18907-52-3

Basic information

• Product Name: phenyl(4-phenylpiperazin-1-yl)methanone
• Synonyms: methanone, phenyl(4-phenyl-1-piperazinyl)-; Phenyl-(4-phenyl-piperazin-1-yl)-methanone
• CAS NO: 18907-52-3
• Molecular Formula: C₁₇H₁₈N₂O
• Molecular Weight: 266.3376
• Mol File: 18907-52-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 443.5°C at 760 mmHg
• Flash Point: 199.1°C
• Density: 1.159g/cm³
• Vapor Pressure: 4.61E-08mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: phenyl(4-phenylpiperazin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(4-phenylpiperazin-1-yl)methanone(18907-52-3)
• EPA Substance Registry System: phenyl(4-phenylpiperazin-1-yl)methanone(18907-52-3)

Safety Data

• Hazardous Substances Data: 18907-52-3(Hazardous Substances Data)

Usage

General Description

Phenyl(4-phenylpiperazin-1-yl)methanone, also known as 4'-methyl-α-pyrrolidinobutiophenone or 4-MeMABP, is a psychoactive substance that belongs to the cathinone class of drugs. It is a synthetic stimulant that acts on the central nervous system, producing effects similar to those of amphetamines and cocaine. 4-MeMABP is known to induce feelings of euphoria, increased energy, and heightened alertness. It is commonly used recreationally for its stimulating and mood-enhancing effects. However, 4-MeMABP also carries a risk of dependence and adverse health effects, and its use is illegal in many countries.

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Relevant articles and documents

N,O-Benzyl Protection of Structurally Varied Amines and Phenols Using Wells-Dawson Heteropolyacid Catalyst

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Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.