19483-24-0

Basic information

• Product Name: cis-β-Ethoxyacrylsaeure
• CAS NO: 19483-24-0
• Molecular Weight: 116.117
• Mol File: 19483-24-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: cis-β-Ethoxyacrylsaeure(CAS DataBase Reference)
• NIST Chemistry Reference: cis-β-Ethoxyacrylsaeure(19483-24-0)
• EPA Substance Registry System: cis-β-Ethoxyacrylsaeure(19483-24-0)

Safety Data

• Hazardous Substances Data: 19483-24-0(Hazardous Substances Data)

Upstream product

• 5941-55-9 ethyl 3-ethoxyacrylate 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 59938-07-7 (3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one 
• 16339-88-1 (E)-1-bromo-2-ethoxyethene 
• 124-38-9 carbon dioxide 
• 64-17-5 ethanol 
• 54299-82-0 C₉H₁₇NO₂ 
• 6191-99-7 (2E)-3-ethoxyprop-2-enoyl chloride 

Downstream Products

• 6192-01-4 (E)-3-ethoxyprop-2-enoic acid 
• 1621424-10-9 benzyl (E)-3-ethoxyacrylate 
• 6191-99-7 3-ethoxyacryloyl chloride 
• 115983-78-3 (E)-3-ethoxypropenoyl isocyanate 
• 928627-14-9 trans-N-(3-bromo-2-methoxyphenyl)-3-ethoxy-2-propenamide 
• 923973-02-8 (E)-N-(1-(2,6-dichlorophenyl)-4-methyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)-3-ethoxyacrylamide 
• 6191-99-7 (2E)-3-ethoxyprop-2-enoyl chloride 
• 773138-32-2 2-hydroxy-benzene-1,3,5-tricarboxylic acid triethyl ester 

Relevant articles and documents

Haloacetylated Enol Ethers. 8 [12]. Reaction of β-Alkoxyvinyl Trihalomethyl Ketones with Guanidine Hydrochloride. Synthesis of 4-Trihalomethyl-2-Aminopyrimidines

In this work the results of the reaction of β-alkoxyvinyl trihalomethyl ketones 1, 2a-e, with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried out, 4-trihalomethyl-2-amino pyrimidines, β-alkoxyvinyl carboxylic acids, or β-acetal carboxylic esters were obtained.

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

The present disclosure is directed to compounds of formula I and methods of their use and preparation, as well as compositions comprising compounds of formula I.

Electroorganic Synthesis, 56. Synthesis of Advanced Prostaglandin Precursors by Kolbe Electrolysis, I. - Preparation of (1'R,4'S,3R/S)-3-(cis-4-Acetoxycyclopent-2-enyloxy)-3-ethoxypropionic Acid

The key intermediate of a novel synthesis of prostaglandin precursors, (1'R,4'S,3R/S)-3-(cis-4-acetoxycyclopent-2-enyloxy)-3-ethoxypropionic acid (3), is prepared by two different synthetic sequences: In a first strategy transacetalization of ethyl 3,3-diethoxypropionate (6) with (1R,4S)-4-acetoxy-1-hydroxy-2-cyclopentene (7) leads to the formation of the mixed acetal 8.By subsequent hydrolysis and acylation 8 could be converted into acid 3 in six steps in 6percent overall yield.However, the generation of acid 3 by bromoalkoxidation of 3-ethoxyacrylates 13d, e and subsequent electrochemical reduction proved to be more efficient.In this reduction it is possible to debrominate the α-bromo esters 14d, e and to remove the 2-haloethyl ester group in one step.Using this reaction sequence, we could synthesize acid 3 in five steps in 38percent overall yield. - Key Words: Kolbe electrolysis / Radical cyclization / Electrochemical dehalogenation / Prostaglandins