120106-66-3

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 1820-42-4 bis(4-chlorophenyl)acetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 501-65-5 diphenyl acetylene 
• 104-55-2 3-phenyl-propenal 
• 109-92-2 ethyl vinyl ether 
• 766-84-7 3-chloro-benzonitrile 
• 873-32-5 2-Chlorobenzonitrile 
• 100-42-5 styrene 
• 40739-81-9 (E)-4-methyl-N'-(4-methylbenzylidene)benzenesulfonohydrazide 
• 3510-48-3 4-chlorobenzaldehyde azine 
• 19277-54-4 p-chlorophenyldiazomethane 

Downstream Products

• 1132647-59-6 C₂₅H₂₄Cl₂N₄O 
• 1132647-57-4 C₂₁H₂₀Cl₂N₄O 
• 1228505-61-0 C₂₂H₁₆Cl₂N₄O₂ 

Relevant academic research and scientific papers

Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles

Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.

Transition Metal, Azide, and Oxidant-Free Homo- and Heterocoupling of Ambiphilic Tosylhydrazones to the Regioselective Triazoles and Pyrazoles

With N-tosylhydrazone as an ambiphilic reagent, an unprecedented cyclization reaction of two identical or different tosylhydrazones has been developed to access various 4,5-disubstituted-2H-triazoles under transition metal, azide, and oxidant-free conditi

1, 2, 3-TRIAZOLE DERIVATIVES AS NEW CANNABINOID-1 RECEPTOR ANTAGONISTS

The present invention relates to 1,2,3-triazole derivatives which can be used as cannabinoid CB1 receptor antagonists. In addition, the compound of the 1,2,3-triazole derivatives in the present invention can be formulated into a pharmaceutical composition

1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists

This letter reports the new entry of novel 1,2,3-triazole derivatives as CB1 receptor antagonists. The design, synthesis and biological evaluation of N1 and N2 substituted 1,2,3-trizoles are described. The N2 substituted, symmetrical 1,2,3-triazoles are m

THE REACTIONS OF HYDRAZONES AND RELATED COMPOUNDS WITH STRONG BASES. PART 4. 4,5-DIARYL-1,2,3-TRIAZOLES FROM AROMATIC ALDEHYDE AZINES AND FROM THE REACTION OF ARENECARBONITRILES WITH ARYLDIAZOMETHANES

Reaction of aromatic aldehyde azines in dimethyl sulphoxide at 20 deg C with potassium t-butoxide gave 4,5-diaryl-1,2,3-triazoles (4) and stilbenes.Mechanisms were studied by addition of possible intermediates and by (14)C tracer methods.The synthesis of 4,5-diaryl-1,2,3-triazoles from arenecarbonitriles, aryldiazomethanes, and potassium t-butoxide in toluene is described and the mechanism is discussed.