18907-52-3

Usage

Uses

Used in Recreational Drug Use:
Phenyl(4-phenylpiperazin-1-yl)methanone is used as a recreational substance for its stimulating and mood-enhancing effects, providing users with a sense of euphoria, increased energy, and heightened alertness.
However, it is important to note that 4-MeMABP carries a risk of dependence and adverse health effects, and its use is illegal in many countries due to these concerns.

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 98-88-4 benzoyl chloride 
• 62-53-3 aniline 
• 93-89-0 benzoic acid ethyl ester 
• 63412-06-6 N-methyl-N-nitrosobenzamide 
• 88070-48-8 N-methylbenzamide 
• 100-52-7 benzaldehyde 
• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.

Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.

Cross-Dehydrogenating Coupling of Aldehydes with Amines/R-OTBS Ethers by Visible-Light Photoredox Catalysis: Synthesis of Amides, Esters, and Ureas

A straightforward synthesis of amides, ureas, and esters is reported by visible-light cross-dehydrogenating coupling (CDC) of aldehydes (or amine carbaldehydes) and amines/R-OTBS ethers by photoredox catalysis. The reaction is found to be general and high yielding. A plausible mechanistic pathway has been proposed for these transformations and is supported by appropriate controlled experiments.

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

High-load, soluble oligomeric carbodiimide: Synthesis and application in coupling reactions

A facile preparation of a high-load, soluble oligomeric alkyl cyclohexylcarbodiimide (OACC) reagent via ROM polymerization from commercially available starting materials is described. This reagent is exploited as a coupling reagent for esterification, amidation, and dehydration of carboxylic acids (aliphatic and aromatic) with an assortment of alcohols (aliphatic primary, secondary, and benzylic), thiols, phenols, and amines (aliphatic primary, secondary, benzylic, and aromatic/anilines), respectively. Following the coupling event, precipitation with an appropriate solvent (Et2O, MeOH, or EtOAc), followed by filtration through a SPE provides the products in good to excellent yield and purity.

Photoinitiated carbonylation with [11C]carbon monoxide using amines and alkyl iodides

Photoinitiated radical carbonylation with [11C]carbon monoxide at low concentration was employed in syntheses of carbonyl-11C- labeled amides using alkyl iodides and amines as precursors. Eleven 11C-amides were synthesized