128-03-0Relevant articles and documents
Synthesis and antifungal activity of new carbamodithioic acid esters derived from 3-acetylcoumarin
Guersoy,Ates,Karali,Cesur,Kiraz
, p. 643 - 646 (1996)
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Synthesis characterization and biological evaluation of 2-methyl-3-(N-substituted thiocarbamoylthio)acetamido-4(3H)-quinazolinones
Capan,Ergenc,Buyuktimkin,Yulug
, p. 243 - 250 (2007/10/02)
Reaction of 3-chloroacetamido-2-methyl-4(3H)-quinazolinones (1 and 2) with appropriately substituted potassium dithiocarbamates (3) furnished 2-methyl-3-(N-substituted thiocarbamoylthio)acetamido-4(3H)-quinazolinones (4 and 5) which exist as isomeric mixtures. The structures of 4 and 5 were determined by analytical and spectral (IR, 1H-NMR, EIMS, CIMS(CH4 or NH3)) methods. All the compounds except for 4g and 5g were tested for antimicrobial activity against some bacteria und fungi. Only 4b and 4c were found active against Staphylococcus aureus (MIC 100 μg/ml). 4d, 4e, 4g, 4h, 5a-f and 5h were also evaluated for anticonvulsant activity but were found inactive.