20810-06-4

Basic information

• Product Name: N-isobutylbutylamine
• Synonyms: N-isobutylbutylamine;N-Butyl-2-methylpropylamine
• CAS NO: 20810-06-4
• Molecular Formula: C₈H₁₉N
• Molecular Weight: 129.24316
• EINECS: 244-051-9
• Mol File: 20810-06-4.mol

Chemical Properties

• Boiling Point: 153.4°Cat760mmHg
• Flash Point: 31.8°C
• Appearance: /
• Density: 0.761g/cm³
• Vapor Pressure: 3.34mmHg at 25°C
• Refractive Index: 1.416
• CAS DataBase Reference: N-isobutylbutylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-isobutylbutylamine(20810-06-4)
• EPA Substance Registry System: N-isobutylbutylamine(20810-06-4)

Safety Data

• Hazardous Substances Data: 20810-06-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H19N/c1-4-5-6-9-7-8(2)3/h8-9H,4-7H2,1-3H3

Upstream product

• 855381-73-6 butyl-isobutyl-carbamonitrile 
• 109-73-9 N-butylamine 
• 78-84-2 isobutyraldehyde 
• 109-65-9 1-bromo-butane 
• 78-81-9 isobutylamine 
• 6898-75-5 N-isobutylidenebutylamine 
• 7664-93-9 sulfuric acid 
• 500585-07-9 1-butyl-2,2-dimethyl-aziridine 
• 6282-85-5 N-Butyl-2-methylpropanamide 
• 109-74-0 propyl cyanide 
• 78-83-1 2-methyl-propan-1-ol 

Downstream Products

• 53516-45-3 Cyclohexen-1-yl-n-butylisobutylamin 

Relevant articles and documents

Selective one-pot synthesis of asymmetric secondary amines via N-alkylation of nitriles with alcohols

The synthesis of asymmetric secondary amines (ASA) is commonly achieved by N-alkylation of primary amines with alcohols. Here, we investigated the ASA synthesis via the direct amination of alcohols with nitriles, which avoids the synthesis, separation and purification of the primary amines in a first step. Specifically, the ASA synthesis via N-alkylation of butyronitrile (BN) with primary (n-propanol, iso-butanol and n-octanol) and secondary (2‐propanol, 2‐butanol and 2‐octanol) alcohols was studied on SiO2-supported Co, Ni and Ru catalysts. Competitive BN hydrogenation‐condensation reactions formed dibutylamine (the symmetric secondary amine) and tertiary amines as main secondary products. On Co/SiO2, the ASA selectivities for BN/primary alcohol reactions were between 49 and 58% at complete BN conversion, forming dibutylamine and tertiary amines as byproducts. For BN/secondary alcohol reactions, Co/SiO2 formed selectively (ASA + dibutylamine) mixtures containing 78–85% of ASA, thereby showing that the alcohol amination with nitriles is an attractive alternative route for the synthesis of valuable asymmetric secondary amines.

Catalytic hydrogenation of amides to amines under mild conditions

Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd-Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines. Copyright

Synthesis and C-alkylation of hindered aldehyde enamines

A new reactivity mode of hindered lithium amides with terminal epoxides is described whereby aldehyde enamines are produced via a previously unrecognized reaction pathway. Some of these aldehyde enamines display unprecedented C-alkylation reactivity toward unactivated primary and secondary alkyl halides. For comparison, the reactivity of aldehyde enamines synthesized via a traditional condensation method was examined. C-rather than N-alkylation was the dominant reaction pathway found with a range of electrophiles, making this route to α-alkylated aldehydes more synthetically useful than previously reported.