1518-86-1

Usage

Uses

Used in Ophthalmology:
Hydroxyamphetamine is used as a mydriatic agent for diagnostic eye examinations and surgical procedures on the eye. Its primary application is to dilate the pupil, facilitating a clearer view of the eye's interior structures and ensuring a smoother surgical process.
Used in Combination Therapy:
Hydroxyamphetamine is sometimes used in combination with cholinergic blocking drugs like atropine to produce a more pronounced mydriatic effect. This combination therapy enhances the dilation of the pupil, providing a better examination or surgical field compared to using either drug alone.

Veterinary Drugs and Treatments

Hydroxyamphetamine is an indirectly acting sympathomimetic which is used to diagnose Cranial Nerve III denervation syndromes such as Horner’s Syndrome. Hydroxyamphetamine stimulates release of norepinephrine from postganglionic neurons and therefore amplifies pupil dilation response in hypersensitive, denerved neurons.

InChI:InChI=1/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3

Upstream product

• 64-13-1 2-amino-1-(4-methyoxyphenyl)propane 
• 57736-33-1 (+/-)-4-(2-amino-propyl)-aniline 
• 658-48-0 2-amino-3-(4-hydroxy-phenyl)-2-methyl-propionic acid 
• 60-15-1 2-amino-1-phenylpropane 
• 3240-42-4 p-Hydroxy-norephedrin-HCl 
• 27566-05-8 4-(2-(benzylamino)propyl)phenol 
• 770-39-8 4-methoxyphenylacetone 
• 56935-39-8 α-methyl-β-(p-methoxyphenyl)-propionyl chloride 
• 39755-38-9 3-(4'-methoxyphenyl)-2-methyl-propanamide 
• 37629-51-9 1-methoxy-4-((E)-2-nitroprop-1-enyl)benzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 7176-38-7 1-(4-Benzyloxyphenyl)-2-nitro-1-propen 
• 7176-39-8 2-(4-benzyloxy-phenyl)-1-methyl-ethylamine 

Downstream Products

• 103153-58-8 4-[2-(1-methyl-2-phenyl-ethylamino)-propyl]-phenol 
• 60677-79-4 (2,6-Dichloro-4-{1-hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-carbamic acid ethyl ester 
• 62401-66-5 p-Hydroxy-fenetyllin 
• 3673-98-1 rac. 2-(4-Hydroxy-phenyl)-1-methyl-2'-phenoxy-diaethylamin 
• 27566-05-8 4-(2-(benzylamino)propyl)phenol 
• 1241224-85-0 C₁₉H₂₅N₃O₂ 
• 1241565-96-7 C₁₈H₃₀N₂O₂ 
• 1281135-71-4 1-[2-(4-hydroxy-phenyl)-1-methyl-ethyl]-3-(2-thiophen-2-yl-ethyl)-urea 

Relevant academic research and scientific papers

Iterative Alanine Scanning Mutagenesis Confers Aromatic Ketone Specificity and Activity of L-Amine Dehydrogenases

Direct reductive amination of prochiral ketones catalyzed by amine dehydrogenases is attractive in the synthesis of active pharmaceutical ingredients. Here, we report the protein engineering of L-Bacillus cereus amine dehydrogenase to allow reactivity on synthetically useful aromatic ketone substrates using an iterative, multiple-site alanine scanning mutagenesis approach. Mutagenesis libraries based on molecular docking, iterative alanine scanning, and double-proximity filter approach significantly expand the scope of active pharmaceutical ingredients relevant building blocks. The eventual quintuple mutant (A115G/T136A/L42A/V296A/V293A) showed reactivity toward aromatic ketones 12 a (5-phenyl-pentan-2-one) and 13 a (6-phenyl-hexan-2-one), which have not been reported to serve as targets of reductive amination by currently available amine dehydrogenases. Docking simulation and tunnel analysis provided valuable insights into the source of the acquired specificity and activity.

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

Improved synthetic method of (R)-1-aryl-2-propylamine

The invention provides an improved synthetic method of (R)-1-aryl-2-propylamine. The improved synthetic method comprises the following steps of: adopting 1-arylacetone as a raw material, adding (R)-1-phenylethylamine, carrying out reductive amination reaction with hydrogen under a common action of a Lewis acid additive and a transitional metal hydrogenation catalyst; carrying out Pd/C catalytic hydrogenation on an obtained intermediate to remove phenethyl on nitrogen and thus obtaining (R)-1-aryl-2-propylamine. The improved synthetic method provided by the invention has the beneficial effectsthat the operation is simple, the adopted Lewis acid additive is low in cost and easy in obtaining, the yield and the enantioselectivity of a product are high, and the application value for industrialsynthesis of (R)-1-aryl-2-propylamine is very high.

A Bioinspired Synthesis of Polyfunctional Indoles

Polyfunctional indoles bearing substituents at C5 and C6 are prevalent in natural products, pharmaceuticals, agrochemicals, and materials. Owing to the remoteness of the C5 and C6 positions, indoles of this family can be difficult to prepare, and often require multistep syntheses. Herein, we describe a concise process that converts simple derivatives of tyrosine into 5,6-difunctionalized indoles by direct oxidation of C?H, N?H, and O?H bonds. Our work draws inspiration from the biosynthetic polymerization of tyrosine to make melanin pigments, but makes an important departure to provide well-defined indole heterocycles.

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS

The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

AZETIDINE DERIVATIVES

Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used. The Royal Society of Chemistry 2011.

DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE BETA2 ADRENERGIC RECEPTOR

The present invention provides a compound of formula (I): wherein: ? R1 is a group selected from -CH2OH,-NH(CO)H and ? R2 is a hydrogen atom; or ? R1together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1and the carbon atom is bound to the carbon atom in the phenyl ring holding R2 ? R3a and R3bare independently selected from the group consisting of hydrogen atoms and C1-4alkyl groups, ? n represents an integer from 1 to 3; ? Ad represents 1-adamantyl or 2-adamantyl group, or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.

Magnesium-Catalyzed Proficient Reduction of Oximes to Amines Using Ammonium Formate

Various aldoximes and ketoximes were selectively reduced to the corresponding amines by catalytic transfer hydrogenation employing low cost magnesium powder and ammonium formate at room temperature. Many other functionalities such as halogens, -OH, -OCH3, -COOH and -CH 3 remained unaffected. The hydrogenation is fast, mild, clean, cost effective and high yielding.