1575-94-6Relevant academic research and scientific papers
A simple and one-pot multi-component reaction to the synthesis of methylenebisamides
Mohammadi, Bagher,Khorrami, Bahareh Rezaei
, p. 1089 - 1092 (2018)
Abstract: This work described a simple and efficient method for the synthesis of some methylenebisamide derivatives. The reaction is carried out via a simple multi-component reaction between arylaldehydes, DMSO, and hydroxylamine hydrochloride. Short reaction times, excellent yields of products, inexpensive and readily available starting material, eco-friendly method, easy work-up, and high atom economy are the main advantages of this reaction.
DMSO-Mediated Synthesis of Methylene-Bridged Unsymmetrical Bisamides in the Presence of AcOH
Chen, Jing,Ma, Yongmin,Zhang, Yi,Zhou, Dongheng
, p. 297 - 303 (2019/12/28)
A simple and efficient procedure for the synthesis of N -[(methylthio)methyl]benzamides and methylene-bridged unsymmetrical bisamides was achieved mediated by DMSO in the presence of acetic acid. DMSO plays a dual role in the transformation, as not only a solvent, but also an environmentally benign methylene source. The protocol provides new strategies for effective synthesis of unsymmetrical bisamides and avoids the use of transition-metal catalysts.
One-Pot Anodic Conversion of Symmetrical Bisamides of Ethylene Diamine to Unsymmetrical gem-Bisamides of Methylene Diamine
Golub, Tatiana,Dou, Gui-Yuan,Zeng, Cheng-Chu,Becker, James Y.
, p. 7961 - 7964 (2019/10/11)
Symmetrical bisamides of ethylene diamine of type ArCONHCH2CH2NHCOAr undergo anodic C-C bond cleavage in acetonitrile-LiClO4 under controlled-potential electrolysis. The electrogenerated carbocation intermediates react with the solvent acetonitrile to afford unsymmetrical gem-bisamides of type ArCONHCH2NHCOMe in a one-pot reaction. The yields of the latter products are moderate (up to 60%). Other minor products involve two symmetrical gem-bisamides of type ArCONHCH2NHCOAr and MeCONHCH2NHCOMe and fragmentation products (e.g., ArCONHCHO, ArCONH2, and ArCN).
Selectfluor-mediated oxidative methylenation of amide with N, N -dimethylpropanamide for N, N ′-methylenebisamide synthesis
Cao, Yue,Zhou, Dongheng,Ma, Yongmin
, p. 37 - 41 (2019/01/10)
A simple and efficient approach for the synthesis of N,N′-methylenebisamides through a Selectfluor-mediated oxidative reaction of aromatic amides and N,N-dimethylpropanamide (DMP) is described. Remarkable results clearly reveal that DMP plays a dual role in this reaction, as both a one-carbon source and an environment-friendly solvent. Moreover, the process provides new strategies for the synthesis of bisamides with advantages of operationally simple, insensitive to atmospheric conditions, and good to high yields.
Cobalt(III)-Catalyzed and Dimethyl Sulfoxide-Involved Cross-Coupling of Ketones and Amides for Direct Synthesis of β-Amino Ketones
Xu, Xuefeng,Zhou, Zhi,Wang, Zhipin,Ma, Xinna,Chen, Xin,Zhang, Xu,Yu, Xiyong,Yi, Wei
supporting information, p. 4278 - 4285 (2019/08/12)
A straightforward synthesis of β-amino ketones has been realized by employing ketones and amides as the substrates via cobalt(III)-catalyzed and dimethyl sulfoxide-involved cross-coupling reaction. Experimental investigations revealed that the β-methylsul
Three-component synthesis of amidomethylarenes and -heteroarenes over HΒ zeolite under solvent-free conditions
Chevella, Durgaiah,Mameda, Naresh,Kodumuri, Srujana,Banothu, Rammurthy,Gajula, Krishna Sai,Kutepov, Boris Ivanovich,Nama, Narender
, p. 20 - 25 (2017/11/20)
A highly efficient and eco-friendly protocol has been described for the synthesis of amidomethylarenes and -heteroarenes via one-pot three-component coupling reaction of amides, aldehydes and (hetero)arenes over a heterogeneous catalyst (Hβ zeolite) in solvent-free conditions. The scope and limitations of this catalytic process are demonstrated with various amides and arenes and the corresponding amidoalkylated arene products were obtained in moderate to excellent yields. The preliminary mechanistic insight (control experiments) suggest that bisamide and/or N-(hydroxymethyl)benzamide are probable intermediates in this reaction. Moreover, the catalyst can be reused without any significant loss of the catalytic activity and only water is produced as by-product.
A nano silver-xerogel (Ag nps@modified TEOS) as a newly developed nanocatalyst in the synthesis of benzopyranopyrimidines (with secondary and primary amines) and: Gem -bisamides
Kour, Gurpreet,Gupta, Monika
, p. 7039 - 7050 (2017/07/10)
Silver nanoparticles have been prepared from a chemical reduction approach and supported on modified TEOS (tetraethylorthosilicate) xerogels to be studied as a nanocatalyst in the conversions of benzopyranopyrimidines (with primary as well as secondary am
N, N - methylene-bis-benzamides synthetic method of the compound
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Paragraph 0025; 0026; 0027; 0028; 0029-0031; 0032; 0033, (2017/08/24)
The invention belongs to the technical field of organic synthesis and discloses a synthesis method of N,N-methylene-bis-benzamide compounds. The synthesis method includes the following steps: dissolving a benzamide compound in a solvent; adding elementary
One pot preparations N,N′-alkylidene bisamide derivatives catalyzed by Nano-TiCL4.SiO2 with antimicrobial studies of some products
Khabnadideh, Soghra,Zomorodian, Kamiar,Mirjalili, Bi Bi Fatemeh,Izadi, Elham,Zamani, Leila
, p. 3034 - 3038 (2016/11/17)
Nano-TiCl4.SiO2 has been introduced to be an extremely efficient catalyst for the preparation of N,N′-alkylidene bisamides from various aldehydes and amides under mild conditions. We synthesized this solid Lewis acid catalyst by the
A methylene-bis-amide derivatives method for the preparation of
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Paragraph 0021; 0022; 0023, (2016/10/09)
The invention belongs to the technical field of bisamide organic compounds and discloses a methylenebisamide derivative and a preparation method thereof. The structural formula of the methylenebisamide derivative is shown in the specification. The preparation method comprises the following steps: with benzamide and N, N-dimethylacetamide as reactants, putting the reactants in a reactor, adding water, sodium persulfate and ceric ammonium nitrate and carrying out reaction for 12h at the temperature of 110 DEG C in the air atmosphere to obtain the methylenebisamide compound. According to the preparation method disclosed by the invention, with water as a solvent, the preparation method is environmentally friendly and green; the synthetic method is simple in operation, efficient in reaction, high in reaction selectivity, small in amount of by-products and suitable for industrial production and has the yield generally being 43-86 percent.
