1898-74-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4-diphenyl-1,3,5-triazine is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical properties.
Used in Agrochemical Industry:
2,4-diphenyl-1,3,5-triazine is used as a component in the development of agrochemicals, contributing to its effectiveness in agricultural applications.
Used in Dye Industry:
2,4-diphenyl-1,3,5-triazine is used as a key intermediate in the production of dyes, enhancing their color and performance characteristics.
Used in UV-absorbing Materials:
2,4-diphenyl-1,3,5-triazine is used as a light stabilizer in the preparation of UV-absorbing materials, protecting plastics, polymers, and coatings from UV-induced degradation.
Used in Cancer Research:
2,4-diphenyl-1,3,5-triazine has shown potential as an anti-cancer agent in laboratory research, indicating its possible use in the development of cancer treatments.
Used in Inflammation Research:
2,4-diphenyl-1,3,5-triazine has demonstrated anti-inflammatory properties in laboratory research, suggesting its potential use in the development of anti-inflammatory drugs.

Upstream product

• 290-87-9 1,3,5-Triazine 
• 618-39-3 benzamidin 
• 1670-14-0 benzamidine monohydrochloride 
• 6313-33-3 formamidine hydrochloride 
• 109-94-4 formic acid ethyl ester 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1558-67-4 formic anhydride 
• 79-22-1 methyl chloroformate 
• 74466-89-0 5-Phenyl-1,2,4-thiadiazole 
• 67-56-1 methanol 
• 1634-04-4 tert-butyl methyl ether 
• 51721-68-7 4-methoxybenzamidine hydrochloride 
• 18637-00-8 2-ethoxy-benzamidine hydrochloride 
• 57297-29-7 cyclopropylcarboxamidine hydrochloride 

Downstream Products

• 68265-99-6 4,6-diphenyl-1,3,5-triazine-2-carbonitrile 
• 5418-07-5 4,6-diphenyl-[1,3,5]triazin-2-ylamine 
• 113696-91-6 α-phenyl-4,6-diphenyl-s-triazine-2-acetonitrile 
• 113696-92-7 Cyano-(4,6-diphenyl-[1,3,5]triazin-2-yl)-acetic acid ethyl ester 
• 113696-93-8 2-phenacyl-4,6-diphenyl-s-triazine 
• 72107-20-1 2,4-diphenyl-6-(trifluoromethyl)-1,3,5-triazine 

Relevant academic research and scientific papers

Expanding the hole delocalization range in excited molecules for stable organic light-emitting diodes employing thermally activated delayed fluorescence

Metal-free, thermally activated delayed fluorescent (TADF) emitters have emerged as a promising new generation of organic light-emitting diode (OLED) materials. Donor-acceptor (D-A) structures are widely used in TADF molecular design to ensure a small energy splitting between the singlet and triplet excitons. Here, a series of efficient bluish-green TADF emitters are constructed using one or two phenyltriazine acceptors and one tercarbazole, bicarbazole or indolo[2,3-b]carbazole donor through an ortho-linkage. The impact of the D/A ratio on the photoluminescence and electroluminescence stability of these emitters in doped films is thoroughly investigated. According to the two-exciton dynamics and the degradation products, device degradation is deduced to be a result of electrophilic substitution between two charge-transfer excitons. Within a limited molecular weight range, increasing the number of acceptor moieties leads to a decrease in the hole delocalization range in the excited state, which facilitates the substitution reaction. Based on an optimized device structure, the device containing an emitter with bulk a tercarbazole donor achieves a long half-life of 1512 hours with an initial luminescence of 1000 cd m-2. Our findings reveal a possible mechanism for exciton-exciton and exciton-polaron annihilation-induced device degradation and provide new approaches for achieving stable OLEDs employing TADF.

Synthesis of 1,2-dihydro-1,3,5-triazine derivativesviaCu(ii)-catalyzed C(sp3)-H activation ofN,N-dimethylethanolamine with amidines

1,2-Dihydro-1,3,5-triazines and symmetrical 1,3,5-triazines were obtained in up to 81% yields from amidines andN,N-dimethylethanolamine catalyzed by CuCl2. The reaction involves three C-N bond formations during the oxidative annulation process

A multi-substituted 1, 3, 5 - triazine (by machine translation)

The present invention discloses a multi-substituted 1, 3, 5 - triazine, in particular to in order to replace the carboxamidine hydrochloride as a reaction substrate, two fluorine chlorine sodium acetate as a carbon synthons, in the equivalent function of

Transition metal-free C-F/C-Cl/C-C cleavage of ClCF2COONa for the synthesis of heterocycles

A transition metal-free and external oxidant-free annulation of substrates having two nitrogen-nucleophilic sites with ClCF2COONa was demonstrated, affording a series of 1,3,5-triazines and quinazolinones in up to 96% yields. Notably, ClCF

Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source

An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The desired symmetric and unsymmetric 2,4-disubstituted-1,3,5-triazines were obtained in decent yields via multiple C-N bond formation, in which ethyl bromodifluoroacetate is harnessed as a unique C1 synthon via quadruple cleavage. This reaction is transition metal-free, oxidant-free and simple in operation, and only lowly toxic inorganic wastes are generated.

New Strategy for the Synthesis of Heterocycles via Copper-Catalyzed Oxidative Decarboxylative Amination of Glyoxylic Acid

A copper-catalyzed oxidative decarboxylative amination of glyoxylic acid with substrates having two nitrogen-nucleophilic sites was first demonstrated. Using this novel approach, 1,3,5-triazines, quinazolinones and quinazolines were obtained in up to 93 % yields. Notably, glyoxylic acid was employed as the C1 synthon for heterocycles. This strategy enriches the application of glyoxylic acid for the synthesis of valuable heterocycles.

Dichloromethane as C1 Building Block: Synthesis of 2,4-Disubstitued 1,3,5-Triazines via Copper-Catalyzed Aerobic C?H/C?Cl Cleavage

A copper-catalyzed aerobic oxidative annulation of amidines with dichloromethane was first demonstrated. Using this novel approach, 16 examples of symmetrical 2,4-disubstitued 1,3,5-triazines and 7 examples of unsymmetrical ones were obtained with up to 82% yields. Moreover, a D-labeling experiment proved that dichloromethane was employed as the C1 building block and solvent. A primary kinetic isotope effect revealed that the C?H cleavage of dichloromethane might be a rate-determining step. This protocol provides a novel strategy for the synthesis of heterocycles. (Figure presented.).

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

An I2-mediated aerobic oxidative annulation of amidines with tertiary amines: Via C-H amination/C-N cleavage for the synthesis of 2,4-disubstituted 1,3,5-triazines

An iodine-mediated formal oxidative cycloaddition of amidines with tertiary amines was first demonstrated in air. Both symmetrical and unsymmetrical 2,4-disubstituted 1,3,5-triazines were obtained in up to 85% yields. It is noted that a tertiary amine was employed as a one carbon synthon of 1,3,5-triazines and two C-N bonds were formed in one pot. Control experiments revealed that the reaction underwent a radical pathway promoted by I+. The method is transition-metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates.