Chemical Communications p. 1323 - 1326 (2018)
Update date:2022-07-29
Topics:
Zhao, Jianxiong
Lichman, Benjamin R.
Ward, John M.
Hailes, Helen C.
Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to generate THIAs in high yields.
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