1437-57-6

Basic information

• Product Name: N,5-Diphenyl-1,3,4-thiadiazol-2-amine
• Synonyms: N,5-Diphenyl-1,3,4-thiadiazol-2-amine
• CAS NO: 1437-57-6
• Molecular Formula: C₁₄H₁₁N₃S
• Molecular Weight: 253.32224
• Mol File: 1437-57-6.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,5-Diphenyl-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,5-Diphenyl-1,3,4-thiadiazol-2-amine(1437-57-6)
• EPA Substance Registry System: N,5-Diphenyl-1,3,4-thiadiazol-2-amine(1437-57-6)

Safety Data

• Hazardous Substances Data: 1437-57-6(Hazardous Substances Data)

Upstream product

• 13153-01-0 1-benzoyl-4-phenyl-3-thiosemicarbazide 
• 13373-11-0 2-chloro-5-phenyl-[1,3,4]thiadiazole 
• 62-53-3 aniline 
• 100-52-7 benzaldehyde 
• 103-72-0 phenyl isothiocyanate 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 1172-02-7 9-dicyanomethylene-2,4,7-trinitrofluorene 
• 13456-63-8 1-benzylidene-4-phenylthiosemicarbazide 
• 670-54-2 ethenetetracarbonitrile 
• 93-58-3 benzoic acid methyl ester 
• 65-85-0 benzoic acid 
• 1119010-84-2 2-cyanoethyl phenylcarbamodithioate 
• 613-94-5 benzoic acid hydrazide 
• 18039-42-4 5-Phenyl-1H-tetrazole 

Downstream Products

• 63586-61-8 N-phenyl-N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-acetamide 
• 63586-59-4 N-phenyl-N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-toluene-4-sulfonamide 
• 63586-57-2 5-phenyl-2-phenylimino-3-(toluene-4-sulfonyl)-2,3-dihydro-[1,3,4]thiadiazole 

Relevant articles and documents

Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C-S bond formation in thiosemicarbazones

An effective oxidative intramolecular cyclization (C-S bond formation) of thiosemicarbazones using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) has been developed to afford a diverse array of 2-amino-substituted-1,3,4-thiadiazoles. The attractive featu

An efficient one-pot procedure for the preparation of 1,3,4-thiadiazoles in ionic liquid [Bmim]BF4 as dual solvent and catalyst

The one-pot three component condensation of hydrazine hydrate with substituted phenylisothiocyanates followed by the addition of substituted benzaldehydes in the presence of ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4)

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Synthesis of some 1,3,4-thiadiazole derivatives as inhibitors of Entamoeba histolytica

In the quest for potent anti-amoebic agents, some 1,3,4-thiadiazole derivatives were synthesized and characterized by spectral data. The purity of the compounds was confirmed by elemental analysis. All the compounds were screened in vitro against HM1:IMSS strain of Entamoeba histolytica by microdilution method. The results revealed that compounds 1 (IC50 = 0.670 μM), 3 (IC50 = 1.60 μM) and 8 (IC50 = 0.522 μM) had much better anti-amoebic activity than the reference drug metronidazole (IC50 = 1.80 μM). Further, cytotoxicity of the compounds having IC50 value less than metronidazole was assessed by MTT assay on human breast cancer MCF-7 cell line and all the compounds were found low cytotoxic in the concentration range of 2.5-250 μM. Preliminary results indicate that these three compounds (1, 3 and 8) may be subjected to further investigations and it may be hoped that the present study will stimulate efforts towards the development of novel effective anti-amoebic agents.