156086-03-2

Basic information

• Product Name: Benzothiazole, 5,6-dimethoxy-2-phenyl-
• CAS NO: 156086-03-2
• Molecular Formula: C15H13NO2S
• Molecular Weight: 271.34
• Mol File: 156086-03-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzothiazole, 5,6-dimethoxy-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 5,6-dimethoxy-2-phenyl-(156086-03-2)
• EPA Substance Registry System: Benzothiazole, 5,6-dimethoxy-2-phenyl-(156086-03-2)

Safety Data

• Hazardous Substances Data: 156086-03-2(Hazardous Substances Data)

Upstream product

• 860521-22-8 1-benzoylamino-2-benzoylmercapto-4,5-dimethoxy-benzene 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 804476-57-1 N-(2,4,5-trimethoxyphenyl)benzamide 
• 26510-91-8 2,4,5-trimethoxyaniline 
• 103-82-2 phenylacetic acid 
• 6315-89-5 3,4-dimethoxyaniline 
• 100-46-9 benzylamine 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 
• 100601-30-7 2-amino-4,5-dimethoxy-thiophenol 
• 804476-56-0 N-(2,4,5-trimethoxyphenyl)thiobenzamide 
• 58249-73-3 bis-(4,5-dimethoxy-2-nitro-phenyl)-disulfane 
• 51072-66-3 1-bromo-4,5-dimethoxy-2-nitro-benzene 

Downstream Products

• 855281-01-5 2-phenyl-benzothiazole-5,6-diol 

Relevant articles and documents

NH4I-promoted oxidative formation of benzothiazoles and thiazoles from arylacetic acids and phenylalanines with elemental sulfur

A NH4I/K3PO4-based catalytic system has been established to enable oxidative formation of thiazole compounds from arylacetic acids and phenylalanines with elemental sulfur. While the three-component reaction of anilines or β-naphthylamines with arylacetic acids and elemental sulfur affords benzo[2,1-d]thiazoles and naphtho[2,1-d]thiazoles, the annulation of phenylalanines with elemental sulfur produces 2-benzyl and 2-benzoylthiazoles. This work well complements previous three-component annulations of benzothiazoles from other coupling partners.

Copper-Catalyzed Aerobic Oxidation of Amines to Benzothiazoles via Cross Coupling of Amines and Arene Thiolation Sequence

A one-pot three-component synthesis of benzothiazoles has been developed using the copper-catalyzed aerobic cross coupling of amines followed by arene thiolation using elemental sulfur. The dual roles of elemental sulfur and CuCl(OH)-TMEDA in the aerobic amine oxidation and the aniline thiolation enable the facile access to benzothiazole derivatives from readily available starting materials. The operational simplicity of the current promiscuous catalyst system suggests the high synthetic potential in the preparation of heterocyclic compounds. (Figure presented.).

Assembly of 2-Arylbenzothiazoles through Three-Component Oxidative Annulation under Transition-Metal-Free Conditions

Highly efficient methods for the synthesis of 2-arylbenzothiazoles and 2-arylnaphtho[2,1-d]thiazoles have been developed. Readily available aromatic amines, benzaldehydes, and elemental sulfur were directly assembled through oxidative annulation and C-H f