1806-23-1

Basic information

• Product Name: 2-Chloro-4'-fluorobenzophenone
• Synonyms: 2-CHLORO-4'-FLUOROBENZOPHENONE;2,4'-CFBP;4'-FLUORO-2-CHLOROBENZOPHENONE;(2-chlorophenyl)(4-fluorophenyl)-methanon;2-Chloro-4'-fluorobenzophenone 99%;2-Chloro-4'-fluorobenzophenone99%;(2-Chlorophenyl)(4-fluorophenyl)methanone;2-Chloro-4'-fluorobe
• CAS NO: 1806-23-1
• Molecular Formula: C₁₃H₈ClFO
• Molecular Weight: 234.65
• EINECS: 217-300-4
• Product Categories: Fluorobenzene Series
• Mol File: 1806-23-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 60-62°C
• Boiling Point: 337.3 °C at 760 mmHg
• Flash Point: 157.8 °C
• Appearance: /
• Density: 1.277 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-4'-fluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4'-fluorobenzophenone(1806-23-1)
• EPA Substance Registry System: 2-Chloro-4'-fluorobenzophenone(1806-23-1)

Safety Data

• Hazard Codes: Xi
• Statements: 21
• Safety Statements: 28
• Hazardous Substances Data: 1806-23-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless solid

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 108-90-7 chlorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 201230-82-2 carbon monoxide 
• 462-06-6 fluorobenzene 
• 609-65-4 o-chlorobenzoyl chloride 
• 67-71-0 dimethylsulfone 
• 85-29-0 2,4'-dichlorobenzophenone 

Downstream Products

• 362-55-0 (2-chlorophenyl)(4-fluorophenyl)methanol 
• 1323396-16-2 C₁₃H₉BrClF 
• 78318-36-2 (2-chlorophenyl)-<4-(imidazol-1-yl)phenyl>phenylmethyl alcohol 
• 78318-35-1 2-chloro-4'-(imidazol-1-yl)benzophenone 

Relevant articles and documents

A Dendralenic C-H Acid

The design and synthesis of a strong, dendralenic C-H acid is described. Crystal structure analyses confirm the proposed structure. Despite the moderate stability of our motif, an application to Bronsted acid catalysis has been explored.

A general approach to intermolecular carbonylation of arene C-H bonds to ketones through catalytic aroyl triflate formation

The development of metal-catalysed methods to functionalize inert C-H bonds has become a dominant research theme in the past decade as an approach to efficient synthesis. However, the incorporation of carbon monoxide into such reactions to form valuable ketones has to date proved a challenge, despite its potential as a straightforward and green alternative to Friedel-Crafts reactions. Here we describe a new approach to palladium-catalysed C-H bond functionalization in which carbon monoxide is used to drive the generation of high-energy electrophiles. This offers a method to couple the useful features of metal-catalysed C-H functionalization (stable and available reagents) and electrophilic acylations (broad scope and selectivity), and synthesize ketones simply from aryl iodides, CO and arenes. Notably, the reaction proceeds in an intermolecular fashion, without directing groups and at very low palladium-catalyst loadings. Mechanistic studies show that the reaction proceeds through the catalytic build-up of potent aroyl triflate electrophiles.

Method for acylation or sulphonylation of an aromatic compound

The present invention relates to a process for the acylation or sulphonylation of an aromatic compound. More particularly, the invention relates to a process for the acylation or sulphonylation of an activated or deactivated aromatic compound. The invention is applied to the preparation of aromatic ketones or sulphones. The process for the acylation or sulphonylation of an aromatic compound which consists in reacting at least one aromatic compound with an acylating or sulphonylating agent, in the presence of a Friedel-Crafts catalyst is characterized in that the acylation or sulphonylation reaction is carried out in liquid phase under microwave irradiation.