118627-04-6

Basic information

• Product Name: (+/-)-podophyllotoxin
• CAS NO: 118627-04-6
• Molecular Weight: 414.412
• Mol File: 118627-04-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (+/-)-podophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-podophyllotoxin(118627-04-6)
• EPA Substance Registry System: (+/-)-podophyllotoxin(118627-04-6)

Safety Data

• Hazardous Substances Data: 118627-04-6(Hazardous Substances Data)

Upstream product

• 116097-18-8 6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)-2-benzopyran-3-one 
• 104715-48-2 (5S,6S,7S,8R)-7-Aminomethyl-8-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 13311-04-1 9r-(Tetrahydro-<2>pyranyloxy)-5c-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydro-8H-furo<3',4':6,7>naphtho<2,3-d>(1,3)-dioxol-6-on 
• 75101-87-0 dimethyl 1,4-epoxy-1,2,3,4-tetrahydro-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-2,3-cis-naphthalenedicarboxylate 
• 76886-74-3 C₂₄H₂₂O₁₀ 
• 74879-25-7 -3,4-methylenedioxybenzaldehyde dimethyl acetal 
• 74879-22-4 6-bromobenzo-1,3-dioxole-5-carboxaldehyde dimethyl acetal 
• 120-57-0 piperonal 
• 86301-75-9 dimethyl 4-(3,4-trans)-hydroxy-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-cis-dicarboxylate 
• 1256-91-3 methyl isopicropodophyllate 
• 75101-87-0 dimethyl 1,4-epoxy-1,2,3,4-tetrahydro-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-2,3-trans-naphthalenedicarboxylate 
• 75101-88-1 methyl 1,4-epoxy-3-exo-(hydroxymethyl)-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2-endo-carboxylate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 108763-81-1 3-(2',2'-di-t.butyl-r-4'-(3,4-methylenedioxyphenyl)-2'-sila-1',3'-dioxane-c-5'-yl)-propane-1,2-diol 

Downstream Products

• 59123-24-9 (±)-β-apopicropodophyllin 
• 477-51-0 deoxypicropodophyllotoxin 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-L-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-D-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-L-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-D-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 
• 112246-50-1 1-O-(β-L-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 112246-48-7 (5S,5aS,8aS,9R)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 112246-49-8 1-O-(β-L-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 
• 112317-52-9 1-O-(2-amino-2-deoxy-β-L-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 112318-79-3 1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 112246-51-2 1-O-(2-amino-2-deoxy-β-L-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 
• 92206-82-1 Chloro-acetic acid 4-((5S,5aS,9R)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester 
• 112146-51-7 C₄₁H₄₁Cl₂NO₁₆ 

Relevant articles and documents

A Mild Method for Selective Cleavage of Tetrahydropyranyl Ethers in the Presence of Other Acid-Labile Functionalities

A mild method for selective cleavage of tetrahydropyranyl ethers in the presence of other acid sensitive functionalities such as acetonides, methoxymethyl ethers, methylenedioxy ethers, mesitylaldehyde acetals and t-butyldimethylsilyl ethers using Lewis acid-thiol system is described.

A concise stereocontrolled formal total synthesis of (+/-)-podophyllotoxin using sulfoxide chemistry.

A short stereoselective formal total synthesis of (+/-)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picrop

Synthesis of Podophyllum Lignans via an Isolable o-Quinonoid Pyrone

The 2-benzopyran-3-one 10 is a stable, isolable and useful Diels-Alder diene; its methyl 4-benzoyloxycrotonate adduct 23 formed regioselectively and stereoselectively in acetonitrile is reduced with H2/Pd to give 31 with inversion of C-1 stereochemistry.T