1953-56-6

Usage

Uses

Used in Organic Synthesis:
(E)-2-Butene-1,4-diol di(methanesulfonate) is used as a reagent for its ability to facilitate various organic reactions, particularly those involving the protection and deprotection of hydroxyl groups. (E)-2-Butene-1,4-diol di(methanesulfonate)'s leaving group property aids in the formation of new chemical bonds and the synthesis of complex molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (E)-2-Butene-1,4-diol di(methanesulfonate) is used as a building block for the preparation of bioactive molecules. Its role in creating the structural framework of potential drugs makes it a valuable asset in drug discovery and development.
Used in Material Science:
(E)-2-Butene-1,4-diol di(methanesulfonate) is also utilized in material science for the synthesis of novel materials. Its unique chemical structure allows for the creation of materials with specific properties that can be tailored for various applications.
Safety and Handling:
(E)-2-Butene-1,4-diol di(methanesulfonate) should be stored in a cool, dry place, away from sources of heat and flame to ensure its stability. As with all chemical compounds, it is crucial to follow proper safety protocols when handling and using this substance to prevent accidents and ensure the well-being of those involved in its use.

InChI:InChI=1/C6H12O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-4H,5-6H2,1-2H3/b4-3+

Upstream product

• 6117-80-2 1,4-butenediol 
• 124-63-0 methanesulfonyl chloride 
• 821-11-4 trans-butene-1,4-diol 

Downstream Products

• 1476-11-5 Z-1,4-dichlorobutene 
• 103204-12-2 1-phenyl-2,5-dihydro-1H-pyrrole 
• 6913-92-4 1-benzyl-2,5-dihydro-1H-pyrrole 
• 163776-49-6 methyl 2-(3,4-dihydro)pyrrolidinophenylacetate 
• 199532-88-2 ethyl 1-aminocyclopent-3-ene-1-carboxylate 
• 213316-32-6 rac-(1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 200122-28-7 (1R,2S,5R)-menthyl 2-(3,4-dihydro)pyrrolidinophenylacetate 
• 464174-43-4 1-(3-bromophenyl)-2,5-dihydropyrrole 
• 199532-83-7 ethyl 1-((4-bromobenzylidene)amino)cyclopent-3-ene-1-carboxylate 
• 127839-96-7 1-(2-Chloro-6-methyl-phenyl)-2,5-dihydro-1H-pyrrole 
• 6845-82-5 N-(β-Phenylethyl)-Δ³-pyrrolin 
• 68109-75-1 1-cyclohexyl-2,5-dihydro-1H-pyrrole 
• 6892-53-1 (Z)-1,4-bis(4-nitrophenoxy)but-2-ene 
• 6728-07-0 1,4-Bis-<4-nitro-phenoxy>-but-2t-en 

Relevant academic research and scientific papers

Formal [5+1] annulation reactions of dielectrophilic peroxides: Facile access to functionalized dihydropyrans

A general [5+1] annulation reaction, which utilized 4-bromo- or 4-mesyloxy-but-2-enyl peroxides as unique five-atom bielectrophilic synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with C1 nucleophiles, has been developed for the facile synthesis of 2,2-disubstituted dihydropyrans in high yields under mild basic conditions. The dihydropyrans, which are readily prepared on a gram scale by this new method, can be flexibly transformed into the biologically important tetrahydropyrans and pyranones in 1-2 steps.

METHOD FOR PRODUCING POLYGUANIDINES

A method for preparing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according to the following reaction scheme is provided: wherein X, R1, Gua, Y and Z are as defined in the specification. In the disclosed method, at least one benzyl or allyl derivative BA is subjected to a polycondensation reaction with excessive guanidine, aminoguanidine or diaminoguanidine G upon elimination of HX.

CHIRAL CONTROL

The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.

METHODS FOR THE SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS

Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H- phosphonates in a stereospecific fashion.

3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.

N-ARYL-SUBSTITUTED CYCLIC AMINE DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT

The present invention provides an excellent squalene synthase inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 represents an optionally substituted vinyl group or an aromatic ring which may be substituted; ???n is an integer of 0 to 2; ???X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen a tom, sulfuratomoroxygenatom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring; ???CyA represents a 5- to 14 membered non-aromatic cyclic amino groupornon-aromatic cyclic amidogroupwhichmaybe substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom; ???W represents a chain expressed by(1) optionally substituted -CH2-CH2-,(2) optionally substituted -CH=CH-,(3) -C≡C-,(4) an optionally substituted phenylene group,(5) a single bond,(6) -NH-CO-,(7) -CO-NH-,(8) -NH-CH2-,(9) -CH2-NH-,(10) -CH2-CO-,(11) -CO-CH2-,(12) -O-(CH2)m-,(13) -(CH2)m-O- (where m represents an integer of 0 to 5),(14) -O-CH2-CR2=,(15) -O-CH2-CHR2- (where R2 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom),(16) -NH-S(O)1-,(17) -S(O)1-NH-,(18) CH2-S(O)1-, or(19) -S(O)2-CH2- (where 1 represents 0, 1, or 2); and ???A represents a group having any of the following structural formulae: (wherein R3 and R4 represent independently a hydrogen atom or an optionally substituted C1-6 alkyl group, or combine through a carbon chain optionally containing a heteroatom to form a ring; ???R5 and R6 represent independently a hydrogen atom or an optionally substituted C1-6 alkyl group, or combine through a carbon chain optionally containing a heteroatom to form a ring; ???R7 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, a hydroxyl group, an alkoxy group, a halogen atom or an optionally substituted amino group; ???R8 represents a hydrogen atom, a hydroxyl group, an alkoxy group, a halogen atom or an optionally substituted amino group; ???B1 represents an optionally substituted carbon atom, or an optionallysubstitutednitrogenatom, oxygen atom or sulfur atom; ???B2 represents an optionally substituted carbon atom or nitrogen atom; ???a and b represent an integer of 0 to 4, provided that a+b is an integer of 0 to 4; ???c represents 0 or 1; and----- represents a single bond or a double bond, provided that when c is 1 in which A is a quinuclidine having R8 represented by the case where R8 is a hydrogen atom or a hydroxyl group; Arl is an aromatic heterocycle; and W is one of (1) to (3), (6) to (11) and (16) to (19) are excluded).

A Facile Synthesis of 3-Pyrrolines

N-Substituted 3-pyrrolines were conveniently synthesized in high yield by the treatment of primary amines with cis-2-butene-1,4-diol dimesylate, which was generated from cis-1,4-butenediol.