Synthesis of Podophyllotoxin

DOI: 10.1039/c39890001370

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1370 - 1371 (1989)

Update date:2022-09-26

Topics:

Authors:

Jones, David W.

Thompson, Adrian M.

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Article abstract of DOI:10.1039/c39890001370

The alkene (2) obtained directly from the reaction of dimethyl maleate with the pyrone (1) is converted into (+/-)-podophyllotoxin (12) in seven steps and 24percent overall yield; novel steps include the epimerisation of (9) at C-3 using 1,8-diazabicyclo<

Full text of DOI:10.1039/c39890001370

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