1201808-31-2Relevant articles and documents
Influence of the side-chain structure and molecular weight on the re-entrant behaviors of mesogen-jacketed liquid crystalline polymers
Xiang, Zheng,Chen, Sheng,Luo, Yongbing,Li, Ping,Zhang, Hailiang
, p. 78516 - 78527 (2016)
Three series of mesogen-jacketed liquid crystalline polymers (MJLCPs) containing different terminal groups (phenmethyl, diphenylmethyl and triphenylmethyl) in the side chains, abbreviated as Pv-m-Bn, Pv-m-DPM, Pv-m-Tr (m = 2, 4, 6, 8, 10, and 12, which are the number of methylene units between the terephthalate core and terminal groups in the side chains), were designed and successfully synthesized via free-radical polymerization. Molecular characterization of the polymers was performed by 1H NMR, GPC and TG analysis. The phase structures and transitions of the polymers were investigated by a combination of techniques including DSC, POM and 1D/2D WAXD. The experimental results revealed that all the polymers exhibited excellent thermal stabilities and the re-entrant behaviors of the MJLCPs were found to be strongly dependent on the structure of the side-chain, i.e., the spacer length increased with the volume of the terminal groups when the polymers exhibited the re-entrant isotropic phase. On the other hand, a series of MJLCPs, poly{2,5-bis[(diphenylmethoxy-ethyl)oxycarbonyl]-styrenes} (Pv-2-DPMs), with different molecular weights (Mn) and narrow Mn distributions have been successfully synthesized via ATRP. The results indicated that when the Mn was below 1.73 × 104 g mol-1, only the isotropic phase was observed. When Mn was between 3.40 × 104 g mol-1 and 8.48 × 104 g mol-1, a re-entrant isotropic phase was formed at low temperatures and a columnar nematic phase at high temperatures. By further increasing the Mn to exceed 9.71 × 104 g mol-1, a stable columnar nematic phase was developed. This work provides two effective ways to design and synthesize MJLCPs with re-entrant behaviors; moreover, it is meaningful to deeply understand the structure-property relationships of MJLCPs.
Reductive cleavage of acetals/ketals with ZrCl4/NaBH4
Purushothama Chary,Santosh Laxmi,Iyengar
, p. 1257 - 1261 (1999)
Reductive cleavage of acetals/ketals with zirconium tetrachloride- sodium borohydride leading to the formation of ether alcohols is described.
Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition
Madak, Joseph T.,Cuthbertson, Christine R.,Chen, Wenmin,Showalter, Hollis D.,Neamati, Nouri
, p. 13875 - 13878 (2017)
Brequinar, a potent dihydroorotate dehydrogenase (DHODH) inhibitor, has been evaluated in multiple clinical trials as a potential treatment for cancer. To further understand brequinar-based DHODH inhibition and DHODH′s therapeutic relevance in cancer, we
New facts concerning the reaction of K-, K+(15-crown-5)2 with phenyl glycidyl ether: Unexpected formation of potassium cyclopropoxide
Grobelny, Zbigniew,Stolarzewicz, Andrzej,Maercker, Adalbert,Demuth, Wolfgang
, p. 153 - 157 (1999)
A new mechanism of the reaction of K-, K+(15-crown-5)2 with phenyl glycidyl ether is presented. The linear ether bond is attacked only to a small extent, if at all. As the main reaction path the oxirane bond in the β-posit
Unexpected Cleavage of Crown Ether in the Reaction of Methyloxirane with K-,K+(15-crown-5)2
Grobelny, Zbigniew,Stolarzewicz, Andrzej,Czaja, Monika,Demuth, Wolfgang,Maercker, Adalbert
, p. 8990 - 8994 (1999)
Cleavage of oxirane and crown ether rings occurs when the supramolecular complex K-,K+(15-crown-5)2 reacts with methyloxirane in tetrahydrofuran solution. Potassium isopropoxide and potassium tetraethylene glycoxide vinyl
Fe2O3-Promoted Intermolecular Chlorotrifluoromethylthiolation of Alkenes
Jia, Yimin,Qin, Hongmei,Wang, Na,Jiang, Zhong-Xing,Yang, Zhigang
, p. 2808 - 2817 (2018)
A simple, convenient method for intermolecular chlorotrifluoromethylthiolation of alkenes by using a low-cost and more abundant iron catalyst has been developed. This protocol provides a straightforward way to synthesize a variety of useful SCF3/sub
A molecular Fe-complex as a catalyst probe for in-gel visual detection of proteins via signal amplification
Kumari, Sushma,Panda, Chakadola,Mazumdar, Shyamalava,Sen Gupta, Sayam
, p. 15257 - 15260 (2015)
We report the use of a molecular peroxidase mimic biuret-Fe-TAML for chemoselective labeling of proteins and the subsequent visual detection (0.1 pmoles) of the conjugate in a polyacrylamide gel by catalytic signal amplification. Use of this probe in act
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Suthagar, Kajitha,Watson, Andrew J.A.,Wilkinson, Brendan L.,Fairbanks, Antony J.
, p. 153 - 166 (2015)
Abstract A series of arabinose glycosyl sulfamides with varying alkyl chain types and lengths were synthesised as mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Unprecedented conversion of
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Eliel,Badding
, p. 6087 (1959)
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Is macrocycle a synonym for kinetic inertness in Gd(III) complexes? Effect of coordinating and noncoordinating substituents on inertness and relaxivity of Gd(III) chelates with DO3A-like ligands
Polasek, Miloslav,Caravan, Peter
, p. 4084 - 4096 (2013)
Gadolinium chelates with octadentate ligands are widely used as contrast agents for magnetic resonance imaging (MRI), with macrocyclic ligands based on DO3A being preferred for the high kinetic inertness of their Gd chelates. A major challenge in the design of new bifunctional MRI probes is the need to control the rotational motion of the chelate, which greatly affects its relaxivity. In this work we explored facile alkylation of a secondary amine in macrocyclic DO3A-like ligands to create a short, achiral linkage to limit the undesired internal motion of chelates within larger molecular constructs. The acetate moiety on the trans nitrogen was also replaced with either a bidentate (ethoxyacetate, L1 or methyl picolinate, L2) or bulky monodentate (methyl phosphonate, L3) donor arm to give octa- or heptadentate ligands, respectively. The resultant Gd(III) complexes were all monohydrated (q = 1) and exhibited water residency times that spanned 2 orders of magnitude (τM = 2190 ± 170, 3500 ± 90, and 12.7 ± 3.8 ns at 37 C for GdL1, GdL2, and GdL3, respectively). Alkylation of the secondary amine with a noncoordinating biphenyl moiety resulted in coordinatively saturated q = 0 complexes of octadentate ligands L1 and L2. Relaxivities were limited by slow water exchange and/or lack of water coligand. All complexes showed decreased inertness compared to [Gd(DO3A)] despite higher ligand denticity, and inertness was further decreased upon N-alkylation. These results demonstrate that high kinetic inertness and in vivo safety of Gd chelates with macrocyclic ligands should not be generalized.
A novel way for hydroxyethylation by using clay catalysts
Sallay, Peter,Bekassy, Sandor,Ahmed, Mohamed H.,Farkas, Laszlo,Rusznak, Istvan
, p. 661 - 664 (1997)
Hydroxyethylation of aralkyl alcohols (benzyl alcohol, 2-phenylethanol, 3-phenylpropanol) in the presence of a clay catalyst (K10) was successful. This method has some advantages in contrast with the conventional ones: effective, works at mild reaction conditions, ease the separation of catalyst from the reaction mixture.
Synthesis of β-damascone from 2,6-dimethylcyclohexanone
Chaumont-Olive, Pauline,Plevová, Kristína,Collado Pérez, Ana María,Sánchez-Quesada, Jorge,?ebesta, Radovan,Cossy, Janine
supporting information, p. 140 - 150 (2022/02/10)
The synthesis of β-damascone can be achieved from 2,6-dimethylcyclohexanone using a Rupe rearrangement or a Barton vinyl iodation as the key steps.
4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads
Ahlert, Heinz,Bhatia, Sanil,Borkhardt, Arndt,Breit, Bernhard,Gunther, Stefan,Hansen, Finn K.,Hugle, Martin,Kraft, Fabian B.,Mishra, Pankaj,Schaker-Hubner, Linda,Schliehe-Diecks, Julian,Scholer, Andrea,Warstat, Robin
, p. 14620 - 14646 (2021/10/20)
Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biological evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Additionally, 61 was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds.
Composition for controlling pine wood nematode containing benzyloxyalcohol
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Paragraph 0055-0056, (2021/06/15)
The present invention relates to a composition for controlling pine nematode comprising a benzyloxyalcohol compound and a method for controlling pine nematode using the same.
