarly obtained from the reac
Microreactors for the synthesis of fluorinated materials
Miyake, Noriaki,Kitazume, Tomoya
, p. 243 - 246 (2003)
The utility of microreactor for the synthesis of α-fluoro-α, β-unsaturated esters, trifluoromethylation and Michael addition reaction, is described.
Novel reductive olefination mediated by Ti(O-i-Pr)4 and Ph3P. One-pot synthesis of trifluoromethylated trans-allylic alcohols
Shen, Yanchang,Zhang, Yuming,Zhou, Yuefen
, p. 2195 - 2196 (1998)
A novel reductive olefination mediated by Ti(O-i-Pr)4 and Ph3P and its application to the 'one-pot' synthesis of perfluoroalkylated frans-allylic alcohols are described.
Enantioselective reduction of α,β-unsaturated ketones bearing the trifluoromethyl group
Nenajdenko, Valentine G.,Smolko, Konstantin I.,Balenkova, Elizabeth S.
, p. 1259 - 1266 (2001)
α,β-Unsaturated ketones bearing the trifluoromethyl group were enantioselectively reduced by a variety of reagents to the corresponding secondary allylic alcohols with e.e. in the range 87-99%. The influence of the trifluoromethyl group on the enantioselectivity is discussed.
Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones
Trost, Barry M.,Mata, Guillaume
, p. 12333 - 12337 (2018)
A nitrile-substituted trimethylenemethane (TMM) donor undergoes palladium-catalyzed [3+2] cycloadditions with fluorinated ketones to generate tetrasubstituted trifluoromethylated centers in high enantioselectivity under mild conditions. The generation of the palladium–TMM complex was achieved by a self-deprotonation strategy, which shows remarkable improvements in regiocontrol, efficiency, and atom economy of asymmetric [3+2] cycloadditions. Moreover, the versatility of the nitrile group provides direct access to a variety of synthetically useful intermediates, including amides, aldehydes, and esters. The developed reaction conditions allow for the synthesis of a wide variety of aromatic, heteroaromatic, and aliphatic fluorinated dihydrofurans in excellent regio- and enantioselectivities.
A facile stereocontrolled synthesis of anti-alpha-(trifluoromethyl)-beta-amino alcohols.
Prakash,Mandal,Schweizer,Petasis,Olah
, p. 3173 - 3176 (2000)
A short stereocontrolled preparation of anti-alpha-(trifluoromethyl)-beta-amino alcohols is described, involving an initial CF(3) transfer to cinnamaldehyde and a one-step, three-component condensation of 3,3,3-trifluorolactic aldehyde, an alkenyl (aryl)
Cesium fluoride catalyzed trifluoromethylation of esters, aldehydes, and ketones with (trifluoromethyl)trimethylsilane
Singh, Rajendra P.,Cao, Ganfeng,Kirchmeier, Robert L.,Shreeve, Jean'ne M.
, p. 2873 - 2876 (1999)
The low reactivity of carboxylic esters toward (trifluoromethyl)trimethylsilane (TMS-CF3) was investigated. A universal cesium fluoride catalyzed procedure for nucleophilic trifluoromethylation was developed. At room temperature (25 °C, with catalytic amounts of cesium fluoride, carboxylic esters were found to react to give the silyl ether intermediates, which afforded the trifluoromethyl ketones after hydrolysis. Sulfonic, sulfinic, and selenic esters also show good reactivity, giving novel trifluoromethylated compounds. The trifluoromethylation method was also applied to aldehydes and ketones, which were transformed to trifluoromethyl silyl ether intermediates and afforded trifluoromethylated alcohols in excellent yields after acid hydrolysis. Ethylene glycol dimethyl ether was used as solvent for solid or high boiling substrates, and benzonitrile was used for the low boiling substrates.
The interaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one with C-nucleophiles - organo-magnesium and -zinc compounds
Gorbunova, M. G.,Gerus, I. I.,Kukhar, V. P.
, p. 25 - 28 (1993)
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (1) reacts with phenylmagnesium bromide to give ethoxy group substitution products while the reaction of 1 with organozinc compounds gives products arising from 1,2-addition to the carbonyl group.Enone 1 reacts with electron-rich aromatic systems such as indole and N,N-dimethylaniline in the presence of a Lewis acid catalyst to give a β-arylvinyltrifluoromethylketone.
HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS
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Page/Page column 47, (2021/07/31)
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comp
