1806-23-1

Basic information

• Product Name: 2-Chloro-4'-fluorobenzophenone
• Synonyms: 2-CHLORO-4'-FLUOROBENZOPHENONE;2,4'-CFBP;4'-FLUORO-2-CHLOROBENZOPHENONE;(2-chlorophenyl)(4-fluorophenyl)-methanon;2-Chloro-4'-fluorobenzophenone 99%;2-Chloro-4'-fluorobenzophenone99%;(2-Chlorophenyl)(4-fluorophenyl)methanone;2-Chloro-4'-fluorobe
• CAS NO: 1806-23-1
• Molecular Formula: C₁₃H₈ClFO
• Molecular Weight: 234.65
• EINECS: 217-300-4
• Product Categories: Fluorobenzene Series
• Mol File: 1806-23-1.mol

Chemical Properties

• Melting Point: 60-62°C
• Boiling Point: 337.3 °C at 760 mmHg
• Flash Point: 157.8 °C
• Appearance: /
• Density: 1.277 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-4'-fluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4'-fluorobenzophenone(1806-23-1)
• EPA Substance Registry System: 2-Chloro-4'-fluorobenzophenone(1806-23-1)

Safety Data

• Hazard Codes: Xi
• Statements: 21
• Safety Statements: 28
• Hazardous Substances Data: 1806-23-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless solid

Upstream product

• 462-06-6 fluorobenzene 
• 609-65-4 o-chlorobenzoyl chloride 
• 67-71-0 dimethylsulfone 
• 85-29-0 2,4'-dichlorobenzophenone 
• 352-34-1 4-fluoro-1-iodobenzene 
• 201230-82-2 carbon monoxide 
• 108-90-7 chlorobenzene 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 78318-35-1 2-chloro-4'-(imidazol-1-yl)benzophenone 
• 78318-36-2 (2-chlorophenyl)-<4-(imidazol-1-yl)phenyl>phenylmethyl alcohol 
• 1323396-16-2 C₁₃H₉BrClF 
• 362-55-0 (2-chlorophenyl)(4-fluorophenyl)methanol 

Relevant articles and documents

A Dendralenic C-H Acid

The design and synthesis of a strong, dendralenic C-H acid is described. Crystal structure analyses confirm the proposed structure. Despite the moderate stability of our motif, an application to Bronsted acid catalysis has been explored.

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

A general approach to intermolecular carbonylation of arene C-H bonds to ketones through catalytic aroyl triflate formation

The development of metal-catalysed methods to functionalize inert C-H bonds has become a dominant research theme in the past decade as an approach to efficient synthesis. However, the incorporation of carbon monoxide into such reactions to form valuable ketones has to date proved a challenge, despite its potential as a straightforward and green alternative to Friedel-Crafts reactions. Here we describe a new approach to palladium-catalysed C-H bond functionalization in which carbon monoxide is used to drive the generation of high-energy electrophiles. This offers a method to couple the useful features of metal-catalysed C-H functionalization (stable and available reagents) and electrophilic acylations (broad scope and selectivity), and synthesize ketones simply from aryl iodides, CO and arenes. Notably, the reaction proceeds in an intermolecular fashion, without directing groups and at very low palladium-catalyst loadings. Mechanistic studies show that the reaction proceeds through the catalytic build-up of potent aroyl triflate electrophiles.

Catalytic Friedel-Crafts acylation: Magnetic nanopowder CuFe 2O4 as an efficient and magnetically separable catalyst

Catalytic regioselective Friedel-Crafts acylation of an array of anisoles/arenes with various acid chlorides using 5-20 mol % of magnetic nanopowder CuFe2O4 is reported. Unlike the conventional Friedel-Crafts reactions, which are catalyzed by moisture sensitive homogeneous catalysts/promoters, the nanopowder CuFe2O4 catalyst is moisture insensitive and the product/ketone-catalyst isolation is easily achieved using the magnetic properties of CuFe2O4.

Method for acylation or sulphonylation of an aromatic compound

The present invention relates to a process for the acylation or sulphonylation of an aromatic compound. More particularly, the invention relates to a process for the acylation or sulphonylation of an activated or deactivated aromatic compound. The invention is applied to the preparation of aromatic ketones or sulphones. The process for the acylation or sulphonylation of an aromatic compound which consists in reacting at least one aromatic compound with an acylating or sulphonylating agent, in the presence of a Friedel-Crafts catalyst is characterized in that the acylation or sulphonylation reaction is carried out in liquid phase under microwave irradiation.

Halophenylethylenes

These compounds have the general formula: STR1 wherein R and R1, which may be the same or different, are hydrogen or alkyl, preferably C1 -C4 alkyl, and X, Y and Z are each independently hydrogen, chlorine or fluorine, provided that when R, R1 and Z are hydrogen, X and Y are not both hydrogen or both fluorine, and are prepared by dehydrating an alcohol of the formula: STR2 by, for example, heating the alcohol in the presence of a catalytic amount of a strong acid such as p-toluenesulphonic acid and preferably in the presence of an inert solvent. The compounds are intermediate for the preparation of fungicidal compounds.

Process for producing fluorobenzophenone derivatives

4-Fluorobenzophenone derivatives of 4,4'-difluorobenzophenone are produced by effecting a halogen-fluorine exchanging reaction between the corresponding 4-halogenobenzophenone derivatives or 4,4'-dihalogenobenzophenone and an alkali fluoride. The reaction is carried out by heating in an organic solvent. After distilling off the solvent from the reaction product mixture, the end product is isolated by extracting with a solvent. Alternatively the end product is isolated by distillation.