1740-97-2Relevant academic research and scientific papers
Some unusual transformations of a highly reactive α-bromocaranone
Samkian, Adrian E.,Sercel, Zachary P.,Virgil, Scott C.,Stoltz, Brian M.
supporting information, (2022/01/04)
The facile synthesis of a highly reactive α-bromocaranone from (+)-carene is reported. This intermediate was found to generate diverse chiral building blocks through radical or carbocation mediated cyclopropyl fragmentation reactions in moderate to excellent yields. Furthermore, the formation of an unexpected carvone derivative prompted several control studies that provided mechanistic insight into an unusual transformation. This study not only demonstrates the synthesis of a variety of chiral building blocks but provides insight into the reactivity of keto-halo-cyclopropanes in general.
IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS
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, (2020/01/08)
Disclosed is a compound represented by formula (I). The half-doted double lines each represent a carbon-carbon single bond or a carbon-carbon double bond. The six-membered ring comprises exactly one endocyclic carbon-carbon double bond or exactly two endocyclic carbon-carbon double bonds. When the six-membered ring comprises exactly two endocyclic carbon-carbon double bonds, the endocyclic carbon-carbon double bonds are either in 1,3-relationship or in 1,4-relationship. R is selected from the group consisting of iso-propyl, iso-butyl, sec-butyl and tert-butyl.
CYCLOHEXENE DERIVATIVES AS PERFUMING INGREDIENTS
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, (2018/10/19)
The present invention concerns a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein n is 0 or 1; R and R', independently from each other, represent a hydrogen atom or a C1-2 linear alkyl group provided that one of said groups represents a hydrogen atom and the other a C1-2 linear alkyl group; each R1, independently from each other, represents a hydrogen atom or a methyl group; and R2 and R3 represent, independently of each other, a C1-3 linear alkyl group; or R2 and R3, when taken together, represent a C4-5 linear, branched alkanediyl or alkenediyl. The use of compound of formula (I) as perfuming ingredients of floral type and the invention's compounds as part of a perfuming composition or of a perfuming consumer product are also part of the present invention.
Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor
Dong, Suwei,Hamel, Ernest,Bai, Ruoli,Covell, David G.,Beutler, John A.,Porco Jr., John A.
supporting information; experimental part, p. 1494 - 1497 (2009/07/25)
A bicycle built for tubulin: The Total synthesis of (+)- chamaecypanone C has been achieved by using a tandem retro-Diels-Alder cascade reaction (see scheme). Initial biological studies demonstrate that (+)- chamaecypanone C is an inhibitor of tubulin assembly and binds at the colchicine site.
Sodium metaperiodate oxidation of isocarvacrol
Kamat, Shrivallabh P.,D'Souza, Asha M.,Paknikar, Shashikumar K.
, p. 395 - 397 (2007/10/03)
Sodium metaperiodate oxidation of isocarvacrol 8, a monoterpene phenol has been found to give hydrothymoquinone 13, a natural product and a ring cleavage product 7-oxo-5-isopropyloct-3-en-2,5-olide 14.
Preparation of diphenolics
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, (2008/06/13)
A process for the production of diphenolic compounds having a divalent bridge. A first disubstituted phenol is reacted with an aldehyde in the presence of a secondary amine and excess alcohol to form an ether intermediate. The ether intermediate is reacted with a phenol having an open ortho or para position to form a diphenolic.
5-Isopropyl-3-methylbenzene-1,2-diol
Carman, Raymond M.,Dongen, Jacobus M. A. M. Van
, p. 2607 - 2610 (2007/10/02)
5-Isopropyl-3-methylbenzene-1,2-diol, obtained by thermal degradation of the diterpenoid 3,10-dihydroxydielmentha-5,11-diene-4,9-dione, has been synthesized.
