14770-96-8

Basic information

• Product Name: (2-HYDROXY-5-METHOXYPHENYL)(PHENYL)METHANONE
• Synonyms: (2-HYDROXY-5-METHOXYPHENYL)(PHENYL)METHANONE
• CAS NO: 14770-96-8
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24
• Mol File: 14770-96-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 84–85°C5
• Boiling Point: 374.8°C at 760 mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 3.77E-06mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: (2-HYDROXY-5-METHOXYPHENYL)(PHENYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXY-5-METHOXYPHENYL)(PHENYL)METHANONE(14770-96-8)
• EPA Substance Registry System: (2-HYDROXY-5-METHOXYPHENYL)(PHENYL)METHANONE(14770-96-8)

Safety Data

• Hazardous Substances Data: 14770-96-8(Hazardous Substances Data)

Usage

Preparation

Preparation by Friedel–Crafts acylation of hydroquinone dimethyl ether with benzoyl chloride in the presence of aluminium chloride, in carbon disulfide first at 25° for 48 h, then at 50° for 30 min (55%) or at r.t. for 48 h (by-product).

InChI:InChI=1/C14H12O3/c1-17-11-7-8-13(15)12(9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3

Upstream product

• 4038-13-5 2,5-dimethoxybenzophenone 
• 98-88-4 benzoyl chloride 
• 150-78-7 1,4-dimethoxybezene 
• 1523-19-9 4-methoxyphenyl benzoate 
• 141883-76-3 [2-(Cyclohex-2-enyloxy)-5-methoxy-phenyl]-phenyl-methanone 
• 7446-70-0 aluminium trichloride 
• 108-86-1 bromobenzene 
• 2612-02-4 5-methoxysalicylic acid 
• 618-32-6 Benzoyl bromide 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 98-80-6 phenylboronic acid 
• 41951-80-8 2-(hydroxy(phenyl)methyl)-4-methoxyphenol 
• 100-52-7 benzaldehyde 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 2050-37-5 2,5-dihydroxybenzophenone 
• 4038-13-5 2,5-dimethoxybenzophenone 
• 41951-80-8 2-(hydroxy(phenyl)methyl)-4-methoxyphenol 
• 936716-84-6 C₂₃H₂₂O₃ 
• 1279130-96-9 (E)-4-methoxy-2-(phenyl((3,4,5-trimethoxyphenyl)imino)methyl)phenol 
• 1279131-19-9 (S)-4-methoxy-2-(phenyl((3,4,5-trimethoxyphenyl)amino)methyl)phenol 
• 93655-47-1 3-acetyl-6-methoxy-4-phenyl-2H-chromen-2-one 
• 1374987-96-8 4-(2-benzoyl-4-methoxyphenoxy)but-2-enoic acid methyl ester 
• 1334335-06-6 2-(imino(phenyl)methyl)-4-methoxyphenol 
• 1334247-38-9 (S)-2-(amino(phenyl)methyl)-4-methoxyphenol 
• 40547-03-3 6-Methoxy-4-phenyl-2H-1-benzopyran-2-one 
• 1202186-04-6 1-(2-hydroxy-5-methoxyphenyl)-1-phenyl-4-methyl-4-(tetrahydropyran-2-yloxy)-pent-2-yn-1-ol 

Relevant articles and documents

Aryl Mesylates in Metal-Catalyzed Homocoupling and Cross-Coupling Reactions. 3. A Simple and General Method for the Synthesis of 2,2'-Diaroyl-4,4'-dihydroxybiphenyls

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Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Photo-Fries rearrangement in flow under aqueous micellar conditions

A flow edition of photo-Fries rearrangement for the synthesis of 2-acylphenols in an aqueous micellar medium has been described. We take advantage of a narrow channel reactor and micelle-induced confinement effect to refine both the efficiency and selectivity of the parent photoreaction. This journal is