22316-59-2Relevant academic research and scientific papers
Chemical transformations of reaction products of 2-methyl-3-(4-tolyl)-4(3H) -quinazolone with benzil and its 4,4′-derivatives
Ponomarev,Razorenov,Perekalin,Petrovskii,Starikova
, p. 154 - 159 (2007)
The reaction of 2-methyl-3-(4-tolyl)-4(3H)-quinazolone with benzil produces 2-[(Z)-3-oxo-2,3-diphenylprop-1-enyl]-3-(4-tolyl)-4(3H)-quinazolone, which is readily transformed into 2-(3,3-diphenylsuccinimido)-N-(4-tolyl)benzamide on dissolution in organic water-containing solvents. The rearrangement mechanism was suggested and investigated by the quantum chemical PM3 method. Springer Science+Business Media, Inc. 2007.
Catalytic Enantioselective Synthesis of N-C Axially Chiral Mebroqualone and Its Derivatives through Reductive Asymmetric Desymmetrization
Hirai, Motohiro,Terada, Shumpei,Yoshida, Hiroaki,Ebine, Kenki,Hirata, Tomoaki,Kitagawa, Osamu
, p. 5700 - 5703 (2016)
In the presence of (R)-DTBM-SEGPHOS-Pd(OAc)2 catalyst, treatment of various 3-(2,6-dibromophenyl)quinazolin-4-ones with NaBH4 gave optically active N-C axially chiral quinazolinone (mebroqualone) derivatives through reductive asymmet
Development of novel Schiff base fluorophores for selective detection of Cu2+ ions in seawater using test strips
El-Sakka, Sahar S.,El-Shalakany, E.,Kamel, Rasha M.,Soliman, M. H. A.
, (2022/01/26)
A novel Schiff bases of 2-((2-aminophenylimino)methyl)-3-phenyl-4(3H)-quinazolinone (3a), 2-((2-aminophenylimino)methyl)-3-(4-tolyl)-4(3H)-quinazolinone (3b), and 2-((2-aminophenylimino)methyl)-3-(4-anisyl)-4(3H)-quinazolinone (3c) were synthesized and ch
A novel superparamagnetic powerful guanidine-functionalized γ-Fe2O3based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media
Foroughifar, Naser,Khajeh-Amiri, Alireza,Norouzi, Fateme Haji,Pasdar, Hoda
, p. 29948 - 29959 (2021/10/20)
The novel organic-inorganic nanohybrid superparamagnetic (γ-Fe2O3@CPTMS-guanidine@SO3H) nanocatalyst modified with sulfonic acid represents an efficient and green catalyst for the one-pot synthesis of quinazolin-4(3H)-one derivativesviathree-component condensation reaction between anthranilic acid, acetic anhydride and different amines under microwave irradiation and solvent-free conditions (4a-q). XRD, FT-IR, FE-SEM, TGA, VSM and EDX were used to characterize this new magnetic organocatalyst. Outstanding performance, short response time (15-30 min), simple operation, easy work-up procedure, and avoidance of toxic catalysts can be regarded as its significant advantages. Moreover, it can be easily separated from the reaction solution through magnetic decantation using an external magnet, and recycled at least six times without notable reduction in its activity.
α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and other N-heterocyclesviadecarboxylative oxidative annulation reaction
Jung, Chanhyun,Jung, Jae-Kyung,Lee, Heesoon,Lee, Kiho,Lee, Seohu,Park, Yunjeong,Sim, Jaeuk,Viji, Mayavan,Vishwanath, Manjunatha
, p. 37202 - 37208 (2020/10/28)
A metal-free and efficient procedure for the synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and indolo[1,2-a]quinoxaline has been developed. The key features of our method include thein situgeneration of aldehyde from α-hydroxy acid in the presence of TBHP (tert-butyl hydrogen peroxide), and further condensation with various amines, followed by intramolecular cyclization and subsequent oxidation to afford the corresponding quinoxalines, quinazolinones derivatives in moderate to high yields.
Preparation of 4(3H)-quinazolinones from aryldiazonium salt, nitriles and 2-aminobenzoate via a cascade annulation
Ramanathan, Mani,Hsu, Ming-Tsung,Liu, Shiuh-Tzung
, p. 791 - 796 (2019/01/08)
One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone.
Palladium-catalyzed four-component carbonylative synthesis of 2,3-disubstituted quinazolin-4(3H)-ones: Convenient methaqualone preparation
Peng, Jin-Bao,Geng, Hui-Qing,Wang, Wei,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng
, p. 10 - 13 (2018/07/03)
A palladium-catalyzed four-component carbonylative cyclization reaction for the synthesis of 2,3-disubstituted quinazolin-4(3H)-ones has been developed. A range of different 2,3-disubstituted quinazolin-4(3H)-one derivatives were prepared in moderate to good yields employing simple and readily accessible 2-iodoanilines, nitro compounds and acid anhydrides as the synthetic precursors. Mo(CO)6 acted both as a solid CO source and a reductant. Notably, methaqualone as a sedative and hypnotic medication can be prepared easily in 68% yield (4b) under our conditions as well.
A quinazoline compound and its synthesis method
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Paragraph 0080-0083, (2017/11/16)
The invention discloses a synthetic method of a quinazolinone compound. The method can be used for preparing the quinazolinone compound by carrying out reaction at a proper temperature and time by taking a 2-aminobenzamide derivative and a 1, 3-diketone compound as raw materials, taking chiral Bronsted acid or Lewis acid as a catalyst and water and biodegradable ethyl lactate and polyethylene glycol as a mixed solvent. The synthetic method of the quinazolinone compound provided by the invention is mild in reaction condition, low in cost, environment-friendly, high in yield and suitable for industrial production.
FeCl3-catalyzed tandem condensation/intramolecular nucleophilic addition/C-C bond cleavage: A concise synthesis of 2-substitued quinazolinones from 2-aminobenzamides and 1,3-diketones in aqueous media
Shen, Guanshuo,Zhou, Haifeng,Sui, Yuebo,Liu, Qixing,Zou, Kun
supporting information, p. 587 - 590 (2016/01/20)
A concise approach for the synthesis of 2-substituted quinazolinones using an iron-catalyzed tandem reaction of 2-aminobenzamides with acyclic or cyclic 1,3-diketones via condensation, intramolecular nucleophilic addition, C-C bond cleavage in an aqueous solution of poly(ethylene glycol) under oxidant-free conditions has been developed.
Synthesis, biological evaluation and structure-activity relationship of 2-styrylquinazolones as anti-tubercular agents
Jadhavar, Pradeep S.,Dhameliya, Tejas M.,Vaja, Maulikkumar D.,Kumar, Dinesh,Sridevi, Jonnalagadda Padma,Yogeeswari, Perumal,Sriram, Dharmarajan,Chakraborti, Asit K.
supporting information, p. 2663 - 2669 (2016/05/09)
2-Styrylquinazolones are reported as a novel class of potent anti-mycobacterial agents. Forty-six target compounds have been synthesized using one pot reaction involving isatoic anhydride, amine, and triethyl orthoacetate followed by aldehyde to construct
