1643-97-6

Basic information

• Product Name: 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene
• Synonyms: 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene;(4-Methylphenyl)(4-fluorophenyl) sulfone;1-Fluoro-4-[(4-methylphenyl)sulfonyl]benzene;1-Fluoro-4-tosylbenzene;4-Fluorophenyl p-tolyl sulfone;p-Fluorophenyl p-tolyl sulfone;p-Tolyl 4-fluorophenyl sulfone;1-(4-fluorophenyl)sulfonyl-4-methylbenzene
• CAS NO: 1643-97-6
• Molecular Formula: C₁₃H₁₁FO₂S
• Molecular Weight: 250.2886432
• EINECS: 216-702-7
• Mol File: 1643-97-6.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 382.8°Cat760mmHg
• Flash Point: 185.3°C
• Appearance: /
• Density: 1.262g/cm³
• Vapor Pressure: 1.02E-05mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene(1643-97-6)
• EPA Substance Registry System: 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene(1643-97-6)

Safety Data

• Hazardous Substances Data: 1643-97-6(Hazardous Substances Data)

Usage

General Description

1-Fluoro-4-[(4-methylphenyl)sulphonyl]benzene is a chemical compound with the molecular formula C13H11FO2S. It is a fluorinated benzene derivative with a sulfonyl group attached to a methylphenyl ring. 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene is known for its application as a building block in the synthesis of pharmaceuticals and agrochemicals, particularly in the development of novel sulfonyl-based drugs. It is also used in the production of specialty chemicals and advanced materials. Additionally, 1-fluoro-4-[(4-methylphenyl)sulphonyl]benzene is used as a reagent in organic synthesis and as a precursor for the creation of various functionalized molecules in chemical research. Due to its versatile properties and applications, this chemical has garnered significant interest in the scientific and industrial communities.

InChI:InChI=1/C13H11FO2S/c1-10-2-6-12(7-3-10)17(15,16)13-8-4-11(14)5-9-13/h2-9H,1H3

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 96783-59-4 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)diazene 
• 462-06-6 fluorobenzene 
• 153170-80-0 N-fluoro-4-methyl-N-tosylbenzenesulfonamide 
• 371-40-4 4-fluoroaniline 
• 437-29-6 tris(4-fluorophenyl)bismuthane 
• 5720-05-8 4-methylphenylboronic acid 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 106-38-7 para-bromotoluene 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 915763-50-7 C₁₃H₁₀ClFO₄S₂ 

Relevant articles and documents

Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones

A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is

Sulfonylation of Bismuth Reagents with Sulfinates or SO2through BiIII/BiV Intermediates

Studies to explore the catalytic activities of main-group elements are attractive. We report here our study of sulfonylation of bismuth reagents with sulfinates or SO2 surrogates. Under oxidative conditions, triarylbismuthines and sulfinates were transformed into diaryl sulfones. A transition-metal-like two-electron redox process at the Bi center was achieved in this reaction. Sulfur dioxide generated in situ can also replace sulfinates to deliver the corresponding symmetric diaryl sulfones. A rational mechanism for this reaction was also proposed that involves a Bi(III)-Bi(V) manifold.

An efficient heterogeneous copper fluorapatite (CuFAP)-catalysed oxidative synthesis of diaryl sulfone under mild ligand- and base-free conditions

A simple, eco-friendly and efficient method for the synthesis of unsymmetrical diaryl sulfones using heterogeneous copper fluorapatite (CuFAP)-catalysed coupling of aryl sulfonic acid and phenyl boronic acid has been developed with good to excellent yields without use of any ligand, base or co-catalyst. Broad substrate scope and gram scale operations are the important features of this method.