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Methyl podophyllotoxinate is a semi-synthetic derivative of podophyllotoxin, a naturally occurring compound found in the roots and rhizomes of the mayapple plant (Podophyllum peltatum). It is primarily used as an active ingredient in topical medications for the treatment of external genital and perianal warts caused by human papillomavirus (HPV). Methyl podophyllotoxinate works by inhibiting the activity of tubulin, a protein involved in cell division, which leads to the disruption of the mitotic spindle and ultimately cell death. This targeted action helps to eliminate the infected cells without causing significant harm to the surrounding healthy tissue.

1643-12-5

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1643-12-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1643-12-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1643-12:
(6*1)+(5*6)+(4*4)+(3*3)+(2*1)+(1*2)=65
65 % 10 = 5
So 1643-12-5 is a valid CAS Registry Number.

1643-12-5Relevant academic research and scientific papers

Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

Suthiwong, Jittra,Wandee, Jaroon,Pitchuanchom, Siripit,Sojikul, Punchapat,Kukongviriyapan, Veerapol,Yenjai, Chavi

, p. 2042 - 2049 (2018/07/21)

Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.

Synthesis of (+/-)-4-Deoxypodophyllotoxin, (+/-)-Podophyllotoxin and (+/-)-Epipodophyllotoxin

Jones David W.,Thompson, Adrian M.

, p. 2541 - 2548 (2007/10/02)

6,7-Methylenedioxy-1-(3',4',5'-trimethoxyphenyl)-2-benzopyran-3-one 1 and dimethyl fumarate in acetonitrile give mostly the C-2 exo-CO2Me adduct 4 which is transformed in four steps into epipodophyllotoxin 10a.Attempted addition of dimethyl maleate to 1 p

Regioselective Suprafacial 1,5-Hydrogen Shifts in o-Quinodimethanes; a Route to 4-Deoxypodophyllotoxin

Jones, David W.,Thompson, Adrian M.

, p. 1095 - 1096 (2007/10/02)

The o-quinodimethane intermediate (4a) with cis-CO2Me groups undergoes regioselective 1,5-hydrogen shift to the cis-dihydronaphthalene (5a) whilst its trans-isomer (9a) gives both 1,5-hydrogen shift products (6a) and (7a); (5a) is readily converted into 4

A Stereo- and Regiocontrolled Synthesis of Podophyllum Lignans

Rodrigo, Russell

, p. 4538 - 4540 (2007/10/02)

A Diels-Alder adduct of an isobenzofuran (generated in situ) and dimethyl acetylenedicarboxylate is converted by a series of controlled reductions and isomerizations to the lignans deoxy- and isodeoxypodophyllotoxin in seven stages.

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