13841-96-8

Basic information

• Product Name: diamminediiodoplatinum
• Synonyms: diammine-diiodoplatin;Einecs 237-562-3;Platinous diiododiammine;Platinum, diamminediiodo-
• CAS NO: 13841-96-8
• Molecular Formula: H₆I₂N₂Pt
• Molecular Weight: 482.941
• EINECS: 237-562-3
• Product Categories: Miscellaneous Reagents
• Mol File: 13841-96-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: diamminediiodoplatinum(CAS DataBase Reference)
• NIST Chemistry Reference: diamminediiodoplatinum(13841-96-8)
• EPA Substance Registry System: diamminediiodoplatinum(13841-96-8)

Safety Data

• Hazardous Substances Data: 13841-96-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Coordination compound.

Upstream product

• 7664-41-7 ammonia 
• 33634-55-8 cis-Pt(meNH₂)2I₂ 
• 10025-99-7 potassium tetrachloroplatinate(II) 
• 1336-21-6 ammonium hydroxide 
• 7681-11-0 potassium iodide 
• 14708-49-7 tetrammineplatinum(II) iodide 
• 67143-70-8 {Pta₂aesCl}Cl 
• 26035-31-4 transplatin 

Downstream Products

• 142159-62-4 diamine platinum sulfate 
• 74006-35-2 {Pta₂(NO₃)2} 
• 13601-02-0 H₁₀N₂O₂Pt⁽²⁺⁾*2NO₃^(1-) 
• 41575-94-4 carboplatinum 
• 14708-49-7 tetrammineplatinum(II) iodide 
• 7664-41-7 ammonia 
• 7440-06-4 platinum 
• 16893-05-3 trans-diamminetetrachloroplatinum(IV) 
• 6894-20-8 trans-bis(phenylamino)diiodoplatinum(II) 
• 41575-87-5 trans-dinitrato-diammine-platinum(II) 

Relevant articles and documents

Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme

The reactivity of cis-diamminediiodidoplatinum(II), cis-PtI 2(NH3)2, the iodo analogue of cisplatin, with hen egg white lysozyme (HEWL) was investigated by electrospray ionization mass spectrometry and X-ray crystallography. Interestingly, the study compound forms a stable 1:1 protein adduct for which the crystal structure was solved at 1.99 A resolution. In this adduct, the PtII center, upon release of one ammonia ligand, selectively coordinates to the imidazole of His15. Both iodide ligands remain bound to platinum, with this being a highly peculiar and unexpected feature. Notably, two equivalent modes of PtII binding are possible that differ only in the location of I atoms with respect to ND1 of His15. The structure of the adduct was compared with that of HEWL-cisplatin, previously described; differences are stressed and their important mechanistic implications discussed.

A method for the treatment of tumor cell proliferative diseases of platinum (II) compound

Disclosed are a platinum compound with the leaving group malonic derivative "2" position substituent containing a primary amino, a secondary amino, a tertiary amino, and a quaternary amino, as well as pharmaceutically acceptable salt, preparation method thereof, and pharmaceutical composition containing the compound. Also disclosed are uses of the compound for treating cell proliferative diseases, particularly cancers. The platinum compound of the present invention has the high water solubility and the low toxicity.

Synthesis, characterization, structures and cytotoxicity of platinum(II) complexes containing dimethylpyrazole based selenium ligands

A series of water soluble platinum(II) complexes of general formulae [Pt(en)(L)][NO3]2, [Pt(NH3)2(L)][NO3]2 [en = ethylenediamine; L = dmpzC6H4Se(CH2)nCOOH or dmpzCH2CH2Se(CH2)nCOOH (n = 1 and 2)], [Pt(en)(L)][NO3][OH]·H2O [L = dmpzCH2CH2Se(CH2)nCOOH (n = 1 and 2)] and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O have been synthesized. They were characterized by microanalyses, IR, NMR (1H, 13C{1H}, 77Se{1H} and 195Pt{1H}) spectroscopy. Molecular structures of [Pt(en)(dmpzCH2CH2SeCH2COOH)][NO3][OH]·H2O and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O were determined unambiguously by single crystal X-ray diffraction analyses. The cytotoxicity of these complexes has been evaluated against human colon (HT29, Colo205), ovarian (A2780) and bladder (T24) cancer cell lines and compared with the activity of cisplatin and adriamycin.