1848-24-4

Usage

Uses

Used in Pharmaceutical Industry:
Nsc119463 is used as an anti-cancer agent for its potential to inhibit the growth of cancer cells, especially in breast and colon cancers. Its anti-cancer properties make it a promising candidate for further research and development in oncology.
Nsc119463 is also used as an anti-inflammatory agent for its ability to reduce the production of pro-inflammatory molecules. This application can be beneficial in the treatment of various inflammatory conditions and diseases.
Further research is required to explore the full potential of Nsc119463 in different medical applications and to understand its mechanisms of action.

InChI:InChI=1/C14H11NO2/c16-13-14(17,10-6-2-1-3-7-10)11-8-4-5-9-12(11)15-13/h1-9,17H,(H,15,16)/t14-/m1/s1

Upstream product

• 91-56-5 indole-2,3-dione 
• 591-51-5 phenyllithium 
• 2989-63-1 2-phenyl-3H-indol-3-one 
• 477950-02-0 3-amino-3-phenylquinoline-2,4(1H,3H)-dione 
• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 
• 194869-04-0 2-((triisopropylsilyl)oxy)aniline 
• 95-55-6 2-amino-phenol 
• 1334683-33-8 C₂₃H₃₁NO₃Si 
• 1334683-40-7 C₁₄H₁₁NO₃ 
• 948-65-2 2-phenyl-indole 
• 100-59-4 phenylmagnesium chloride 
• 19319-35-8 (E)-2-phenyl-3-(2-nitrophenyl)propenoic acid 

Downstream Products

• 77014-60-9 3-Imidazol-1-yl-3-phenyl-1,3-dihydro-indol-2-one 
• 42773-27-3 3-chloro-3-phenyl-1,3-dihydroindol-2-one 
• 3456-79-9 3-phenyloxindole 
• 900811-77-0 3-phenyl-3-hydroxy-1,3-dihydro-indol-2-one 
• 1463045-73-9 (±)-3-(1H-indol-3-yl)-3-phenylindolin-2-one 
• 1567850-21-8 (R)-tert-butyl 3-phenyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 
• 1588428-23-2 C₁₅H₁₀F₃NOS 
• 1567850-19-4 (S)-tert-butyl 3-phenyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 
• 863779-22-0 3-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-dihydroindol-2-one 
• 1351708-13-8 (S)-3-amino-3-phenylindolin-2-one 

Relevant academic research and scientific papers

Synthetic Studies toward 1,2,3,3a,4,8b-Hexahydropyrrolo[3,2-b]indole Core. Unusual Fragmentation with 1,2-Aryl Shift

Base-assisted transformations of 2-(3-oxoindolin-2-yl)acetonitriles were investigated. Unexpectedly, attempted reactions of substrates possessing nonprotected nitrogen atoms were accompanied by unusual extrusions of 2-arylacetonitriles, followed by a 1,2-aryl shift to afford 3-hydroxyindolin-2-ones. On the other hand, the reactions for N-alkyl derivatives of oxoindolines took the expected route by only providing 1,2,3,3a,4,8b-hexahydropyrrolo[3,2-b]indoles.

Asymmetric organocatalytic α-amination of 2-oxindoles with bis(2,2,2-trichloroethyl)azo-dicarboxylate

An enantioselective electrophilic amination of 3-substituted-2-oxindoles is reported, using bis(2,2,2-trichloroethyl)azo-dicarboxylate and commercially available Cinchona alkaloid organocatalysts. The best results were obtained in the reaction of 3-aryl s

2-Arylindoles: A new entry to transition metal-free synthesis of 2-aminobenzophenones

Various 2-aminobenzophenones were synthesized from readily available 2-arylindoles in DMSO under O2 balloon atmosphere. The synthesis was carried out without the aid of a transition metal catalyst or moisture-sensitive organometallic reagents from 2-arylindoles.

Reduction of 3-aminoquinoline-2,4(1H,3H)-diones and deamination of the reaction products

3-Aminoquinoline-2,4-diones were stereoselectively reduced with NaBH 4 to give cis-3-amino-3,4-dihydro-4-hydroxyquinolin-2(1H)-ones. Using triphosgene (=bis(trichloromethyl) carbonate), these compounds were converted to 3,3a-dihydrooxazolo[4,5-

A facile pathway to enantiomerically enriched 3-hydroxy-2-oxindoles: Asymmetric intramolecular arylation of α-keto amides catalyzed by a palladium-DifluorPhos complex

Less metal wastes: The first catalytic, enantioselective intramolecular aryl-transfer reaction of aryl triflates to ketones has been developed (see scheme; R1=R2=aromatic and aliphatic). This method features overall practicality, inc

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

The Pd-catalysed asymmetric intramolecular α-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used. The Royal Society of Chemistry.