1154-63-8Relevant academic research and scientific papers
Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles
Zhang, Jin,Jia, Run-Ping,Wang, Dong-Hui
supporting information, p. 3604 - 3607 (2016/07/21)
A copper-catalyzed C–N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance.
Application of Fe3O4@SiO2@sulfamic acid magnetic nanoparticles as recyclable heterogeneous catalyst for the synthesis of imine and pyrazole derivatives in aqueous medium
Zakerinasab,Nasseri,Hassani,Samieadel
, p. 3169 - 3181 (2016/04/05)
Sulfamic acid supported on Fe3O4@SiO2 superpara magnetic nanoparticles was successfully applied as a recyclable solid acid catalyst with a large density of sulfamic acid groups for the synthesis of pyrazole derivatives, an important class of potentially bioactive compounds. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of toxic or expensive solvents and organic acids in this reaction.
Synthesis of [3,3′(4H,4′H)-Bi-2H-1,3-oxazine]-4,4′-diones and their hydrolysis
Korkusuz, Elif,Yildirim, Ismail
, p. 1339 - 1347 (2013/08/23)
The [3,3′(4H,4′H)-bi-2H-1,3-oxazine]-4,4′-diones 3a-3i were obtained by [2+4] cycloaddition reactions of furan-2,3-diones 1a-1c with aromatic aldazines 2a-2d (Scheme 1). So, new derivatives of bi-2H-1,3-oxazines and their hydrolysis products, 3,5-diaryl-1H-pyrazoles 4a-4c (Scheme 3), which are potential biologically active compounds, were synthesized for the first time. Copyright
PEG-SO3H as a mild, efficient and green catalytic system for the synthesis of pyrazole derivatives in aqueous medium
Nasseri,Alavi,Zakeri Nasab
, p. 213 - 219 (2013/07/26)
A versatile, alternative and environmentally benign strategy for the synthesis of a series of pyrazoles has been successfully performed in water using PEG-SO3H as an acidic catalyst. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of organic acids and toxic or expensive solvents in this reaction. The catalyst is waste-free, easily prepared, and efficiently re-used.
Facile one-pot synthesis of 3,5-disubstituted 1 h -pyrazoles from propargylic alcohols via propargyl hydrazides
Raji Reddy, Chada,Vijaykumar, Jonnalagadda,Grée, René
, p. 830 - 836 (2013/04/23)
A new and efficient metal-free, two-component, one-pot approach to a variety of 3,5-disubstituted 1H-pyrazoles has been developed from propargylic alcohols. This transformation proceeds via an acid-catalyzed propargylation of N,N-diprotected hydrazines followed by base-mediated 5-endo-dig cyclization leading to 3,5-disubstituted 1H-pyrazoles in good overall yields. Georg Thieme Verlag Stuttgart. New York.
Synthesis, characterization and fluorescence studies of 3,5-diaryl substituted 2-pyrazolines
Nee Pant, Geeta Joshi,Singh, Pramod,Rawat,Rawat,Joshi
, p. 1075 - 1079 (2011/04/16)
A series of 2-pyrazolines have been synthesized from α, β unsaturated ketones and hydrazine hydrate with acetic/formic acid in ethanol/DMSO. The structures of 2-pyrazolines have been established by spectroscopic techniques i.e. UV, IR, 1H NMR, 13C NMR and micro element analysis. Fluorescence spectra were recorded in the solution at fixed concentration and same excitation wavelength at 290 nm. The absorption band positions of all the compounds broadly lie between 280 and 336 nm and fluorescence band positions in the range between 300 and 370 nm, the near ultraviolet region.
Room temperature ICl-induced dehydration/iodination of 1-acyl-5-hydroxy-4, 5-dihydro-1H-pyrazoles. A selective route to substituted 1-acyl-4-iodo-1H- pyrazoles
Waldo, Jesse P.,Mehta, Saurabh,Larock, Richard C.
, p. 6666 - 6670 (2008/12/22)
(Chemical Equation Presented) A number of new functionally substituted 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles have been prepared in moderate to excellent yields from the corresponding 2-alkyn-1-ones. The resulting dihydropyrazoles undergo dehydration and iodination in the presence of ICl and Li2CO3 at room temperature to provide 1-acyl-4-iodo-1H- pyrazoles.
The preparation of N-acetylpyrazoles and their behavior toward alcohols
Kashima,Harada,Kita,Fukuchi,Hosomi
, p. 61 - 65 (2007/10/02)
According to four different methods, various types of n-acylpyrazoles were prepared from the corresponding pyrazoles and carboxylic acids or their acid chlorides. Although A-acylpyrazoles were inert to alcohols under neutral or weakly basic conditions, th
