120-65-0

Basic information

• Product Name: 2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL)
• Synonyms: 2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL);2-[(dimethylamino)methyl]-pheno;alpha-dimethylamino-o-cresol;o-(Dimethylaminomethyl) phenol;α-Dimethylamino-o-cresol;2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL) 70+%;(contains Phenol);2-DiMethylaMinoMethylphenol
• CAS NO: 120-65-0
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• EINECS: 204-413-9
• Mol File: 120-65-0.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 216.7°C at 760 mmHg
• Flash Point: 85.4°C
• Appearance: /
• Density: 1.02
• Vapor Pressure: 0.094mmHg at 25°C
• Refractive Index: 1.5300-1.5340
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL)(120-65-0)
• EPA Substance Registry System: 2-DIMETHYLAMINOMETHYLPHENOL (CONTAINS PHENOL)(120-65-0)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 1760
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 120-65-0(Hazardous Substances Data)

Usage

Uses

2-(Dimethylaminomethyl)phenol, can be used in the preparation of ortho-aminomethylphenols and their derivatives, possessing antibacterial and antifungal activity.

InChI:InChI=1/C9H13NO/c1-10(2)7-8-5-3-4-6-9(8)11/h3-6,11H,7H2,1-2H3

Upstream product

• 123-91-1 1,4-dioxane 
• 139-02-6 sodium phenoxide 
• 30438-74-5 N-(chloromethyl)dimethylamine 
• 58774-83-7 [(2-methoxyphenyl)methyl]dimethylamine 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 108-95-2 phenol 
• 51-80-9 bis-(dimethylamino)methane 
• 1122-85-6 phenyl cyanate 
• 33797-51-2 eschenmoser's salt 
• 201230-82-2 carbon monoxide 
• 932-30-9 2-Hydroxybenzylamine 
• 131471-25-5 N,N-dimethyl-2-(prop-2'-enyloxy)benzylamine 
• 90-02-8 salicylaldehyde 

Downstream Products

• 195374-47-1 benzoic acid-(2-dimethylaminomethyl-phenyl ester) 
• 77104-67-7 dimethyl-carbamic acid-(2-dimethylaminomethyl-phenyl ester) 
• 102666-48-8 phenyl-thiophosphonic acid O,O'-bis-(2-dimethylaminomethyl-phenyl ester) 
• 40247-97-0 2-(1-methyl-1,3,4,10a-tetrahydro-2H,5H-chromeno[2,3-b]pyridin-4a-ylmethyl)-phenol 
• 91252-77-6 Dimethyl-(2-methansulfonyloxy-phenylmethyl)-amin 
• 112251-64-6 Ethyl-(2-hydroxy-benzyl)-dimethyl-ammonium; bromide 
• 78013-54-4 Ethyl-(2-hydroxy-benzyl)-dimethyl-ammonium; iodide 
• 78013-56-6 (2-Hydroxy-benzyl)-dimethyl-propyl-ammonium; iodide 
• 26753-12-8 o-dimethylaminomethylphenol methylammonium iodide 
• 100-02-7 4-nitro-phenol 
• 129379-65-3 Bis-chloromethyl-phosphinic acid 2-dimethylaminomethyl-phenyl ester 
• 86796-86-3 2-Dimethylaminomethyl-phenol anion 
• 780766-37-2 [2-(4-bromo-2-nitrophenoxy)benzyl]dimethylamine 
• 68995-66-4 (C₄H₉)3SnOC₆H₄CH₂N(CH₃)2 

Relevant articles and documents

Triethylsiloxymethyl-N,N-dimethylamine, Et3SiOCH2NMe2: A Dimethylaminomethylation (Mannich) Reagent for O–H, S–H, P–H and Aromatic C–H Systems

Triethylsiloxymethylamine, Et3SiOCH2NMe2, readily synthesized in high yield by the hydrosilylation reaction between Et3SiH and DMF, is an excellent (N,N-dimethylamino)methyl transfer agent to a representative range of aliphatic alcohols, thiols, and Ph2PH (E–H) materials. The reactions are almost instantaneous at room temperature in inert solvents and require no activating agents to produce E–CH2NMe2 products in high yields and illustrate the title compound as an excellent addition to the family of organic reagents. For aromatic alcohols, electrophilic substitution of the aromatic ring occurs in high yield. Crystal structures of new materials such as the cholestero–CH2NMe2 derivative, 2–4-[bis(N,N-dimethylamino)methyl]-1-naphthol, and the phosphine oxide derived from Ph2PCH2NMe2 are reported.

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A modified Mannich-Type reaction catalyzed by VO(acac)2

(Equation Presented) A fackile VO(acac)2-catalyzed in situ generation of iminium ions from amine N-oxides and their participation in a modified Mannich-type reaction is described.

Photo-Induced ortho-C-H Borylation of Arenes through in Situ Generation of Rhodium(II) Ate Complexes

Photoinduced in situ "oxidation"of half-sandwich metal complexes to "high-valent"cationic metal complexes has been used to accelerate catalytic reactions. Here, we report the unprecedented photoinduced in situ "reduction"of half-sandwich metal [Rh(III)] complexes to "low-valent"anionic metal [Rh(II)] ate complexes, which facilitate ligand exchange with electron-deficient elements (diboron). This strategy was realized by using a functionalized cyclopentadienyl (CpA3) Rh(III) catalyst we developed, which enabled the basic group-directed room temperature ortho-C-H borylation of arenes.

Anti-tumor application of tocopheroxyl nitrogen oxide as HDAC (Histone Deacetylase) inhibitor

The invention discloses anti-tumor application of tocopheroxyl nitrogen oxide as an HDAC (Histone Deacetylase) inhibitor. A compound has a structural general formula as shown in a formula (I), and the compound has a potential inhibition effect on HDAC, so that more nitrogen and oxygen can be further provided for a ZBG (Zinc Binding Group), multi-length survey and the like can be carried out on a linker, structure modification can be carried out on the existing basis, and the functions of an inhibitor having good selectivity on HDAC subtype and other target points are expected to be found. According to the anti-tumor application disclosed by the invention, synthetic raw materials are relatively cheap, the technology is simple, the purity is higher, the cost is lower, and used reagents are all relatively safe. The compound is expected to be used as a novel HDAC inhibitor type anti-tumor medicine which is strong in selectivity, high in efficiency and low in toxicity.