16654-74-3Relevant articles and documents
Co2(CO)8-catalyzed reactions of acetals or lactones with hydrosilanes and carbon monoxide. A new access to the preparation of 1,2-diol derivatives through siloxymethylation
Chatani, Naoto,Fujii, Satoru,Kido, Yoichi,Nakayama, Yasuhide,Kajikawa, Yasuteru,Tokuhisa, Hideo,Fukumoto, Yoshiya,Murai, Shinji
, p. 81 - 90 (2021/02/05)
The Co2(CO)8-catalyzed reaction of acetals with hydrosilanes and CO under mild reaction conditions (an ambient temperature under an ambient CO pressure), leading to the production of vicinal diols is reported. A siloxymethyl group can be introduced via the cleavage of one of two alkoxy groups in the acetal. The effects of the types of hydrosilanes, acetals, solvents, and reaction temperatures on the yield of siloxymethylation products were examined in detail. The reactivity for hydrosilanes is as follows; HSiMe3 > HSiEtMe2 > HSiEt2Me > HSiEt3. Hemiacetal esters are more reactive than dimethyl acetals. The polarity of the solvent used also has a significant effect on both the course of the reaction as well as the reaction rate. The site-selective siloxymethylation can be achieved in the case of cyclic acetals such as tetrahydrofuran (THF) and tetrahydropyrane (THP) derivatives, depending on the nature of the oxygen substituent attached adjacent to the oxygen atom in the ring. When 2-alkoxy THF or THP derivatives are used as substrates, the siloxymethylation takes place with cleavage of the ring C-O bond. In contrast, the reaction of 2-acetoxy THF or THP derivatives results in siloxymethylation with the cleavage of C-OAc bond. The ring-opening siloxymethylation of lactones was also examined.
Counterattack Reagent Bis(trimethylsilyl)acetamide in the Disilylation of Diols
Hwu, Jih Ru,Anderson, Denise A.,Wang, Naelong,Buchner, Meredith M.,Gani, Paul,Tsay, Shwu-Chen
, p. 1667 - 1671 (2007/10/02)
The counterattack method was applied to the disilylation of diols.Treatment of various diols with 0.3 or 1.1 equivalents of potassium hydride and 1.1 equivalents of bis(trimethylsilyl)acetamide in THF gave the corresponding disilyl ethers in good to excellent yields (60-95percent).The diols may contain other functionalities, such as amide, amine, ether, and thioether.The diols used in the disilylation were 2a-14a.The newly developed disilylation proceeded in one flask by a sequential deprotonation-silylation-deprotonation-silylation pathway.This disilylation also represents an example of a "tandem double-counterattack process".Bis(trimethylsilyl)acetamide acted as a counterattack reagent; it provided two Me3Si groups to diols and produced amides as bases.
Fluorophosphoranes as Lewis acids. The conditions of access to hexacoordinated neutral adducts via the intramolecular addition of an electrondonor
Robert, Dominique,Gawad, Hoda Abdel,Riess, Jean G.
, p. 511 - 516 (2007/10/02)
The possibility of obtaining bicyclic neutral hexacoordinated fluorophosphorus adduct of type 2 was investigated for R=F, Me, Ph and X=O, S, NH, NMe, NtBu NPh.Adduct 2g was formed predominantly only in the case where R=F and X=S.In all the othe