202120-10-3Relevant articles and documents
Asymmetric Synthesis of N-Substituted γ-Amino Esters and γ-Lactams Containing α,γ-Stereogenic Centers via a Stereoselective Enzymatic Cascade
Li, Ming,Cui, Yunfeng,Xu, Zefei,Chen, Xi,Feng, Jinhui,Wang, Min,Yao, Peiyuan,Wu, Qiaqing,Zhu, Dunming
supporting information, p. 372 - 379 (2021/10/25)
γ-Amino esters and γ-lactams containing α,γ-stereogenic centers are widely used as chiral intermediates in various bioactive compounds, while their efficient synthesis remains a challenge. Herein, an enzymatic cascade reaction involving an ene reductase (
Pyrimidopyrazole compound, preparation method and application thereof
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Paragraph 0285; 0288; 0289, (2020/07/21)
The invention discloses a pyrimidopyrazole compound, a preparation method and application thereof. The invention provides a pyrimidopyrazole compound shown as formula I or pharmaceutically acceptablesalts thereof. The compound has a relatively good inhibition effect on CDK7.
INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS
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Page/Page column 101, (2012/07/13)
The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
