18165-76-9

Usage

Uses

Used in Chemical Synthesis:
Trimethylsilylmethanethiol is used as a reagent in the synthesis of various chemical compounds. Its unique structure allows it to be a valuable building block in the creation of new molecules with potential applications in different industries.
Used in Laboratory Research:
Trimethylsilylmethanethiol is used as a research tool in laboratories to study its properties and potential applications. It can be employed in experiments to understand its reactivity and interactions with other compounds, which may lead to the development of new chemical processes or products.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, trimethylsilylmethanethiol could potentially be used in the pharmaceutical industry as an intermediate in the synthesis of drug molecules. Its unique structure may contribute to the development of new therapeutic agents with novel properties and applications.
Used in Material Science:
Trimethylsilylmethanethiol may also find applications in material science, where it could be used to modify the properties of materials or create new materials with specific characteristics. Its use in this field would depend on further research and development to explore its potential in this area.

Upstream product

• 2344-80-1 Chloromethyltrimethylsilane 
• 75-77-4 chloro-trimethyl-silane 
• 74-93-1 methylthiol 
• 17356-08-0 thiourea 
• 1310-73-2 sodium hydroxide 
• 18293-51-1 trimethyl(thiocyanatomethyl)silane 

Downstream Products

• 26205-47-0 2-Trimethylsilylmethylthioaethanol 
• 4712-51-0 bis<(trimethylsilyl)methyl>sulfide 
• 119547-77-2 trimethyl<<(2-methylphenyl)methylthio>methyl>silane 
• 166537-02-6 4-methoxy-2-methylbenzyl (trimethylsilyl)methyl sulfide 
• 1352077-16-7 (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(((trimethylsilyl)methyl)thio)butan-2-yl)piperidin-2-one 
• 808139-29-9 2,3-dichloro-N-[3-methoxy-5-[[(trimethylsilyl)methyl]thio]pyrazin-2-yl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-benzenesulfonamide 
• 166537-00-4 4-methoxybenzyl (trimethylsilyl)methyl sulfide 
• 98909-93-4 (4-Chloro-phenyldisulfanylmethyl)-trimethyl-silane 
• 17988-38-4 trimethyl<<(phenyl)methyl>thiomethyl>silane 
• 76380-19-3 1-trimethylsilylmethylthiomethyl-3,3-dimethylcyclohexene 
• 139458-87-0 S-Methyl-S'-trimethylsilylmethyl N-(p-toluenesulfonyl)dithioiminocarbonate 
• 139474-76-3 S,S'-Bis(trimethylsilylmethyl) N-(p-toluenesulfonyl)dithioiminocarbonate 

Relevant academic research and scientific papers

Synthesis and biological activity of Δ-5,6-norcantharimides: importance of the 5,6-bridge

Cantharidin (1) and norcantharidin (2) are potent protein phosphatase 1 and 2A inhibitors that also display high levels of anticancer activity against a broad range of tumor cells lines. Surprisingly, Δ-5,6-ethyl norcantharidin (3, cis-tetrahydrofurano[3,4-c]furan-1,3-dione) displays neither phosphatase inhibition nor anticancer activity. This suggests that the 5,6-ethyl bridge is pivotal to both anti-cancer and protein phosphatase activity. Additionally bioisosteric replacement of the ethereal oxygen has no effect on biological activity nor does modification of the anhydride moiety. Unlike the parent norcantharidin, anhydride ring opening has no effect on either protein phosphatase inhibition or anti-cancer activity. Additionally, this work highlights the discovery of the octyl substituted, cis-5-benzyl-2-hexyltetrahydro-2H,3aH-pyrrolo[3,4-c]pyrrole-1,3-dione, 9p, and the octyl substituted, cis-octyltetrahydro-5H-furo[3,4-c]pyrrole-4,6-dione, 8p, as two new cytotoxic agents which are equipotent (9p) with, and more potent (8p) than norcantharidin. Crown Copyright

Synthesis of butenolides recently isolated from marine microorganisms

The syntheses and 13C NMR analyses of four diastereomeric butenolides, two of which were recently isolated from the marine microorganisms Streptomycete B 5632 and Streptoverticillium luteoverticillatum 11014 are described. The two isolated butenolides were found to be one of the two diastereomers (4S,10R*,11R*)-4,11-dihydroxy-10-methyl-dodec-2-en-1,4-olide (RRS-1 or SSS-1) and one of the two diastereomers (4S,10S*,11R*)-4,11-dihydroxy-10-methyl-dodec-2-en-1,4-olide (SRS-1 or RSS-1). An asymmetric 1,3-dipolar cycloaddition of a thiocarbonyl ylide with a dipolarophile attached to camphorsultam and a ring-opening of an enantiomerically pure vinyloxirane by lithiated dithiane served as key steps for the construction of the three stereogenic centres. Further elaborations including ring-closing metathesis and Mitsunobu inversion furnished the four diastereomeric butenolides.

Method of producing silylalkylthiols

Silylalkylthiols are produced by reacting silylalkylsulfanylsilanes with water. The silylalkylsulfanylsilanes used as starting products can be produced by reacting bil-silylalkylpolysulfanes or bis-silylalkyldisulfanes with alkali metal and chlorosilanes.

Synthesis and Reactions of 3-Mercaptocyclobutanol and Derivatives. Preparation of a 2,4-Dithiabicycloheptane

Reaction of the lithio derivative of 2-tetrahydropyran (4) with epichlorohydrin gave both isomers of 3--3-(trimethylsilyl)-1-(trimethylsiloxy)cyclobutane (5).The latter compound upon treatment wi

GENERATION OF THIOALDEHYDES VIA FLUORIDE INDUCED ELIMINATION OF Α-SILYLDISULFIDES

A mild, efficient and general method for the generation of reactive thioaldehydes from α-silyldisulfides is described.