15183-74-1

Basic information

• Product Name: 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE
• Synonyms: 4-(1,1,1-TRIFLUOROMETHANESULFONYL)ANISOLE;4-(1,1,1-TRIFLUOROMETHANSULFONYL)-ANISOLE;1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE;4-(trifluoromethylsulfonyl)anisole
• CAS NO: 15183-74-1
• Molecular Formula: C₈H₇F₃O₃S
• Molecular Weight: 240.2
• Mol File: 15183-74-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE(15183-74-1)
• EPA Substance Registry System: 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE(15183-74-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 15183-74-1(Hazardous Substances Data)

Upstream product

• 887144-94-7 Togni's reagent II 
• 6462-50-6 sodium 4-methoxybenzenesulfinate 
• 66107-29-7 4-methoxyphenyl triflate 
• 2926-29-6 Langlois reagent 
• 623-12-1 4-chloromethoxybenzene 
• 104-94-9 4-methoxy-aniline 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 1961266-44-3 2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate 
• 368-91-2 4-methoxybenzene-1-sulfonyl fluoride 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 141339-54-0 bis(4-anisyl)iodonium triflate 
• 1330681-27-0 (4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate 
• 1310070-02-0 (4-methoxyphenyl)(4-nitrophenyl)iodonium p-toluenesulfonate 

Downstream Products

• 46403-72-9 4-methoxy-3-nitro-benzenesulfonic acid 
• 50579-45-8 4-Butyloxy-3-nitro-benzolsulfonsaeure 
• 135722-63-3 4’-methoxy-N,N-diphenyl-[1,1’-biphenyl]-4-amine 
• 27331-33-5 1-(4-methoxyphenyl)naphthalene 
• 53040-92-9 4-(4-tolyl)anisole 
• 194222-69-0 (2,6-Dinitro-4-trifluoromethanesulfonyl-phenyl)-trifluoromethanesulfonyl-acetic acid ethyl ester 
• 19822-34-5 2,6-dinitro-4-trifluoromethylsulfonylchlorobenzene 
• 19822-29-8 2,6-dinitro-4-((trifluoromethyl)sulfonyl)anisole 
• 360-00-9 2-nitro-4-((trifluoromethyl)sulfonyl)anisole 
• 613-37-6 4-methoxylbiphenyl 
• 140-67-0 Estragole 
• 609-66-5 2-chlorobenzamide 
• 150-76-5 4-methoxy-phenol 

Relevant articles and documents

Cu-catalyzed couplings of aryl iodonium salts with sodium trifluoromethanesulfinate

A convenient method for the preparation of aryl trifluoromethylsulfones from the reactions of diaryliodonium salts with sodium trifluoromethanesulfinate in the presence of copper catalysts is described. Cuprous oxide in DMF was found to be the optimal catalyst for the reaction. The reaction conditions are tolerant of various functional groups as well as of various counteranions of the iodonium salt. The synthetic utility of the process is demonstrated by performing the reaction on a preparative scale (88 g).

Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto's reagent II

A practical and efficient method for the synthesis of aryl trifluoromethyl sulfones has been developed by a tandem reaction of arylsulfonyl chlorides with Umemoto's reagent II. The advantageous features of this method are simple operation, mild reaction conditions, wide scope of substrates, high yield of products, and easy scalability.

Cross-Coupling of Aryl Trifluoromethyl Sulfones with Arylboronates by Cooperative Palladium/Rhodium Catalysis

The Suzuki-Miyaura arylation of aryl trifluoromethyl sulfones via C-SO2 bond cleavage has been developed by means of cooperative palladium/rhodium catalysis. A series of aryl trifluoromethyl sulfones and arylboronic acid neopentylglycol esters are converted to the corresponding biaryls. Mechanistic investigations suggest that (1) the rhodium catalyst mediates the transfer of the aryl ring from arylboronate to palladium, resulting in the acceleration of the transmetalation step, and (2) the C-C bond-forming reductive elimination step is the turnover-limiting step.