21203-79-2Relevant academic research and scientific papers
Au(I)-catalyzed domino intramolecular cyclization for the synthesis of 2,4-disubstituted pyrimidines
Zhan, Haiying,Chen, Longbin,Tan, Jingwen,Cao, Hua
, p. 109 - 112 (2016)
An efficient Au-catalyzed domino intramolecular cyclization reaction has been developed for the construction of pyrimidine derivatives from ynals and amidines at room temperature for 3 h. This transformation provides a new method for the formation of C-C
A novel and efficient lewis acid catalysed preparation of pyrimidines: Microwave-promoted reaction of urea and β-formyl enamides
Barthakur, Madan G.,Borthakur, Moyurima,Devi, Prarthana,Saikia, Chandan J.,Saikia, Anil,Bora, Utpal,Chetia, Apurba,Boruah, Romesh C.
, p. 223 - 226 (2007)
A novel and efficient synthesis of pyrimidine from β-formyl enamide is described. The key step involves samarium chloride catalysed cyclisation of β-formyl enamides using urea as source of ammonia under microwave irradiation. Georg Thieme Verlag Stuttgart
Heterogeneous gold(I)-catalyzed cyclization between ynals and amidines: An efficient and practical synthesis of 2,4-disubstituted pyrimidines
Jiang, Minhua,Nie, Quan,Cai, Mingzhong
, p. 2488 - 2500 (2019/07/12)
A novel and highly efficient heterogeneous gold(I)-catalyzed cyclization between ynals and amidines has been developed that proceeds smoothly under mild conditions and provides a general and practical method for the synthesis of a wide variety of 2,4-disu
Pyrimidine as an Aryl C-H Activating Group
Gupta, Sahaj,Melanson, Jennifer A.,Vaillancourt, Louis,Nugent, William A.,Tanoury, Gerald J.,Schatte, Gabriele,Snieckus, Victor
supporting information, p. 3745 - 3748 (2018/07/22)
The Pd-catalyzed regioselective C-H activation/arylation, /iodination, and/acetoxylation reactions of 4-arylpyrimidines using aryl iodides, N-iodosuccinimide, and (diacetoxyiodo)benzene respectively as coupling partners are described. Suzuki-Miyaura coupl
Synthesis of 4-aryl and unsymmetrical 4,6-diarylpyrimidines by the Suzuki-Miyaura cross-coupling reaction
Gupta, Sahaj,Melanson, Jennifer A.,Selim Hossain,Vaillancourt, Louis,Tanoury, Gerald J.,Nugent, William A.,Snieckus, Victor
, p. 1549 - 1569 (2018/10/04)
A two-step procedure for the synthesis of 4-arylpyrimidines from inexpensive 4,6-dichloropyrimidine via a Suzuki-Miyaura/hydrodechlorination reaction sequence is described. The reaction resulted in the predominant formation of mono-arylated product. The c
Cu-Catalyzed [3 + 3] Annulation for the Synthesis of Pyrimidines via β-C(sp3)-H Functionalization of Saturated Ketones
Zhan, Jun-Long,Wu, Meng-Wei,Chen, Fei,Han, Bing
, p. 11994 - 12000 (2016/12/09)
A novel, efficient, and facile approach for the synthesis of structurally important pyrimidines has been successfully developed by Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones. This method provides a new protocol for the synthesis of pyrimidines by a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization via direct β-C(sp3)-H functionalization of saturated ketones followed by annulation with amidines.
Transition Metal Free Intermolecular Direct Oxidative C-N Bond Formation to Polysubstituted Pyrimidines Using Molecular Oxygen as the Sole Oxidant
Guo, Wei,Li, Chunsheng,Liao, Jianhua,Ji, Fanghua,Liu, Dongqing,Wu, Wanqing,Jiang, Huanfeng
, p. 5538 - 5546 (2016/07/13)
Various polysubstituted pyrimidines are smoothly formed via a base-promoted intermolecular oxidation C-N bond formation of allylic C(sp3)-H and vinylic C(sp2)-H of allyllic compounds with amidines using O2 as the sole oxid
Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants
Guo, Wei
, p. 47 - 50 (2016/01/25)
A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthes
Catalytic asymmetric hydrogenation of pyrimidines
Kuwano, Ryoichi,Hashiguchi, Yuta,Ikeda, Ryuhei,Ishizuka, Kentaro
supporting information, p. 2393 - 2396 (2015/03/04)
The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
Catalytic arylation of a C-H bond in pyridine and related six-membered N-heteroarenes using organozinc reagents
Hyodo, Isao,Tobisu, Mamoru,Chatani, Naoto
supporting information; experimental part, p. 1357 - 1365 (2012/08/08)
Despite significant advances in the catalytic direct arylation of heteroarenes, the application of this reaction to pyridines has been met with limited success. An oxidative nucleophilic arylation strategy has been developed to overcome this problem. Pyridine, pyrazine, quinolone, and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using the developed nickel-catalyzed reaction. This protocol serves as a complementary method to catalytic direct arylation reactions. Less is more: Pyridine, pyrazine, quinoline and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using organozinc reagents through nickel catalysis. This protocol serves as a complementary method to catalytic direct arylation reactions. Copyright
