133902-65-5Relevant articles and documents
An efficient solid-phase synthesis of substituted isoxazole, triazole, and cycloalkadiene derivatives using supported selenium resin
Wang, Yu-Guang,Xu, Wei-Ming,Huang, Xian
, p. 28 - 32 (2007)
We have developed efficient methods for the syntheses of 3,5-disubstituted isoxazoles and 1,2,3-triazoles, and 1,3- and 1,4-cycloalkadiene derivatives using polymer-supported selenium resin. The advantages of these methods include straightforward operation, lack of odor, good stability, and high purity of the products. Georg Thieme Verlag Stuttgart.
Alkyl Propiolates Participated [3+2] Annulation for the Switchable Synthesis of 1,5- and 1,4-Disubstituted 1,2,3-Triazoles Containing Ester Side Chain
Cao, Shuo,Liu, Yunyun,Hu, Changfeng,Wen, Chengping,Wan, Jie-Ping
, p. 5021 - 5025 (2018/10/15)
By means of a featured enamine activation, the alkyl propiolates have been successfully employed in the [3+2] annulation for the synthesis of 1,2,3-triazoles. The synthesis of both 1,4- as well as the hardly available 1,5-disubstituted 1,2,3-triazoles can be selectively accessed by using tosyl azide and tosyl hydrazine as nitrogen source, respectively.
Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors
Huang, Qiang,Zheng, Maofa,Yang, Shuangshuang,Kuang, Chunxiang,Yu, Cunjing,Yang, Qing
scheme or table, p. 5680 - 5687 (2011/12/16)
Previously, we have reported the design and synthesis of 4-aryl-1H-1,2,3-triazoles as inhibitors of indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target of cancer. Here, we present the structure-activity relationship and enzyme kinetic studie