117106-36-2

Usage

InChI:InChI=1/C16H20N2O2/c1-19-13-7-3-11(4-8-13)15(17)16(18)12-5-9-14(20-2)10-6-12/h3-10,15-16H,17-18H2,1-2H3/t15-,16+

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 58546-78-4 C₃₀H₂₈N₂O₄ 
• 64-17-5 ethanol 
• 3717-21-3 p-methoxyl benzaldoxime 
• 41097-47-6 N,N'-Bis-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 58519-97-4 meso-N,N'-bis(4-methoxybenzylidene)-1,2-bis(4-methoxyphenyl)ethylenediamine 
• 132127-28-7 N-trimethylsilyl-(4-methoxybenzaldimine) 
• 58519-97-4 (1R,2S)-1,2-Bis-(4-methoxy-phenyl)-N,N'-bis-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-ethane-1,2-diamine 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 58520-45-9 (1R,2S)/(1S,2R)-1,2-diamino-1,2-bis(4-methoxyphenyl)ethane 
• 51208-43-6 meso-1,2-bis-(p-methoxyphenyl)-ethylenediamine 
• 162407-08-1 2,3-Bis-(4-methoxy-phenyl)-1,4-diaza-spiro[4.5]deca-1,3-diene 
• 45821-44-1 4-methoxy-benzylideneamine 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 

Downstream Products

• 1413934-30-1 2,2,2-trichloroethyl((1R,2R)-2-benzamido-1,2-bis(4-methoxyphenyl)ethyl)carbamate 
• 1413934-40-3 bis(2,2,2-trichloroethyl)((1R,2R)-1,2-bis(4-methoxyphenyl)ethane-1,2-diyl)dicarbamate 
• 1599484-91-9 C₃₈H₄₂N₄O₈S₂ 
• 1619263-28-3 C₅₇H₅₄N₆O₆ 
• 1436431-43-4 C₆₆H₆₈N₂O₁₀ 
• 1429397-53-4 C₂₃H₂₄N₂O₆S 
• 1429397-54-5 C₂₃H₂₀Br₄N₂O₆S 

Relevant academic research and scientific papers

Syntheses of Families of Enantiopure and Diastereopure Cobalt Catalysts Derived from Trications of the Formula [Co(NH2CHArCHArNH2)3]3+

Aerobic reactions of CoX2 (X = OAc, Cl) or Co(ClO4)2 with (S,S)-1,2-diphenylethylenediamine [(S,S)-dpen] in CH3OH, followed by HCl or HClO4 additions, give the diastereomeric lipophobic salts Λ-[Co((S

Ultrasound accelerated reductive coupling of imine or iminium ion generated in 5m lithium perchlorate solution by lithium metal

A novel one-pot reductive coupling of imine or iminium ion generated in the concentrated ethereal lithium perchlorate solution was achieved in the presence of lithium metal. The yield of the reaction depends on the reactivity preformed imine or iminium ion. Diamines were formed with high diastereoselectivity in some cases in about 5 h. The reaction time was doubled without the use of ultrasound acceleration.

Reaction of aromatic aldehydes with ammonium acetate

By reaction of aromatic aldehydes with ammonium acetate a series of 1,2-diaryl-1,2-diamino-ethanes and their derivatives was obtained. The mechanism of reaction was suggested and its principal stages were proved. Reactions with ammonium acetate of aromatic aldehydes containing ortho-substituents resulted in the corresponding 2,4,5-triaryl-4,5-dihydroimidazoles.

Highly diastereoselective and enantioselective addition of organometallic reagents to a chiral C2-symmetrical bisimine

An efficient and straightforward method has been developed for the preparation of enantiomerically enriched C2-symmetrical vicinal diamines via the addition of organometallic reagents to a chiral bisimine, which gives access to a variety of optically pure aromatic and aliphatic C 2-symmetrical vicinal diamines in high yields. The 'Cram-Davis' open transition state model is proposed to rationalize the observed stereoselectivities for the addition of organolithium reagents to the bisimine. Georg Thieme Verlag Stuttgart.

Diboron glycol ester as well as preparation method, intermediate and application thereof

The invention discloses diboron glycol ester as well as a preparation method, an intermediate and application thereof. The diboron glycol ester can be used for inducing reductive coupling reaction with imine as a substrate, and the substrate can be obtained by reaction of aldehyde and ammonia and is very easy to obtain and quite low in cost. The product can be separated from a reaction system onlyby acid-base operation without column chromatography purification, and the post-treatment mode is convenient and easy to operate. The yield of the obtained product is high, and protective group operation is not needed. The diboron glycol ester has chirality, the stereoselectivity of the reductive coupling reaction is generally excellent, and 99% ee chiral diamine can be obtained only through simple recrystallization. The diboron glycol ester can be obtained by reacting diol with diboron glycol ester, the diol is convenient to prepare and easy to amplify, the diol can be recycled from a reaction solution through simple acid-base operation, the recovery rate reaches 95%, and the preparation cost is further saved.

Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron

We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method signifies the generality of diboron-enabled [3,3]-sigmatropic rearrangement.

Method for preparing intermediate of chiral vicinal diamine

The invention discloses a method for preparing an intermediate of chiral vicinal diamine. The method comprises the following steps: adding a compound IV into a solvent, stirring the compound IV and the solvent in an ice water bath, adding an initiator into the obtained reaction system, adding a reducing agent into the reaction system in batches, heating the reaction system to 20-80 DEG C, and stirring the reaction system; and extracting the reaction system after the reaction is completed, drying the obtained organic phase, filtering the dried organic phase, and performing rotary drying to obtain a compound V that is the intermediate. The preparation method of the invention has the advantages of simplicity and mild reaction conditions, and can be widely applied to industrial production.

Chemoselective Photoredox Synthesis of Unprotected Primary Amines Using Ammonia

Unprotected α-amino carbon radicals are produced as novel intermediates via a transformation that merges acid-promoted N-H imine generation and chemoselective photocatalytic single-electron reduction. Coupling ammonia and aldehydes/ketones allows the generation of primary amines under mild conditions without the need for protecting groups. The key intermediate can be efficiently transformed into primary (di)amines by a formal dimerization, reductive amination via hydrogen atom transfer, and arylation through radical-radical coupling.

TRANSITION METAL COMPLEXES FOR ENANTIOSELECTIVE CATALYSIS OF CARBON-CARBON, CARBON-HETEROATOM, AND CARBON-HYDROGEN BOND FORMING REACTIONS

In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula Φ-[Μ (x,y)-L1 (w,v)-L2 (t,u)-L3]p+An-mZ-p_m. In an embodiment of the present disclosure Φ may be A. In another embodiment Φ may be Δ. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L1, L2, and L3 independently is a ligand comprising a substituted diamine. In some embodiments, An" comprises a lipophilic anion, where m is from 1 to 3, and where Z- comprises an optional second anion.

NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST

The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantioselectivity, etc.; a catalyst which comprises the ruthenium complex; and a process for producing optically active compound, in particular, an optically active alcohol compound, using the catalyst. The ruthenium complex has a ruthenacyclic structure. The catalyst is a catalyst for asymmetric reduction which comprises the ruthenium complex.