116783-28-9Relevant articles and documents
Triphenylphosphine-Tetrachloromethane Promoted Chlorination and Cyclodehydration of Simple Diols
Barry, Carey N.,Evans, Slayton A.
, p. 3361 - 3364 (1981)
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Enzymatic preparation of (1S,2R)- and (1R,2S)-stereoisomers of 2-halocycloalkanols
Kolodiazhna, Olga O.,Kolodiazhna, Anastasy O.,Kolodiazhnyi, Oleg I.
, p. 37 - 42 (2013/02/25)
The stereoisomers of cis-2-halocycloalkanols were resolved by a kinetically controlled transesterification with vinyl acetate in the presence of lipases in organic media. High enantioselectivities (ee >98%) and good isolated yields were obtained for all substrates using the appropriate lipase. Burkholderia cepacia lipase was the most efficient enzyme for the resolution of these substrates. The enantiomeric purities of the compounds were defined by derivatization with Mosher's acid and the absolute configurations were determined by chemical correlation.
Enantioselective synthesis of vicinal halohydrins via dynamic kinetic resolution
Ros, Abel,Magriz, Antonio,Dietrich, Hansjoerg,Fernandez, Rosario,Alvarez, Eleuterio,Lassaletta, Jose M.
, p. 127 - 130 (2007/10/03)
(Chemical Equation Presented) Expanding the scope of enantioselective catalysis via DKR, transfer hydrogenation of a variety of cyclic α-halo ketones was accomplished using the Noyori/Ikariya (R,R)- or (S,S)-I catalysts and either HCO2H/Et3N or HCO2Na/n-Bu 4NBr in H2O/CH2Cl2 as the hydrogen sources. Good yields of vicinal bromo-, chloro-, and fluorohydrins with excellent de and ee levels were achieved in most cases after a simple tuning of reaction conditions.
